NSF/FDA Scholar In Residence: Vessel Rupture Thresholds for Microbubble-Assisted High-Intensity Therapeutic Ultrasound

NSF/FDA 常驻学者：微泡辅助高强度超声治疗的血管破裂阈值

• 批准号: 1641221
• 负责人: Damir Khismatullin
• 金额: $ 5.05万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2017-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1641221&HistoricalAwards=false
• 关键词: NSF; FDA; Scholar; Residence; Vessel

ABSTRACTPI: Khismatullin, DamirProposal Number: 1641221 High-intensity focused ultrasound has recently gained recognition as a noninvasive ionizing radiation-free therapeutic method. It is being explored for treatment of cancer, neurological diseases, and circulatory system-related cardiovascular diseases. To avoid permanent damage and to identify vessel rupture thresholds for HITU devices experiments and modeling of bubble dynamics in blood vessels will be performed. This project will lead to a computational tool and a new formula for HITU safety threshold assessment that will give patients in the U.S. faster access to safe devices for treating severely debilitating diseases. It will directly support the research work of a minority graduate student, who is an active member of the Society for Advancement of Chicanos and Native Americans in Science (SAGNAS). The student will receive training in computational fluid dynamics and experimental techniques for stimulation of ex vivo tissues by focused ultrasound. The outcomes of high-intensity therapeutic focused ultrasound (HITU) significantly depend on the presence of micrometer-size bubbles that can be formed in tissues as a result of acoustic cavitation. The oscillation of microbubbles in an ultrasound field generates mechanical stresses on nearby cells and tissues, leading, for example, to thrombolysis or transient opening of the blood-brain barrier (BBB) for drug delivery to brain tissue. The PI will develop a state-of-the-art computational model the collective dynamics of cavitation of lipid-coated microbubbles in blood vessels and tissues exposed to focused ultrasound. The model will account for tissue viscoelasticity and inhomogeneity and be validated against HITU experiments on rupture of explanted vessels, to determine the critical pressure and stresses on the vessel wall above which the vessel ruptures.

摘要：Khismatullin, Damir 提案编号：1641221 高强度聚焦超声最近作为一种无创电离辐射治疗方法得到了认可。人们正在探索它用于治疗癌症、神经系统疾病和循环系统相关的心血管疾病。为了避免永久性损伤并确定 HITU 设备的血管破裂阈值，将进行血管中气泡动力学实验和建模。该项目将推出一种用于 HITU 安全阈值评估的计算工具和新公式，使美国患者能够更快地获得安全设备来治疗严重衰弱的疾病。它将直接支持一名少数族裔研究生的研究工作，该研究生是奇卡诺人和美洲原住民科学促进会（SAGNAS）的活跃成员。学生将接受计算流体动力学和通过聚焦超声刺激离体组织的实验技术的培训。高强度聚焦超声治疗 (HITU) 的效果很大程度上取决于微米级气泡的存在，这些气泡可能因声空化而在组织中形成。超声场中微泡的振荡会对附近的细胞和组织产生机械应力，从而导致血栓溶解或血脑屏障 (BBB) 短暂打开，从而将药物输送到脑组织。 PI 将开发一种最先进的计算模型，研究暴露于聚焦超声的血管和组织中脂质涂层微泡空化的集体动力学。该模型将考虑组织粘弹性和不均匀性，并针对外植血管破裂的 HITU 实验进行验证，以确定血管壁上的临界压力和应力，高于该压力和应力，血管就会破裂。