TRR 134: Ingestive Behaviour: Homeostasis and Reward

TRR 134：摄入行为：稳态和奖励

基本信息

批准号：
222193485
负责人：
金额：
--
依托单位：
Universität Hamburg
依托单位国家：
德国
项目类别：
CRC/Transregios
财政年份：
2014
资助国家：
德国
起止时间：
2013-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/222193485?language=en
关键词：
TRR 134 Ingestive Behaviour Homeostasis

项目摘要

The incidence and prevalence of obesity continues to rise and is particularly observed in populations that are exposed to an unprecedented abundance of food. Against this background, it represents an urgent task to unravel the central nervous mechanisms that act to integrate the homeostatic and reward-associated neurocircuits encoding the behavioural portfolio relevant for food choice and intake. Based on the significant and exciting progress made in the first funding period, we will now expand our conceptual approach and efforts to systematically move towards a more system-based and translational research programme. To this end, we will position our goal to decipher the interaction between homeostatic and reward circuits in a broader context with regards to neuronal and functional interactions (level A). The analysis of this crosstalk will also include relevant models of social interaction and cue triggered/external eating behaviour in a more clinically oriented translational context (level B). Clearly defined intervention strategies to enable tackling these problems through neuromodulation, pharmacological means or targeted neurosurgical approaches will be employed (level C). Finally, human studies within the T-CRC will now benefit from a pheno- and genotypically well-characterized cohort in the Z2 project. The recruitment of normal individuals and individuals which are environmentally or genetically prone to altered eating behaviour is clearly essential for the experimental paradigms and targeted interventions of the next funding period.

肥胖症的发生率和流行率继续升高，在暴露于前所未有的食物中的人群中尤其观察到。在这种背景下，它代表了一项紧迫的任务，即揭示中枢神经机制，以整合稳态和奖励相关的神经通路，该神经通路编码与食物选择和摄入相关的行为组合。基于第一个融资期间取得的重大和令人兴奋的进步，我们现在将扩大我们的概念方法和努力，以系统地朝着基于系统的转化研究计划迈进。为此，我们将在更广泛的背景下，就神经元和功能相互作用（a级），在更广泛的背景下，在更广泛的背景下（级别），我们的目标将稳态和奖励电路之间的相互作用解密。该串扰的分析还将包括在更临床的转化环境（B级）中触发社会互动的相关模型和提示/外部饮食行为。明确定义的干预策略将采用神经调节，药理手段或有针对性的神经外科方法来解决这些问题（C级）。最后，T-CRC中的人类研究现在将受益于Z2项目中的表型和基因型良好的队列。在环境或遗传上容易改变饮食行为的正常人和个体对于下一个资金期间的实验范式和有针对性的干预措施显然至关重要。

项目成果

期刊论文数量（37）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Mesolimbic white matter connectivity mediates the preference for sweet food

DOI：
10.1038/s41598-019-40935-6
发表时间：
2019-03-13
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
Francke, Paul;Tiedemann, Lena J.;Brassen, Stefanie
通讯作者：
Brassen, Stefanie

Double transcranial direct current stimulation of the brain increases cerebral energy levels and systemic glucose tolerance in men

双经颅直流电刺激大脑可增加男性的脑能量水平和全身葡萄糖耐量

DOI：
10.1111/jne.12688
发表时间：
2019
期刊：
Journal of Neuroendocrinology
影响因子：
3.2
作者：
Wardzinski;Friedrichsen;Dannenberger;Kistenmacher;Melchert;Jauch-Chara;Oltmanns
通讯作者：
Oltmanns

Influences of Hunger, Satiety and Oral Glucose on Functional Brain Connectivity: A Multimethod Resting-State fMRI Study