权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

TRR 134: Ingestive Behaviour: Homeostasis and Reward

TRR 134：摄入行为：稳态和奖励

基本信息

批准号：
222193485
负责人：
金额：
--
依托单位：
Universität Hamburg
依托单位国家：
德国
项目类别：
CRC/Transregios
财政年份：
2014
资助国家：
德国
起止时间：
2013-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/222193485?language=en
关键词：
TRR 134 Ingestive Behaviour Homeostasis

项目摘要

The incidence and prevalence of obesity continues to rise and is particularly observed in populations that are exposed to an unprecedented abundance of food. Against this background, it represents an urgent task to unravel the central nervous mechanisms that act to integrate the homeostatic and reward-associated neurocircuits encoding the behavioural portfolio relevant for food choice and intake. Based on the significant and exciting progress made in the first funding period, we will now expand our conceptual approach and efforts to systematically move towards a more system-based and translational research programme. To this end, we will position our goal to decipher the interaction between homeostatic and reward circuits in a broader context with regards to neuronal and functional interactions (level A). The analysis of this crosstalk will also include relevant models of social interaction and cue triggered/external eating behaviour in a more clinically oriented translational context (level B). Clearly defined intervention strategies to enable tackling these problems through neuromodulation, pharmacological means or targeted neurosurgical approaches will be employed (level C). Finally, human studies within the T-CRC will now benefit from a pheno- and genotypically well-characterized cohort in the Z2 project. The recruitment of normal individuals and individuals which are environmentally or genetically prone to altered eating behaviour is clearly essential for the experimental paradigms and targeted interventions of the next funding period.

肥胖症的发病率和流行率继续上升，特别是在暴露于前所未有的丰富食物的人群中观察到。在这种背景下，它代表了一个紧迫的任务，以解开中枢神经机制，采取行动，以整合的自我平衡和奖励相关的神经回路编码的行为组合相关的食物选择和摄入。在第一个资助期取得的重大和令人兴奋的进展的基础上，我们现在将扩大我们的概念方法和努力，系统地走向更系统的和转化的研究计划。为此，我们将定位我们的目标，在更广泛的背景下，关于神经元和功能的相互作用（A级），破译稳态和奖励电路之间的相互作用。这种串扰的分析还将包括在更临床导向的翻译背景下（B级）的社交互动和线索触发/外部进食行为的相关模型。将采用明确定义的干预策略，通过神经调节、药理学手段或有针对性的神经外科方法来解决这些问题（C级）。最后，T-CRC中的人类研究现在将受益于Z2项目中表型和基因型特征良好的队列。招募正常个体和在环境或遗传上容易改变饮食行为的个体显然对下一个资助期的实验范式和有针对性的干预至关重要。

项目成果

期刊论文数量（37）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Double transcranial direct current stimulation of the brain increases cerebral energy levels and systemic glucose tolerance in men

双经颅直流电刺激大脑可增加男性的脑能量水平和全身葡萄糖耐量

DOI：
10.1111/jne.12688
发表时间：
2019
期刊：
Journal of Neuroendocrinology
影响因子：
3.2
作者：
Wardzinski;Friedrichsen;Dannenberger;Kistenmacher;Melchert;Jauch-Chara;Oltmanns
通讯作者：
Oltmanns

Mesolimbic white matter connectivity mediates the preference for sweet food