CAREER: The mechanics and control of cell dispersal

PI: Guasto， Jeffrey提案号：1554095这个职业提案的重点是研究粘性流体的材料特性如何影响细胞的运动。目标是为细胞运输的广泛领域提供见解，并了解影响细胞游动的不同物理过程如何调节多种生物功能。这项研究的结果可能会对公共卫生、生态、工程和医学等多个领域产生影响。将研究对生育治疗和疾病传播机制具有重要意义的现象。虽然该领域的大多数先前工作都集中在牛顿流体（主要是水生环境）中游泳的情况，以及理想形状的游泳者，但这是一项研究真实细菌细胞和非牛顿流体（如宫颈粘液）中游泳的建议。本文还提出了一种基于高速成像的新型纳米级实验技术，用于监测每个细胞的运动。除了研究生和本科生培训外，还将与塔夫茨工程教育和推广中心合作开发一个新的推广项目（STOMP），该项目将基于使用高速成像技术。

PI: Guasto, Jeffrey Proposal Number: 1554095 This CAREER proposal is focused on the investigation of how the material properties of viscous fluids affect the motion of cells. The goal is to contribute insights into the broad field of cell transport, and to understand how different physical processes affecting the swimming of cells can regulate a host of diverse biological functions. The results of this research could have an impact on multiple fields, including public health, ecology, engineering and medicine. Phenomena that are important to the treatment of fertility and the mechanisms of spreading of disease will be investigated.While most prior work in this area has been focused on cases of swimming in Newtonian fluids (aquatic environments mainly), and ideally shaped swimmers, this is a proposal to investigate the swimming of real bacteria cells and in non-Newtonian fluids, like cervical mucus. The development of a novel nano-scale experimental technique, based on high speed imaging, for the monitoring of the motion of each individual cell is also proposed. In addition to graduate and undergraduate student training, a new outreach program (STOMP) will be developed in collaboration with Tufts Center for Engineering Education and Outreach that will be based on using high-speed imaging.