Tunable Biocompatible and Biodegradable Thermoresponsive Polycaprolactones

可调节的生物相容性和可生物降解的热响应聚己内酯

• 批准号: 1609880
• 负责人: Mihaela Stefan
• 金额: $ 43.5万
• 依托单位: University of Texas at Dallas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1609880&HistoricalAwards=false
• 关键词: Tunable; Biocompatible; Biodegradable; Thermoresponsive; Polycaprolactones

The Macromolecular, Supramolecular and Nanochemistry Program in the NSF Division of Chemistry supports Professors Mihaela C. Stefan and Michael C. Biewer of the University of Texas at Dallas to develop biodegradable and biocompatible polymers. The polymers of interest contain both water-friendly (hydrophilic) and water repellent (hydrophobic) segments can assemble in water to form core-shell structures in which the water-insoluble molecules can be loaded. The most attractive property of these polymers is their degradation in water media making them environmentally friendly materials. The project provides training to graduate and undergraduate students in the synthesis and characterization of organic compounds and polymers. High school students are given the opportunity to contribute in a summer research project to learn skills in a chemistry laboratory environment.The objective of this proposed research is to develop polycaprolactone amphiphilic block copolymers that are biodegradable, biocompatible, and thermoresponsive. The research team aims to control the thermoresponsivity of the amphiphilic block copolymers by varying the ratio between the hydrophilic oligoethylene glycol substituted polycaprolactone hydrophilic block and the hydrophobic polycaprolactone block. To understand the dependence of the degradation rate on the structure of the block copolymers and their composition, the team investigates the effects of changing the linkage of the substituent on the monomers from ether to thioether, and from ester to thioester, on the polymer degradation rate. In addition, investigation of the self-assembly of the synthesized amphiphlic polycaprolactone block copolymers is conducted to obtain a correlation between the molecular structure and the size of micelles.

NSF化学部的大分子、超分子和纳米化学项目支持Mihaela C. Stefan和Michael C.位于达拉斯的得克萨斯大学的Biewer开发了可生物降解和生物相容的聚合物。所关注的聚合物含有水友好（亲水）和水排斥（疏水）片段两者，可以在水中组装以形成核-壳结构，其中可以装载水不溶性分子。 这些聚合物最吸引人的特性是它们在水介质中的降解，使它们成为环境友好材料。 该项目为研究生和本科生提供有机化合物和聚合物合成和表征方面的培训。 高中生有机会参与一个暑期研究项目，在化学实验室环境中学习技能。这项研究的目标是开发可生物降解、生物相容和温敏的聚己内酯两亲性嵌段共聚物。 该研究小组旨在通过改变亲水性低聚乙二醇取代的聚己内酯亲水性嵌段和疏水性聚己内酯嵌段之间的比例来控制两亲性嵌段共聚物的温度响应性。 为了了解降解速率对嵌段共聚物结构及其组成的依赖性，研究小组研究了将单体上取代基的连接从醚变为硫醚，从酯变为硫酯对聚合物降解速率的影响。 此外，研究了所合成的两亲性聚己内酯嵌段共聚物的自组装行为，得到了分子结构与胶束尺寸之间的关系。