MRI: Acquisition of an Accurate-Mass LC-QTOF Mass Spectrometer for Advancing Environment, Life Sciences, Bioenergy and Chemistry Research, Education and Training

MRI：购买精确质量 LC-QTOF 质谱仪以促进环境、生命科学、生物能源和化学研究、教育和培训

• 批准号: 1626112
• 负责人: Matt Whiles
• 金额: $ 38.35万
• 依托单位: Southern Illinois University at Carbondale
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1626112&HistoricalAwards=false
• 关键词: MRI; Acquisition; Accurate; Mass; LC

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Da Chen from Southern Illinois University Carbondale (SIUC) and colleagues Michael Lydy, Yanna Liang and Dale Hales have acquired an accurate mass LC-QTOF MS (liquid chromatograph quadrupole time-of-flight mass spectrometer). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex mixture (matrix). In a typical experiment, the components flow into a mass spectrometer where they are broken apart into charged species and measured. This is highly sensitive technique allows detection and determination of the structure of molecules. A mass spectromter coupled with a liquid chromatograph provides additional structure identification power by separating mixtures of compounds before they reach the mass spectrometer. This instrument acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse students in research using this modern analytical technique. The project also provides training opportunities to a large number of SIUC undergraduate students through a variety of programs, such as the Research Enriched Academic Challenge (REACH) Program, Undergraduate Assistantship Program, McNair Post-baccalaureate Achievement Program, Illinois Louis Strokes Alliance for Minority Participation (ILSAMP), as well as the National Science Foundation Research Experiences for Undergraduates (REU) program.The award is aimed at enhancing research and education at all levels, especially in areas such as: (a) studying the environmental presence of chemicals of emerging concern and exposure in wildlife; (b) analyzing environmental transformation of emerging contaminants; (c) looking at the fate and effects of antibiotics on freshwater communities; (d) assessing the ecological impact of neonicotinoid insecticides; (e) searching for chemical signatures of cyanobacterial species and environmental conditions; (f) developing spatially resolved, tissue-specific chemical profiles of emerging contaminants in Great Lakes trout.

在主要研究仪器计划（MRI）和化学研究仪器计划（CRIF）的支持下，来自南伊利诺伊大学卡本代尔（SIUC）的Da Chen教授及其同事Michael Lydy，Yanna Liang和Dale Hales获得了准确的质量LC-QTOF MS（液相色谱四极杆飞行时间质谱仪）。一般来说，质谱法（MS）是用于识别和表征复杂混合物（基质）中嵌入的少量化学物质的关键分析方法之一。在一个典型的实验中，组分流入质谱仪，在那里它们被分解成带电物质并被测量。这是一种高灵敏度的技术，可以检测和确定分子的结构。与液相色谱仪耦合的质谱仪通过在化合物的混合物到达质谱仪之前分离它们来提供额外的结构鉴定能力。该仪器的收购加强了大学和区域的研究基础设施。该仪器通过使用这种现代分析技术让不同的学生参与研究来扩大参与范围。该项目还通过各种计划为大量SIUC本科生提供培训机会，如研究丰富的学术挑战（REACH）计划，本科生助学金计划，麦克奈尔学士后成就计划，伊利诺伊州路易斯中风少数民族参与联盟（ILSAMP），以及国家科学基金会本科生研究经验（REU）计划。该奖项旨在加强各级研究和教育，特别是在以下领域：（a）研究新出现的令人关切的化学品在环境中的存在情况以及野生生物接触这些化学品的情况;（B）分析新出现的污染物在环境中的转化情况;（c）研究抗生素对淡水社区的最终结果和影响;（d）评估类烟碱杀虫剂对生态的影响;（e）寻找蓝细菌物种和环境条件的化学特征;（f）对五大湖鳟鱼中新出现的污染物进行空间分辨、组织特异性化学分析。