MRI: Acquisition of an Accurate-Mass LC-QTOF Mass Spectrometer for Advancing Environment, Life Sciences, Bioenergy and Chemistry Research, Education and Training

在重大研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，南伊利诺伊大学卡本代尔大学(SIUC)的陈达教授及其同事Michael Lydy、Yanna Leung和Dale Hales获得了准确的质量LC-QTOF MS(液体色谱仪四极飞行时间质谱仪)。通常，质谱仪(MS)是用于识别和表征镶嵌在复杂混合物(基质)中的少量化学物种的关键分析方法之一。在一个典型的实验中，这些成分流入质谱仪，在那里它们被分解成带电物种并进行测量。这是一种高度灵敏的技术，可以检测和确定分子结构。质谱仪与液相色谱仪相结合，通过在化合物到达质谱计之前将混合物分离来提供额外的结构识别能力。这一仪器采购加强了该大学和区域地区的研究基础设施。该仪器通过让不同的学生参与到使用这种现代分析技术的研究中来扩大参与。该项目还通过各种项目为大量SIUC本科生提供培训机会，如丰富研究学术挑战(REACH)计划、本科生助学金计划、麦克奈尔学士后成就计划、伊利诺伊州路易斯中风少数群体参与联盟(ILSAMP)以及国家科学基金会本科生研究经历(REU)计划。该奖项旨在加强各级的研究和教育，特别是在以下领域：(A)研究野生动物中新出现的关注和暴露的化学物质的环境存在；(B)分析新出现的污染物的环境变化；(C)研究抗生素对淡水群落的去向和影响；(D)评估新烟碱类杀虫剂的生态影响；(E)寻找蓝藻物种的化学特征和环境条件；(F)为大湖区鲑鱼新出现的污染物制订空间分辨、特定组织的化学概况。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Da Chen from Southern Illinois University Carbondale (SIUC) and colleagues Michael Lydy, Yanna Liang and Dale Hales have acquired an accurate mass LC-QTOF MS (liquid chromatograph quadrupole time-of-flight mass spectrometer). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex mixture (matrix). In a typical experiment, the components flow into a mass spectrometer where they are broken apart into charged species and measured. This is highly sensitive technique allows detection and determination of the structure of molecules. A mass spectromter coupled with a liquid chromatograph provides additional structure identification power by separating mixtures of compounds before they reach the mass spectrometer. This instrument acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse students in research using this modern analytical technique. The project also provides training opportunities to a large number of SIUC undergraduate students through a variety of programs, such as the Research Enriched Academic Challenge (REACH) Program, Undergraduate Assistantship Program, McNair Post-baccalaureate Achievement Program, Illinois Louis Strokes Alliance for Minority Participation (ILSAMP), as well as the National Science Foundation Research Experiences for Undergraduates (REU) program.The award is aimed at enhancing research and education at all levels, especially in areas such as: (a) studying the environmental presence of chemicals of emerging concern and exposure in wildlife; (b) analyzing environmental transformation of emerging contaminants; (c) looking at the fate and effects of antibiotics on freshwater communities; (d) assessing the ecological impact of neonicotinoid insecticides; (e) searching for chemical signatures of cyanobacterial species and environmental conditions; (f) developing spatially resolved, tissue-specific chemical profiles of emerging contaminants in Great Lakes trout.