MRI: Acquisition of a 400 MHz NMR Spectrometer for Use in Research and Research Training

MRI：采购 400 MHz NMR 波谱仪用于研究和研究培训

• 批准号: 1626523
• 负责人: Adam Mosey
• 金额: $ 39.95万
• 依托单位: Lake Superior State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1626523&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; NMR

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Adam Mosey from Lake Superior State University and colleagues R. Marshall Werner, Steven Johnson and Martha Hutchens have acquired a 400 MHz NMR spectrometer. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the study of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry, forensics and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate students via independent student research and traditional academic coursework as well as researchers and students from the Bay Mills Tribal Community College that has a large Native American enrollment.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) characterizing the products and mechanism of an enantioselective imadazoline annulation reaction; (b) characterizing Evans-based chiral auxiliary enolates and their resulting aldol reaction products; (c) investigating the anti-microbial properties of 3,4-dihydroquinazolines and (d) exploring the forensic chemistry of compounds, and (e) preparing isotopically-labeled synthetic cannabinoids.

在主要研究仪器计划（MRI）的奖励和化学研究仪器计划（CRIF）的支持下，来自苏必利尔湖上级州立大学的Adam Mosey教授及其同事R.马歇尔维尔纳，史蒂芬约翰逊和玛莎Hutterman获得了400兆赫核磁共振光谱仪。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及生物相关物种的研究。一般来说，核磁共振（NMR）光谱是化学家研究分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。 这些NMR研究的结果对合成有机/无机化学、材料化学、法医学和生物化学产生了影响。该仪器是教学的一个组成部分，以及由本科生通过独立的学生研究和传统的学术课程，以及来自海湾米尔斯部落社区学院的研究人员和学生进行的研究，该学院有大量的美国原住民入学。该奖项旨在加强各级研究和教育，特别是在以下领域，例如（a）表征对映选择性咪唑啉成环反应的产物和机理;（B）表征基于Evans的手性辅助烯醇化物和它们得到的羟醛缩合反应产物;（c）研究3，4-二氢喹唑啉的抗微生物性质和（d）探索化合物的法医化学，和（e）制备同位素标记的合成大麻素。