I-Corps: Cold Plasma Cancer Therapy

I-Corps：冷等离子体癌症治疗

• 批准号: 1637906
• 负责人: Michael Keidar
• 金额: $ 5万
• 依托单位: George Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2016-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1637906&HistoricalAwards=false
• 关键词: Corps; Cold; Plasma; Cancer; Therapy

Cold atmospheric plasma (CAP) is a new and fascinating type of plasmas having tremendous potential in medicine and nanotechnology. One of the most promising applications of CAP is the cancer therapy. CAP selectively affect cancer cells and lead to tumor ablation. Successful conduction of this project would have tremendous impact on many important sectors of the national economy including medical equipment, and scientific devices. This I-Corps project will serve as an excellent vehicle for undergraduate and graduate education in the field of plasma medicine and commercialization of medical devices. This I-Corps team will make a concerted effort to involve women and under-represented minority students in this project by working closely with corresponded student organizations at the George Washington University.The fundamental significance of the proposed work is in exploring medical action of CAP, in particular, CAP interaction with tumor. To this end a wide spectrum of diagnostic instrumentations and chemical and biological sensors will be employed. Technical part of the project will be focused on development of a prototype system for clinical trials. During the I-Corps program, in addition to customer discovery, the team will be focused on building a prototype device that will generate cold plasma as well as consumable probe that will be used to deliver CAP to tissue. The prototype device will be tested in vitro on various cell lines. In addition the team will initiate new series of animal study using nude mice. The team also intends to initiate discussions with Federal Drug Administration on the necessary steps to approve this device for clinical use.

冷大气等离子体（CAP）是一种新型且引人入胜的等离子体，在医学和纳米技术方面具有巨大的潜力。 CAP最有希望的应用之一是癌症治疗。帽有选择地影响癌细胞并导致肿瘤消融。成功地进行该项目将对包括医疗设备和科学设备在内的许多重要部门产生巨大影响。这个I-Corps项目将成为血浆医学领域的本科和研究生教育和医疗设备商业化的绝佳工具。这支I-Corps团队将通过与乔治华盛顿大学的相应学生组织紧密合作，使妇女和代表性不足的少数民族学生参与该项目。拟议工作的基本意义在于探索CAP的基本意义，尤其是与Tumor的CAP互动。为此，将采用广泛的诊断仪器以及化学和生物传感器。该项目的技术部分将集中于开发用于临床试验的原型系统。在I-Corps计划期间，除了发现客户发现外，该团队还将专注于建立一种原型设备，该设备将产生冷等离子体以及可消耗量的探针，该探针将用于将帽子覆盖到组织中。原型设备将在各种细胞系上进行体外测试。此外，该团队将使用裸鼠启动新的动物研究系列。该团队还打算就批准该设备供临床使用的必要步骤进行与联邦药物管理局的讨论。