I-Corps: Point-of-Care Micro Biochip for Cancer Diagnostics

I-Corps项目的广泛影响/商业潜力主要集中在癌症早期诊断的社会需求以及疾病检测和诊断的商业应用市场。癌症仍然是美国第二大常见死因，占美国死亡人数的近1/4。癌症的早期发现可以加强预防措施，提高疾病的治愈率，降低医疗成本，最终提高患者的生活质量。癌症诊断过程可以是使用护理点(POC)微生物芯片技术的简单自我评估过程。因此，任何需要诊断癌症存在和严重程度的人，都可以通过POC生物芯片设备进行简单的自我检查。生物芯片在疾病诊断、药物输送、“芯片上的器官”和“芯片上的实验室”等生物医学设备中也有着巨大的应用潜力，由于其简单、快速和廉价的方法，它比大多数复杂的诊断过程和复杂的昂贵设备更具优势。这个i-Corps项目的主要目的是将可以诊断癌症的护理点(POC)微型生物芯片技术商业化。为了实现对特定癌症类型的早期检测，生物芯片结合了一套高度敏感和特定的癌症生物标志物和传感技术。为了增加传感能力，生物芯片被制造成带有微通道，这些微通道被设计成在没有任何外部来源的情况下产生血流。利用生物芯片传感技术捕捉生物反应，该技术是利用生物芯片中的高灵敏纳米电路设计开发的。此外，根据信号输出的强度来感知癌症的严重程度。因此，可以使用微生物芯片来诊断癌症及其严重程度。

The broader impact/commercial potential of this I-Corps project are primarily focused on the societal need for early diagnosis of cancer and the market for commercial applications of disease detection and diagnosis. Cancer remains the second most common cause of death in the US, accounting for nearly 1 of every 4 deaths. The early detection of cancers can enhance preventive measures, increase curability of the disease, reduces health care costs and finally improves the quality of life for patients. The cancer diagnosis process can be a simple self-evaluation process using the point-of-care (POC) micro biochip technology. Therefore, anyone who needs to diagnose the existence and severity of cancer, can perform simple self-check by a POC biochip device. The biochip also has a huge potential in numerous applications in disease diagnosis, drug delivery, 'organ on a chip' and 'lab on a chip' biomedical devices with advantages over the most of the complicated diagnosis processes and sophisticated expensive equipment due to its simple, quick and inexpensive methodology.This I-Corps project is primarily intended to commercialize the point-of-care (POC) micro biochip technology which can diagnose cancer. To achieve the early detection of specific cancer type, the biochip is incorporated with a highly sensitive and specific set of cancer biomarkers and the sensing technology. To increase the sensing capability, the biochip is fabricated with microchannels that are designed to create blood flow without the any external source. The biological reaction is captured using the biochip sensing technology that is developed using highly sensitive nano-circuit design in the biochip. Also, the cancer severity is sensed depending on the intensity of the signal output. Therefore, the cancer and its severity can be diagnosed using the micro biochip.