NSF Career: Enamine-Metal Lewis Acid Bifunctional Catalysts for Asymmetric Organic Transformations

NSF 职业:用于不对称有机转化的烯胺-金属路易斯酸双功能催化剂

基本信息

  • 批准号:
    1664708
  • 负责人:
  • 金额:
    $ 8.11万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-21 至 2017-02-28
  • 项目状态:
    已结题

项目摘要

Professor Hong Wang of Miami University Oxford Campus is supported by the Chemical Catalysis (CAT) Program in the Division of Chemistry to develop bifunctional catalysts combining a metal center with an organocatalytic center on a single molecule for potential applications in asymmetric organic transformations. Bifunctional enamine-metal Lewis acid catalysts will be synthesized and used for asymmetric carbon-carbon and carbon-heteroatom bond forming reactions which cannot be achieved without the synergistic action of the two catalytic centers. Direct aldol condensations with ketones and inverse-electron-demand hetero-Diels-Alder reactions will be investigated. The catalyst design allows for the combination of different amine bases with different metals, which broadens the spectrum of applicability of these bifunctional catalytic systems to a wide range of organic reactions. The development of Lewis acid-Lewis base bifunctional systems is challenging because the acid and the base are prone to self-quenching and inactivation. The proposed research promises to circumvent this problem by judicious molecular architecture with sufficient flexibility to bring the organic base and the metal Lewis acid into close proximity but with enough rigidity and steric hindrance to prevent their binding. The proposed research could significantly impact asymmetric catalysis and the synthesis of fine chemicals and pharmaceuticals. The results will be integrated into a new graduate course in catalysis and an outreach plan will be implemented to provide summer research experience to minority undergraduate students and their teachers from Texas A&M University-Kingsville and to high school teachers from area high schools.
迈阿密大学牛津校区的Hong Wang教授得到化学系化学催化(CAT)项目的支持,开发了在单个分子上结合金属中心和有机催化中心的双功能催化剂,用于不对称有机转化的潜在应用。将合成双官能烯胺-金属刘易斯酸催化剂,并将其用于不对称碳-碳和碳-杂原子键形成反应,如果没有两个催化中心的协同作用,这些反应就不能实现。我们将研究直接羟醛缩合反应和反电子需求的异Diels-桤木反应。催化剂设计允许不同胺碱与不同金属的组合,这拓宽了这些双功能催化体系对广泛的有机反应的适用性范围。刘易斯酸-刘易斯碱双功能体系的开发具有挑战性,因为酸和碱易于自猝灭和失活。拟议中的研究有望通过明智的分子结构来规避这个问题,这些分子结构具有足够的灵活性,可以使有机碱和金属刘易斯酸非常接近,但具有足够的刚性和空间位阻,可以防止它们结合。这项研究可能会对不对称催化以及精细化学品和药物的合成产生重大影响。研究结果将被纳入一个新的催化研究生课程,并将实施一项推广计划,为德克萨斯州A M大学金斯维尔分校的少数民族本科生及其教师和地区高中的高中教师提供夏季研究经验。

项目成果

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Hong Wang其他文献

Uplink Performance Analysis in Multi-tier Heterogeneous Cellular Networks with Power Control and Biased User Association
具有功率控制和偏置用户关联的多层异构蜂窝网络中的上行链路性能分析
  • DOI:
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    4.1
  • 作者:
    Han Hu;Hong Wang;Qi Zhu;Ziyu Pan
  • 通讯作者:
    Ziyu Pan
On STAR-RIS-Aided NOMA With Multi-Group Detection
具有多组检测的 STAR-RIS 辅助 NOMA
  • DOI:
    10.1109/lwc.2023.3303414
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    6.3
  • 作者:
    Shen Fu;Hong Wang;Haitao Zhao;Haochun Ma
  • 通讯作者:
    Haochun Ma
Control of networked traffic flow distribution: a stochastic distribution system perspective
网络流量分配的控制:随机分配系统的角度
Composite robust H1 control for uncertain stochastic nonlinear systems with state delay via disturbance observer
基于扰动观测器的状态延迟不确定随机非线性系统的复合鲁棒H1控制
A Novel Optical See-Through Head-Mounted Display with Occlusion and Intensity Matching Support
具有遮挡和强度匹配支持的新型光学透视头戴式显示器

Hong Wang的其他文献

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{{ truncateString('Hong Wang', 18)}}的其他基金

CAS: Highly Interacting Panchromatic Push-Pull Systems: Symmetry Breaking and Quantum Coherence in Electron Transfer
CAS:高度交互的全色推拉系统:电子转移中的对称破缺和量子相干性
  • 批准号:
    2345836
  • 财政年份:
    2024
  • 资助金额:
    $ 8.11万
  • 项目类别:
    Standard Grant
Oscillatory Integrals and Falconer's Conjecture
振荡积分和福尔科纳猜想
  • 批准号:
    2424015
  • 财政年份:
    2024
  • 资助金额:
    $ 8.11万
  • 项目类别:
    Standard Grant
CAREER: Oscillatory Integrals and the Geometry of Projections
职业:振荡积分和投影几何
  • 批准号:
    2238818
  • 财政年份:
    2023
  • 资助金额:
    $ 8.11万
  • 项目类别:
    Continuing Grant
Oscillatory Integrals and Falconer's Conjecture
振荡积分和福尔科纳猜想
  • 批准号:
    2055544
  • 财政年份:
    2021
  • 资助金额:
    $ 8.11万
  • 项目类别:
    Standard Grant
Oscillatory Integrals and Falconer's Conjecture
振荡积分和福尔科纳猜想
  • 批准号:
    2141426
  • 财政年份:
    2021
  • 资助金额:
    $ 8.11万
  • 项目类别:
    Standard Grant
Variable-Order Fractional Partial Differential Equations: Computation, Analysis, and Application
变阶分数阶偏微分方程:计算、分析与应用
  • 批准号:
    2012291
  • 财政年份:
    2020
  • 资助金额:
    $ 8.11万
  • 项目类别:
    Standard Grant
Cooperative Enamine-Hard Metal Lewis Acid Catalysis for New Asymmetric Organic Transformations
烯胺-硬金属路易斯酸协同催化新的不对称有机转化
  • 批准号:
    1954422
  • 财政年份:
    2020
  • 资助金额:
    $ 8.11万
  • 项目类别:
    Continuing Grant
CAS: Near-IR Absorbing Intramolecular Charge Transfer Complexes: Syntheses, Symmetry-Breaking Charge Transfer, and Charge Transfer Reversal by External Stimuli
CAS:近红外吸收分子内电荷转移复合物:合成、对称破坏电荷转移和外部刺激引起的电荷转移逆转
  • 批准号:
    2000988
  • 财政年份:
    2020
  • 资助金额:
    $ 8.11万
  • 项目类别:
    Standard Grant
Fractional Partial Differential Equations and Related Nonlocal Models: Fast Numerical Methods, Analysis, and Application
分数阶偏微分方程及相关非局部模型:快速数值方法、分析和应用
  • 批准号:
    1620194
  • 财政年份:
    2016
  • 资助金额:
    $ 8.11万
  • 项目类别:
    Standard Grant
Development and analysis of fast numerical methods for fractional diffusion and advection-diffusion equations
分数扩散和平流扩散方程快速数值方法的开发和分析
  • 批准号:
    1216923
  • 财政年份:
    2012
  • 资助金额:
    $ 8.11万
  • 项目类别:
    Standard Grant

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