CBET-EPSRC: Hybrid organic-CMOS devices for optogenetic stimulation and lens-free fluorescence imaging of the brain

CBET-EPSRC：用于脑部光遗传学刺激和无透镜荧光成像的混合有机 CMOS 设备

• 批准号: 1706207
• 负责人: Kenneth Shepard
• 金额: $ 30万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1706207&HistoricalAwards=false
• 关键词: CBET; EPSRC; Hybrid; organic; CMOS

This collaborative proposal by Dr. Shepard from Columbia University and an international team of researchers from the UK, will develop an optical imaging approach to study freely-behaving animals and potentially humans. The proposal explores original and transformative approaches for overcoming current barriers of functional imaging of the brain. If successful, the platform developed by this project will be critical to many research projects, which will further understanding of the functioning of the brain as well as various brain disease mechanismsThe approach builds on the development of a dense 3D lattice of emitters and detectors embedded onto ultra-narrow implantable neural probes. The proposal includes 3 aims comprising (1) the development of fully integrated high-density optogenetic stimulators, (2) development of time-gated fluorescence detection of lens-free neuronal recordings and (3) in vitro and in vivo characterization and validation of the system. The work includes educational and outreach activities, including; integration of educational material into courses on neuroscience, bioelectronics and biophotonics at Columbia University and at St. Andrews.

这项由哥伦比亚大学的谢泼德博士和来自英国的一个国际研究小组共同提出的合作提案，将开发一种光学成像方法来研究自由行为的动物和潜在的人类。该提案探索了克服当前大脑功能成像障碍的原创和变革性方法。如果成功，该项目开发的平台将对许多研究项目至关重要，这将进一步了解大脑的功能以及各种大脑疾病机制该方法建立在开发嵌入超窄植入式神经探针的发射器和检测器的密集3D晶格的基础上。该提案包括3个目标，包括（1）开发完全集成的高密度光遗传学刺激器，（2）开发无透镜神经元记录的时间门控荧光检测，以及（3）系统的体外和体内表征和验证。 这项工作包括教育和外联活动，包括：将教育材料纳入哥伦比亚大学和圣安德鲁斯的神经科学、生物电子学和生物光子学课程。

项目成果

Optogenetic stimulation probes with single-neuron resolution based on organic LEDs monolithically integrated on CMOS

基于单片集成在 CMOS 上的有机 LED 的具有单神经元分辨率的光遗传学刺激探针

• DOI: 10.1038/s41928-023-01013-y
• 发表时间: 2023
• 期刊: Nature Electronics
• 影响因子: 34.3
• 作者: Taal, Adriaan J.;Uguz, Ilke;Hillebrandt, Sabina;Moon, Chang-Ki;Andino-Pavlovsky, Victoria;Choi, Jaebin;Keum, Changmin;Deisseroth, Karl;Gather, Malte C.;Shepard, Kenneth L.
• 通讯作者: Shepard, Kenneth L.

High‐Density Integration of Ultrabright OLEDs on a Miniaturized Needle‐Shaped CMOS Backplane

在微型针形 CMOS 背板上高密度集成超亮 OLED

• DOI: 10.1002/adma.202300578
• 发表时间: 2023
• 期刊: Advanced Materials
• 影响因子: 29.4
• 作者: Hillebrandt, Sabina;Moon, Chang‐Ki;Taal, Adriaan J.;Overhauser, Henry;Shepard, Kenneth L.;Gather, Malte C.
• 通讯作者: Gather, Malte C.