I-Corps: High Frame-rate Fluorescence Lifetime Imaging Microscopy

I-Corps：高帧率荧光寿命成像显微镜

• 批准号: 1243899
• 负责人: Kenneth Shepard
• 金额: $ 5万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1243899&HistoricalAwards=false
• 关键词: Corps; Frame; rate; Fluorescence; Lifetime

The High Frame Rate Fluorescence Lifetime Imaging Microscopy system promises new fluorescence imaging capabilities at costs dramatically lower than current systems. By integrating detectors and converters on a single platform, frame rates in excess of 100 frames/second at a production cost of under $1000 should be possible. This compares with image acquisition times of a few seconds per frame at near 100 times the cost fopr currently-available systems. This proposal will assist the team in assessing the commercial viability of the research that was previously sponsored by NSF. If successfully commercialized, the team will deliver a new technology that advances the state of the art in fluorescence lifetime imaging microscopy. This advancement will allow measurements of dynamics of fluorescence lifetimes with an inexpensive and simple system. These measurements could lead to further advances in microscopy as well as the development of new medical diagnostic systems. In addition to the scientific advances that would be possible with widespread adoption of the system, there would also be positive economic impacts that would result from transitioning the hardware from the lab and ramping production.

高帧率荧光寿命成像显微镜系统承诺新的荧光成像能力，成本大大低于目前的系统。通过在单个平台上集成检测器和转换器，以低于1000美元的生产成本超过100帧/秒的帧速率应该是可能的。这与每帧几秒的图像采集时间相比，其成本是当前可用系统的近100倍。该提案将帮助该团队评估先前由NSF赞助的研究的商业可行性。如果成功商业化，该团队将提供一种新技术，推动荧光寿命成像显微镜的发展。这一进步将允许测量的荧光寿命的动力学与廉价和简单的系统。这些测量可能会导致显微镜的进一步发展以及新的医疗诊断系统的发展。除了广泛采用该系统可能带来的科学进步外，从实验室转移硬件和提高生产也会产生积极的经济影响。