MRI: Upgrade of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

MRI：500 MHz 核磁共振 (NMR) 波谱仪的升级

• 批准号: 1725883
• 负责人: Kerney Glover
• 金额: $ 47.05万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1725883&HistoricalAwards=false
• 关键词: MRI; Upgrade; 500; MHz; Nuclear

This award is supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation Programs. Professor Kerney Glover from Lehigh University and colleagues Bryan Berger and Damien Thevenin are upgrading a console for a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer and also have equipped the spectrometer with a cryoprobe. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as studies of biologically-relevant species. In general, NMR spectroscopy is a powerful tools available to chemists for the structural study of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the changing interactions between molecules in solution. The results from these NMR studies may have an impact in synthetic organic/inorganic chemistry, materials chemistry, and biochemistry. This instrument is an integral part of teaching as well as research performed by graduate and undergraduate students via independent student research and traditional academic coursework. The spectrometer is used to support academic institutions members of the Lehigh Valley Association of Independent Colleges such as Lafayette College, Kutztown University, Cedar Crest College, DeSales University, Moravian College and Muhlenberg College. Students from these institutions can enroll in an advanced laboratory class that utilizes the instrument.This NMR spectrometer enhances research and education at all levels. It aids researchers studying the molecular determinants for the homodimerization of the receptor protein-tyrosine phosphatase J and the structure and topology of the protein caveolin-1 (as well as mutants of caveolin-1.) The spectrometer is also used for the determination of the structure of the RAMP1 transmembrane domain.

该奖项得到了主要的研究工具（MRI）和化学研究工具计划的支持。利哈伊大学（Lehigh University）和同事布莱恩·伯格（Bryan Berger）和达米安·塞维宁（Damien Thevenin）的Kerney Glover教授正在为500 MHz核磁共振（NMR）光谱仪升级控制台，并为光谱仪配备了冷冻螺旋光仪。该光谱仪允许在各种领域进行研究，例如加速具有重要经济意义的化学反应的领域，以及对生物学与生物学相关的物种的研究。通常，NMR光谱是一种可用于分子结构研究的强大工具。它用于识别未知物质，以表征分子内原子的特定排列，并研究溶液中分子之间不断变化的相互作用。 这些NMR研究的结果可能会影响合成有机/无机化学，材料化学和生物化学。该乐器是教学的组成部分，也是研究生和本科生通过独立学生研究和传统学术课程进行的研究。光谱仪用于支持Lehigh Valley独立学院的学术机构，例如Lafayette College，Kutztown University，Cedar Crest College，Desales College，Desales University，Moravian College和Muhlenberg College。 这些机构的学生可以参加使用该工具的高级实验室课程。该NMR光谱仪可以在各个层面上增强研究和教育。它有助于研究分子决定因素的研究人员，用于受体蛋白 - 酪氨酸磷酸酶J的均匀化以及蛋白质可窝蛋白-1的结构和拓扑结构（以及卡韦诺蛋白-1的突变体）。光谱仪也用于确定RAMP1 Transmbrane transmbrane dramembrane domain的结构。