MRI: Upgrade of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

MRI：500 MHz 核磁共振 (NMR) 波谱仪的升级

• 批准号: 1725883
• 负责人: Kerney Glover
• 金额: $ 47.05万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1725883&HistoricalAwards=false
• 关键词: MRI; Upgrade; 500; MHz; Nuclear

This award is supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation Programs. Professor Kerney Glover from Lehigh University and colleagues Bryan Berger and Damien Thevenin are upgrading a console for a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer and also have equipped the spectrometer with a cryoprobe. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as studies of biologically-relevant species. In general, NMR spectroscopy is a powerful tools available to chemists for the structural study of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the changing interactions between molecules in solution. The results from these NMR studies may have an impact in synthetic organic/inorganic chemistry, materials chemistry, and biochemistry. This instrument is an integral part of teaching as well as research performed by graduate and undergraduate students via independent student research and traditional academic coursework. The spectrometer is used to support academic institutions members of the Lehigh Valley Association of Independent Colleges such as Lafayette College, Kutztown University, Cedar Crest College, DeSales University, Moravian College and Muhlenberg College. Students from these institutions can enroll in an advanced laboratory class that utilizes the instrument.This NMR spectrometer enhances research and education at all levels. It aids researchers studying the molecular determinants for the homodimerization of the receptor protein-tyrosine phosphatase J and the structure and topology of the protein caveolin-1 (as well as mutants of caveolin-1.) The spectrometer is also used for the determination of the structure of the RAMP1 transmembrane domain.

该奖项由主要研究仪器（MRI）和化学研究仪器项目支持。利哈伊大学的Kerney Glover教授和他的同事Bryan Berger和Damien Thevenin正在升级一台500兆赫核磁共振（NMR）光谱仪的控制台，并为光谱仪配备了冷冻探针。该光谱仪允许在各种领域的研究，如那些加速具有重要经济意义的化学反应，以及生物相关物种的研究。总的来说，核磁共振波谱是化学家研究分子结构的有力工具。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子间相互作用的变化。这些核磁共振研究的结果可能对合成有机/无机化学、材料化学和生物化学产生影响。该仪器是研究生和本科生通过独立学生研究和传统学术课程进行教学和研究的一个组成部分。该光谱仪用于支持利哈伊谷独立学院协会的学术机构成员，如拉斐特学院、库茨敦大学、雪松学院、德萨莱斯大学、摩拉维亚学院和穆伦伯格学院。这些机构的学生可以报名参加使用该仪器的高级实验班。这种核磁共振光谱仪增强了各级的研究和教育。它有助于研究人员研究受体蛋白-酪氨酸磷酸酶J的同二聚化的分子决定因素和蛋白caveolin-1的结构和拓扑结构（以及caveolin-1的突变体）。该光谱仪还用于测定RAMP1跨膜结构域的结构。