MRI: A Console Upgrade for a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer Equipped with a Liquid Nitrogen-Cooled Probe to Aid Multidisciplinary Research and Education

MRI：配备液氮冷却探头的 500 MHz 核磁共振 (NMR) 波谱仪控制台升级，以帮助多学科研究和教育

• 批准号: 1828399
• 负责人: David Mootoo
• 金额: $ 44.9万
• 依托单位: CUNY Hunter College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828399&HistoricalAwards=false
• 关键词: MRI; Console; Upgrade; 500; MHz

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor David Mootoo from CUNY Hunter College and colleagues Charles Drain and Matthew Devany have upgraded the console of a 500 MHz NMR spectrometer and have equipped the spectrometer with a liquid nitrogen cryoprobe. This upgraded spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as those that allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is useful to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes which permit use of small samples. The instrument is used for research and research training at this urban university and neighboring schools. Education and training in the science of NMR data interpretation is being accomplished in three overlapping ways: (1) via one-on-one interactions and workshops with the facility director; (2) in undergraduate courses and research experiences for undergraduates; and (3) through outreach activities that include demonstrations to high school and undergraduate students, for example, in the CUNY Math & Science Partnership Program. This award provides research infrastructure that will benefit the national health, and innovation in industry as well as technical workforce development. The upgraded NMR spectrometer with a cryoprobe enhances research and education at all levels. It especially impacts studies of small molecules, biopolymers and natural product discovery. The instrument is used to establish combinatorial libraries and to search for biomechanistic probes. In addition, the spectrometer is used in the preparation of scaffolds for nanotechnology materials, and functionalized lipids and dyes. The instrument also serves researchers investigating materials for fuel cells and batteries, and for quantitation of small molecules in agricultural products.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器项目和化学研究仪器项目支持。纽约州立大学亨特学院的大卫·穆托教授及其同事查尔斯·德雷恩和马修·德瓦尼升级了一台500 MHz核磁共振光谱仪的控制台，并为该光谱仪配备了一个液氮冷冻探头。这种升级的光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及那些可以研究生物相关物种的领域。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中的相互作用。对于正在进行前沿研究的化学家来说，使用最先进的核磁共振光谱仪是很有用的。与允许使用小样本的标准核磁共振探头相比，低温探头的灵敏度显著提高。该仪器用于这所城市大学和邻近学校的研究和研究性培训。核磁共振数据解释科学方面的教育和培训正在以三种重叠的方式完成：(1)通过与设施主任一对一的互动和讲习班；(2)本科生的本科课程和研究经验；(3)通过包括向高中生和本科生演示的外联活动，例如在纽约大学数学与科学伙伴计划中。该奖项提供了有益于国民健康的研究基础设施，以及工业创新和技术劳动力发展。升级后的带有低温探头的核磁共振光谱仪加强了各级的研究和教育。它尤其影响到对小分子、生物聚合物和天然产物发现的研究。该仪器用于建立组合库和寻找生物力学探针。此外，该光谱仪还用于制备纳米技术材料的支架，以及功能化的脂类和染料。该仪器还服务于研究燃料电池和电池材料以及农产品中小分子定量的研究人员。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Glycopolymer Microarrays with Sub‐Femtomolar Avidity for Glycan Binding Proteins Prepared by Grafted‐To/Grafted‐From Photopolymerizations

通过 Grafted–To/Grafted–From 光聚合制备的糖聚合物微阵列，对聚糖结合蛋白具有亚飞摩尔亲和力

• DOI: 10.1002/anie.202105729
• 发表时间: 2021
• 期刊: Angewandte Chemie International Edition
• 作者: Valles, Daniel J.;Zholdassov, Yerzhan S.;Korpanty, Joanna;Uddin, Samiha;Naeem, Yasir;Mootoo, David R.;Gianneschi, Nathan C.;Braunschweig, Adam B.
• 通讯作者: Braunschweig, Adam B.

DiPODS: A Reagent for Site-Specific Bioconjugation via the Irreversible Rebridging of Disulfide Linkages.

• DOI: 10.1021/acs.bioconjchem.0c00590
• 发表时间: 2020-12-16
• 期刊: Bioconjugate chemistry
• 影响因子: 4.7
• 作者: Khozeimeh Sarbisheh E;Dewaele-Le Roi G;Shannon WE;Tan S;Xu Y;Zeglis BM;Price EW
• 通讯作者: Price EW

Inverse electron demand Diels-Alder click chemistry for pretargeted PET imaging and radioimmunotherapy.

• DOI: 10.1038/s41596-021-00540-2
• 发表时间: 2021-07
• 期刊: Nature protocols
• 影响因子: 14.8
• 作者: Sarrett SM;Keinänen O;Dayts EJ;Dewaele-Le Roi G;Rodriguez C;Carnazza KE;Zeglis BM
• 通讯作者: Zeglis BM

Evaluation of [47Sc]Sc-HOPO toward radioscandium based radiopharmaceuticals

[47Sc]Sc-HOPO 对放射性钪基放射性药物的评价

• DOI: 10.1016/s0969-8051(21)00416-9
• 发表时间: 2021
• 期刊: Nuclear Medicine and Biology
• 影响因子: 3.1
• 作者: Phipps, Michael;Cingoranelli, Shelbie;Ferdous, Jannatul;Bhupathiraju, N. V.;Lapi, Suzanne;Lewis, Jason;Francesconi, Lynn;Deri, Melissa
• 通讯作者: Deri, Melissa