MRI: A Console Upgrade for a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer Equipped with a Liquid Nitrogen-Cooled Probe to Aid Multidisciplinary Research and Education

MRI：配备液氮冷却探头的 500 MHz 核磁共振 (NMR) 波谱仪控制台升级，以帮助多学科研究和教育

• 批准号: 1828399
• 负责人: David Mootoo
• 金额: $ 44.9万
• 依托单位: CUNY Hunter College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828399&HistoricalAwards=false
• 关键词: MRI; Console; Upgrade; 500; MHz

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor David Mootoo from CUNY Hunter College and colleagues Charles Drain and Matthew Devany have upgraded the console of a 500 MHz NMR spectrometer and have equipped the spectrometer with a liquid nitrogen cryoprobe. This upgraded spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as those that allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is useful to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes which permit use of small samples. The instrument is used for research and research training at this urban university and neighboring schools. Education and training in the science of NMR data interpretation is being accomplished in three overlapping ways: (1) via one-on-one interactions and workshops with the facility director; (2) in undergraduate courses and research experiences for undergraduates; and (3) through outreach activities that include demonstrations to high school and undergraduate students, for example, in the CUNY Math & Science Partnership Program. This award provides research infrastructure that will benefit the national health, and innovation in industry as well as technical workforce development. The upgraded NMR spectrometer with a cryoprobe enhances research and education at all levels. It especially impacts studies of small molecules, biopolymers and natural product discovery. The instrument is used to establish combinatorial libraries and to search for biomechanistic probes. In addition, the spectrometer is used in the preparation of scaffolds for nanotechnology materials, and functionalized lipids and dyes. The instrument also serves researchers investigating materials for fuel cells and batteries, and for quantitation of small molecules in agricultural products.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。来自纽约市立大学亨特学院的大卫穆图教授和同事查尔斯·德莱恩和马修·德瓦尼升级了500兆赫核磁共振光谱仪的控制台，并为光谱仪配备了液氮冷冻探针。这款升级后的光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及研究生物相关物种。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固态分子之间的相互作用。使用最先进的NMR光谱仪对进行前沿研究的化学家非常有用。相对于允许使用小样品的标准NMR探针，低温探针提供了灵敏度的显著增加。该仪器用于该城市大学和邻近学校的研究和研究培训。核磁共振数据解释科学的教育和培训正在通过三种重叠的方式完成：（1）通过与设施主任的一对一互动和研讨会;（2）本科生的本科课程和研究经验;（3）通过外展活动，包括向高中和本科生进行演示，例如，在纽约市立大学数学科学合作计划中。& 该奖项提供的研究基础设施将有利于国家健康，工业创新以及技术劳动力发展。配备冷冻探针的升级核磁共振光谱仪加强了各级的研究和教育。它特别影响小分子，生物聚合物和天然产物发现的研究。该仪器用于建立组合库和搜索生物力学探针。此外，该光谱仪还用于纳米技术材料支架的制备，以及功能化脂质和染料。该仪器还可用于研究燃料电池和电池材料的研究人员，以及定量分析农产品中的小分子。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Glycopolymer Microarrays with Sub‐Femtomolar Avidity for Glycan Binding Proteins Prepared by Grafted‐To/Grafted‐From Photopolymerizations

通过 Grafted–To/Grafted–From 光聚合制备的糖聚合物微阵列，对聚糖结合蛋白具有亚飞摩尔亲和力

• DOI: 10.1002/anie.202105729
• 发表时间: 2021
• 期刊: Angewandte Chemie International Edition
• 作者: Valles, Daniel J.;Zholdassov, Yerzhan S.;Korpanty, Joanna;Uddin, Samiha;Naeem, Yasir;Mootoo, David R.;Gianneschi, Nathan C.;Braunschweig, Adam B.
• 通讯作者: Braunschweig, Adam B.

DiPODS: A Reagent for Site-Specific Bioconjugation via the Irreversible Rebridging of Disulfide Linkages.

• DOI: 10.1021/acs.bioconjchem.0c00590
• 发表时间: 2020-12-16
• 期刊: Bioconjugate chemistry
• 影响因子: 4.7
• 作者: Khozeimeh Sarbisheh E;Dewaele-Le Roi G;Shannon WE;Tan S;Xu Y;Zeglis BM;Price EW
• 通讯作者: Price EW

Inverse electron demand Diels-Alder click chemistry for pretargeted PET imaging and radioimmunotherapy.

• DOI: 10.1038/s41596-021-00540-2
• 发表时间: 2021-07
• 期刊: Nature protocols
• 影响因子: 14.8
• 作者: Sarrett SM;Keinänen O;Dayts EJ;Dewaele-Le Roi G;Rodriguez C;Carnazza KE;Zeglis BM
• 通讯作者: Zeglis BM

Evaluation of [47Sc]Sc-HOPO toward radioscandium based radiopharmaceuticals

[47Sc]Sc-HOPO 对放射性钪基放射性药物的评价

• DOI: 10.1016/s0969-8051(21)00416-9
• 发表时间: 2021
• 期刊: Nuclear Medicine and Biology
• 影响因子: 3.1
• 作者: Phipps, Michael;Cingoranelli, Shelbie;Ferdous, Jannatul;Bhupathiraju, N. V.;Lapi, Suzanne;Lewis, Jason;Francesconi, Lynn;Deri, Melissa
• 通讯作者: Deri, Melissa