MRI: A Console Upgrade for a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer Equipped with a Liquid Nitrogen-Cooled Probe to Aid Multidisciplinary Research and Education

该奖项由主要研究仪器和化学研究仪器项目支持。纽约市立大学亨特学院的David Mootoo教授和他的同事Charles Drain和Matthew Devany已经升级了一台500兆赫核磁共振光谱仪的控制台，并为光谱仪配备了液氮冷冻探针。这种升级的光谱仪允许在各种领域进行研究，例如那些加速具有重要经济意义的化学反应的领域，以及那些允许研究生物相关物种的领域。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间的相互作用。获得最先进的核磁共振光谱仪对进行前沿研究的化学家是有用的。低温探头相对于允许使用小样本的标准核磁共振探头提供了显著的灵敏度增加。该仪器用于这所城市大学和邻近学校的研究和研究培训。核磁共振数据解释科学的教育和培训是通过三种重叠的方式完成的：(1)通过一对一的互动和与设施主任的研讨会；(2)本科生的本科课程和研究经历；(3)通过外联活动，包括向高中生和本科生示范，例如，在纽约市立大学数学与科学合作计划中。该奖项提供的研究基础设施将有利于国家卫生、工业创新和技术劳动力发展。带冷冻探针的升级核磁共振波谱仪增强了各级的研究和教育。它尤其影响小分子、生物聚合物和天然产物发现的研究。该仪器用于建立组合文库和搜索生物力学探针。此外，该光谱仪还用于纳米材料支架的制备，以及功能化脂质和染料的制备。该仪器还为研究燃料电池和电池材料的研究人员提供服务，并用于农产品中小分子的定量。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor David Mootoo from CUNY Hunter College and colleagues Charles Drain and Matthew Devany have upgraded the console of a 500 MHz NMR spectrometer and have equipped the spectrometer with a liquid nitrogen cryoprobe. This upgraded spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as those that allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is useful to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes which permit use of small samples. The instrument is used for research and research training at this urban university and neighboring schools. Education and training in the science of NMR data interpretation is being accomplished in three overlapping ways: (1) via one-on-one interactions and workshops with the facility director; (2) in undergraduate courses and research experiences for undergraduates; and (3) through outreach activities that include demonstrations to high school and undergraduate students, for example, in the CUNY Math & Science Partnership Program. This award provides research infrastructure that will benefit the national health, and innovation in industry as well as technical workforce development. The upgraded NMR spectrometer with a cryoprobe enhances research and education at all levels. It especially impacts studies of small molecules, biopolymers and natural product discovery. The instrument is used to establish combinatorial libraries and to search for biomechanistic probes. In addition, the spectrometer is used in the preparation of scaffolds for nanotechnology materials, and functionalized lipids and dyes. The instrument also serves researchers investigating materials for fuel cells and batteries, and for quantitation of small molecules in agricultural products.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.