MRI: A Console Upgrade for a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer Equipped with a Liquid Nitrogen-Cooled Probe to Aid Multidisciplinary Research and Education

MRI：配备液氮冷却探头的 500 MHz 核磁共振 (NMR) 波谱仪控制台升级，以帮助多学科研究和教育

• 批准号: 1828399
• 负责人: David Mootoo
• 金额: $ 44.9万
• 依托单位: CUNY Hunter College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828399&HistoricalAwards=false
• 关键词: MRI; Console; Upgrade; 500; MHz

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor David Mootoo from CUNY Hunter College and colleagues Charles Drain and Matthew Devany have upgraded the console of a 500 MHz NMR spectrometer and have equipped the spectrometer with a liquid nitrogen cryoprobe. This upgraded spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as those that allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is useful to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes which permit use of small samples. The instrument is used for research and research training at this urban university and neighboring schools. Education and training in the science of NMR data interpretation is being accomplished in three overlapping ways: (1) via one-on-one interactions and workshops with the facility director; (2) in undergraduate courses and research experiences for undergraduates; and (3) through outreach activities that include demonstrations to high school and undergraduate students, for example, in the CUNY Math & Science Partnership Program. This award provides research infrastructure that will benefit the national health, and innovation in industry as well as technical workforce development. The upgraded NMR spectrometer with a cryoprobe enhances research and education at all levels. It especially impacts studies of small molecules, biopolymers and natural product discovery. The instrument is used to establish combinatorial libraries and to search for biomechanistic probes. In addition, the spectrometer is used in the preparation of scaffolds for nanotechnology materials, and functionalized lipids and dyes. The instrument also serves researchers investigating materials for fuel cells and batteries, and for quantitation of small molecules in agricultural products.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项得到了主要的研究工具和化学研究工具计划的支持。来自CUNY Hunter College及其同事Charles Drain和Matthew Devany的David Mootoo教授升级了500 MHz NMR光谱仪的控制台，并为光谱仪配备了液态氮气冰probe。该升级的光谱仪允许在各种领域进行研究，例如加速具有重要经济意义的化学反应的领域，以及允许研究生物学相关物种的化学反应。通常，核磁共振（NMR）光谱是化学家可用于阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子或固态中分子之间的相互作用。访问最先进的NMR光谱仪对进行边境研究的化学家很有用。低温探针相对于允许使用小样品的标准NMR探针提供了敏感性的显着提高。该工具用于该城市大学和邻近学校的研究和研究培训。 NMR数据解释科学的教育和培训正在以三种重叠的方式完成：（1）通过与设施主管进行一对一的互动和研讨会； （2）在本科生的本科课程和研究经验中； （3）通过包括向高中和本科生示威的外展活动，例如在CUNY数学与科学合作伙伴计划中。 该奖项提供了研究基础设施，该基础设施将使国家健康和工业劳动力发展的创新有益。带有冷冻探针的升级的NMR光谱仪可以在各个层面上增强研究和教育。它特别影响了小分子，生物聚合物和自然产物发现的研究。该仪器用于建立组合文库并搜索生物力学探针。此外，光谱仪用于制备纳米技术材料的支架，以及功能化的脂质和染料。该仪器还为研究人员提供了研究燃料电池和电池的材料，并为农业产品中的小分子定量。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的智力优点和更广泛影响的评估评估标准的评估值得支持的。

项目成果

Glycopolymer Microarrays with Sub‐Femtomolar Avidity for Glycan Binding Proteins Prepared by Grafted‐To/Grafted‐From Photopolymerizations

通过 Grafted–To/Grafted–From 光聚合制备的糖聚合物微阵列，对聚糖结合蛋白具有亚飞摩尔亲和力

• DOI: 10.1002/anie.202105729
• 发表时间: 2021
• 期刊: Angewandte Chemie International Edition
• 作者: Valles, Daniel J.;Zholdassov, Yerzhan S.;Korpanty, Joanna;Uddin, Samiha;Naeem, Yasir;Mootoo, David R.;Gianneschi, Nathan C.;Braunschweig, Adam B.
• 通讯作者: Braunschweig, Adam B.

DiPODS: A Reagent for Site-Specific Bioconjugation via the Irreversible Rebridging of Disulfide Linkages.

• DOI: 10.1021/acs.bioconjchem.0c00590
• 发表时间: 2020-12-16
• 期刊: Bioconjugate chemistry
• 影响因子: 4.7
• 作者: Khozeimeh Sarbisheh E;Dewaele-Le Roi G;Shannon WE;Tan S;Xu Y;Zeglis BM;Price EW
• 通讯作者: Price EW

Evaluation of [47Sc]Sc-HOPO toward radioscandium based radiopharmaceuticals

[47Sc]Sc-HOPO 对放射性钪基放射性药物的评价

• DOI: 10.1016/s0969-8051(21)00416-9
• 发表时间: 2021
• 期刊: Nuclear Medicine and Biology
• 影响因子: 3.1
• 作者: Phipps, Michael;Cingoranelli, Shelbie;Ferdous, Jannatul;Bhupathiraju, N. V.;Lapi, Suzanne;Lewis, Jason;Francesconi, Lynn;Deri, Melissa
• 通讯作者: Deri, Melissa

Inverse electron demand Diels-Alder click chemistry for pretargeted PET imaging and radioimmunotherapy.

• DOI: 10.1038/s41596-021-00540-2
• 发表时间: 2021-07
• 期刊: Nature protocols
• 影响因子: 14.8
• 作者: Sarrett SM;Keinänen O;Dayts EJ;Dewaele-Le Roi G;Rodriguez C;Carnazza KE;Zeglis BM
• 通讯作者: Zeglis BM