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MRI: Acquisition of a High Resolution Mass Spectrometer/UPLC System

MRI：购置高分辨率质谱仪/UPLC 系统

基本信息

批准号：
1726738
负责人：
Charles Greenlief
金额：
$ 47.64万
依托单位：
University of Missouri-Columbia
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2019-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1726738&HistoricalAwards=false
关键词：
MRI Acquisition Resolution Mass Spectrometer

项目摘要

An award is made to the University of Missouri to acquire a high resolution mass spectrometer coupled with an ultra-high performance liquid chromatography system. The instrument will be used to help further our understanding of proteins in a variety of plants including soybean, corn, and elderberry. It will also be used to examine fertility loss in animals at the protein level in support of agriculture. The University is collaborating with Evans Analytical Group (EAG) Columbia (a GLP and CGMP-compliant product development and analytical testing services company based in Columbia, MO) in a continuing industry internship program for undergraduates. Each spring undergraduate interns participate in an intensive four-week training course. This in-depth course offers a select set of high-caliber undergraduates an opportunity to develop analytical skills, with an emphasis on separations and mass spectrometry, in preparation for being employed by EAG Columbia as summer interns. Biochemistry and Chemistry undergraduate students will also use the instrument in advanced lab classes to further their understanding of modern instrumentation.Mass spectrometry is an essential method for determining the structure of large biomolecules such as proteins. It is also possible to use this method to examine modifications to proteins. The acquisition of the high resolution mass spectrometer will allow the investigators of the project to perform quantitative protein analyses, develop new analysis capabilities, and improve instrument access at the University of Missouri. The major users of the instrument have active research programs examining protein changes in a variety of plants and animals.

授予密苏里州大学一项合同，以获得一个与超高效液相色谱系统相结合的高分辨率质谱仪。该仪器将用于帮助我们进一步了解各种植物中的蛋白质，包括大豆，玉米和接骨木。它还将用于在蛋白质水平上检查动物的生育力损失，以支持农业。该大学正在与埃文斯分析集团（EAG）哥伦比亚（一家符合GLP和cGMP的产品开发和分析测试服务公司，总部设在密苏里州哥伦比亚）合作，为本科生提供持续的行业实习计划。每年春季，本科实习生都要参加为期四周的强化培训课程。这个深入的课程提供了一组高素质的本科生有机会发展分析技能，重点是分离和质谱，准备被EAG哥伦比亚作为暑期实习生雇用。生物化学和化学本科生也将使用该仪器在先进的实验室课程，以进一步他们对现代仪器的理解。质谱是确定大生物分子，如蛋白质的结构的基本方法。也可以使用这种方法来检查蛋白质的修饰。获得高分辨率质谱仪将使该项目的研究人员能够进行定量蛋白质分析，开发新的分析能力，并改善密苏里州大学的仪器访问。该仪器的主要用户有积极的研究计划，检查各种植物和动物的蛋白质变化。