US-Brazil Workshop on Biosensors: Bioanalytics to Device Integration; November 8-10, 2017; Federal University of ABC, Santo Andre, Sao Paulo, Brazil

美国-巴西生物传感器研讨会将汇集来自工程、物理、化学和生物学多学科领域的美国和巴西领先科学家和研究人员。该研讨会由国际科学与工程办公室共同资助，将于2017年11月8日至10日在位于巴西圣保罗郊区的圣安德烈ABC联邦大学举行。该研讨会将汇集大约100名与会者，其中包括25名演讲者（来自美国和巴西）和大约70名来自巴西的研究生和科学家。诸如内脏利什曼病、疟疾和肺结核等传染病是南美洲、非洲和亚洲一些地区的地方病。尽管在几种传染病的基于微/纳米技术的诊断方面取得了重大突破，但许多病原体缺乏疫苗或药物。在这种情况下，必须及早发现，以防止患者死亡。研讨会的目标是通过整合生物材料研究和半导体技术，为开发用于病媒传播疾病的低成本敏感探测器提供路线图。拟议的讲习班使具有互补技能的研究人员与从事生物分析、生物相容性蛋白质基材料和其他纳米材料领域工作的巴西科学家以及专门从事半导体技术、光学、磁和电检测以及涉及可扩展集成电路的过程的美国科学家一起参与，从而对开发和整合将对全球卫生产生重大影响的低成本诊断工具采取整体方法。预计美国和巴西科学家之间将开展新的合作，为培养生物电子学、传感和诊断学方面的学生铺平道路。这种合作努力将为两国之间的学生交流项目提供机会，并为美国和巴西的研究生和本科教育开发新的课程，以跨学科的方式瞄准低成本的生物传感器。本次研讨会将为研究人员提供一个独特的平台，讨论生物传感器新材料、分析工具和使用互补金属氧化物半导体和其他可扩展技术的生物传感电路集成领域的最新创新、趋势和面临的众多挑战。尽管聚合酶链反应和酶联免疫吸附试验已成为临床诊断的常用工具，但它们对于特定疾病流行地区的大规模筛查并不理想。半导体技术与生物学的结合是开发快速低成本传感器的必要条件。将半导体技术与生物界面相结合有几个挑战。研讨会将聚焦于新材料的开发，集成电解门控晶体管，以及集成不同转导机制的微流体阵列的无缝集成，包括电，磁和光学集成，以解决这些挑战。研讨会的多学科方法不仅在材料开发方面推进了基础科学和技术，并提供了对物理现象的新见解；它有望对低成本便携式传感器的发展产生巨大影响，这将改变快速检测的游戏规则，并可能彻底改变检测机制，临床诊断，并改善几种媒介传播疾病的治疗处理。

The US-Brazil workshop on biosensors will bring together leading US and Brazilian scientists and researchers from multidisciplinary areas of engineering, physics, chemistry, and biology. The workshop, co-funded by the Office of International Science and Engineering, will take place November 8-10, 2017, at the Federal University of ABC, Santo Andre, which is located in the outskirts of Sao Paulo, Brazil. The workshop will bring together roughly 100 participants including 25 speakers (from US and Brazil) and approximately 70 graduate students and scientists from Brazil. Infectious diseases such as visceral Leishmaniasis, malaria, and tuberculosis are endemic to several parts of South America, Africa, and Asia. Although there have been major breakthroughs in micro/nanotechnology based diagnosis for several infectious diseases, many pathogens lack vaccines or drugs. In such cases, early detection is imperative to prevent patient mortality. The goal of the workshop is to provide a roadmap for the development of low-cost sensitive detectors for vector-borne diseases by integrating biomaterials research and semiconductor technology. The proposed workshop enables a holistic approach towards the development and integration of low-cost diagnostic tools that will have a great impact on global health by involving researchers with complementary skill sets with Brazilian scientists working in areas of bioanalytics, biocompatible protein-based and other nano-materials, and US scientists specializing in semiconductor technology, optical, magnetic and electrical detection, and processes involving scalable integration of circuits. New collaborative efforts between scientists from the US and Brazil are envisaged, paving the way for training students in bioelectronics, sensing, and diagnostics. Such collaborative efforts will open up opportunities for student exchange programs between the two countries, and the development of new curricula for graduate and undergraduate education both in the US and Brazil targeting low-cost biosensors in a cross-disciplinary fashion.The proposed workshop will provide a unique platform for researchers to discuss the recent innovations, trends, and multitude of challenges encountered in the areas of new materials for biosensors, analytical tools, and integration of biosensing circuits using complementary metal-oxide-semiconductor and other scalable technology. Although polymerase chain reaction and enzyme-linked immunosorbent assay have become common tools for clinical diagnosis, they are not ideal for mass screening in endemic areas of a particular disease. The integration of semiconductor technology with biology is essential for the development of fast low-cost sensors. There are several challenges in integrating semiconductor technology with bio-interfaces. The workshop will address these challenges by focusing on new materials development, integrating electrolytic gated transistors, and seamless integration of microfluidic arrays incorporating different transducing mechanisms including electrical, magnetic and optical integrability. The multidisciplinary approach of the workshop not only advances basic science and technology in terms of materials development and providing new insights into physical phenomena; it promises to have a huge impact in the development of low-cost portable sensors which will be a game-changer for fast detection, and could revolutionize the mechanism of detection, clinical diagnosis, and improvement of therapeutic handling of several vector-borne diseases.