Phase I IUCRC at Purdue University: Center for Bioanalytic Metrology (CBM)

普渡大学 IUCCRC 第一阶段：生物分析计量中心 (CBM)

• 批准号: 1916691
• 负责人: Garth Simpson
• 金额: $ 75.1万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1916691&HistoricalAwards=false
• 关键词: Phase; IUCRC; Purdue; University; Center

The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems. Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas generated through collaboration between academia and industry and the delivery of practical pre-competitive knowledge that can drive technology development. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff.The CBM is devoted to advancing bioanalytical measurement science and applying these advances to address challenges in small molecule pharmaceuticals or agrochemicals development and delivery, in the analysis of foods, in biologically derived petrochemicals and/or biofuels, and in biological materials analysis. The CBM serves the industrial partners with research solutions in: (a) ultrahigh sensitivity assays for trace-level biomarkers and impurities; (b) discrimination between large biomolecules and their multi-molecule complexes; (c) reduced volume/materials analysis and experimentation at high throughput and productivity; (d) analysis of rare/extremely dilute cells/molecules/exosomes, etc.; (e) massively parallel approaches to chemical cytometry, genetic profiling, and panel screening; (f) online and near-line in situ measurements; (g) point-of-use analysis, companion diagnostics, and inexpensive testing in the field; (h) AI-driven instrumentation, feedback optimization, and "driverless" instruments; and (i) enhanced imaging of cells, organisms, and chemical processes. Purdue University brings specific strength in chemical imaging, mass spectrometry, chromatography, particulate analysis, instrumentation design and development, "big data" analytics, and dimension reduction / machine learning for chemical decision-making.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物分析计量中心（CBM）是圣母大学、印第安纳州大学和普渡大学之间的合作伙伴关系，通过与行业合作解决测量科学和技术领域当前、新兴和行业相关的挑战，提高美国的竞争力。该中心有两个主要目标：（1）提供一流的分子测量工具和专业知识，使强大的新的竞争前技术和能力的发展跨越制药，生物技术，食品/营养/农业，能源和分析仪器部门;和（2）作为一个试验场的新仪器应用到尖端的化学和生物化学问题。测量科学和相关仪器是美国经济的关键贡献者，从药物发现到材料制造，都在取得进步。通过将这些高科技领域的公司与主要的分析仪器制造商聚集在一起，CBM弥合了学术界和工业界合作产生的新想法的初步演示与能够推动技术发展的实用竞争前知识的交付之间的差距。同样重要的是，CBM为美国工业提供了令人信服的机会，通过获得中心培训的学生的多样性和现有员工继续教育的机会来振兴人力资源。CBM致力于推进生物分析测量科学，并将这些进步应用于解决小分子药物或农用化学品开发和交付，食品分析，生物衍生的石油化学品和/或生物燃料，以及生物材料分析。CBM为工业合作伙伴提供以下研究解决方案：（a）痕量生物标志物和杂质的微生物灵敏度测定;（B）大生物分子及其多分子复合物之间的区分;（c）以高通量和生产率进行减少体积/材料的分析和实验;（d）稀有/极稀细胞/分子/外来体等的分析;（e）生物标志物和杂质的分析。(e)大规模并行的化学细胞术，遗传分析和面板筛选方法;（f）在线和近线原位测量;（g）现场使用点分析，伴随诊断和廉价测试;（h）人工智能驱动的仪器，反馈优化和“无人驾驶”仪器;以及（i）增强细胞，生物体和化学过程的成像。普渡大学在化学成像、质谱、色谱、颗粒分析、仪器设计和开发、“大数据”分析以及用于化学决策的降维/机器学习方面具有特殊优势。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Incoherent Nonreciprocal Absorbance Circular Dichroism of Uniaxial Assemblies

• DOI: 10.1021/acs.jpcb.3c03104
• 发表时间: 2023-09-18
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY B
• 影响因子: 3.3
• 作者: Turner，Gwendylan A.;Hwang，Yechan;Simpson，Garth J.
• 通讯作者: Simpson，Garth J.

Parts-per-Million Detection of Trace Crystal Forms Using AF-PTIR Microscopy

• DOI: 10.1021/acs.analchem.2c02358
• 发表时间: 2022-09-13
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Razumtcev，Aleksandr;Li，Minghe;Simpson，Garth J.
• 通讯作者: Simpson，Garth J.

Periodic Photobleaching with Structured Illumination for Diffusion Imaging

• DOI: 10.1021/acs.analchem.2c02950
• 发表时间: 2023-01-19
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Cao，Ziyi;Harmon，Dustin M.;Simpson，Garth J.
• 通讯作者: Simpson，Garth J.

Pulse-Picking Multimodal Nonlinear Optical Microscopy

• DOI: 10.1021/acs.analchem.2c03284
• 发表时间: 2022-10-25
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Clark, Matthew G.;Gonzalez, Gil A.;Zhang, Chi
• 通讯作者: Zhang, Chi

Fast Diffusion Characterization by Multiphoton Excited Fluorescence Recovery while Photobleaching

• DOI: 10.1021/acs.analchem.3c02638
• 发表时间: 2023-09-12
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Li，Minghe;Razumtcev，Aleksandr;Simpson，Garth J.
• 通讯作者: Simpson，Garth J.