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The ecology of oxidative stress in bats

蝙蝠氧化应激的生态学

基本信息

批准号：
232331009
负责人：
Privatdozent Dr. Christian C. Voigt
金额：
--
依托单位：
Leibniz-Institut für Zoo- und Wildtierforschung (IZW)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2013-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/232331009?language=en
关键词：
ecology oxidative stress bats

项目摘要

Oxidative stress, an imbalance between pro-oxidants and antioxidants causing molecular damage to cells, is regarded as the main cause of ageing. As pro-oxidant production increases with mass-specific metabolic rates, animals with higher rates should exhibit shorter life spans. However, two vertebrate groups, birds and bats, are an exception to this general rule. Both taxa have low pro-oxidant production rates and high antioxidant levels in blood plasma, a pattern that was suggested to relate to their relatively longer life spans. While antioxidant levels have been found to be influenced mainly by diet, pro-oxidants may increase with immune responses and high parasite loads. The goal of this study is to elucidate the effect of diet, parasite load and immune status on the oxidative stress of free-ranging mammals. I would like to use bats as model organisms for this purpose, because they are ideal for comparative studies considering their species richness and their ecological diversity. By measuring pro-oxidant and antioxidant levels in blood plasma of various Neotropical and European bat species, I hope to shed light on the factors influencing the oxidative stress of free-ranging mammals, and on the yet unanswered question whether a mild oxidative stress is responsible for the longevity of bats.

氧化应激，即促氧化剂和抗氧化剂之间的不平衡，对细胞造成分子损伤，被认为是衰老的主要原因。由于促氧化剂的产生随着质量特定代谢率的增加而增加，因此具有较高代谢率的动物应该表现出较短的寿命。然而，鸟类和蝙蝠这两个脊椎动物群体是这一一般规则的例外。这两个类群的血浆中促氧化剂生成率较低，而抗氧化剂水平较高，这种模式被认为与其相对较长的寿命有关。虽然已发现抗氧化剂水平主要受饮食影响，但促氧化剂可能会随着免疫反应和高寄生虫负荷而增加。本研究的目的是阐明饮食、寄生虫负荷和免疫状态对自由放养哺乳动物氧化应激的影响。为此，我想使用蝙蝠作为模式生物，因为考虑到它们的物种丰富度和生态多样性，它们是比较研究的理想选择。通过测量各种新热带和欧洲蝙蝠的血浆中促氧化剂和抗氧化剂的水平，我希望能够阐明影响自由放养哺乳动物氧化应激的因素，以及轻度氧化应激是否与蝙蝠的长寿有关的尚未解答的问题。