I-Corps: Natural Compounds for Wound Healing

I-Corps项目更广泛的影响/商业潜力是提供一种基于两种天然化合物的可负担且有效的慢性伤口治疗方法。在美国，慢性伤口影响着数百万人，占整体医疗保健费用的很大一部分。然而，由于皮肤的多层结构和细胞外基质中存在不同类型的细胞，因此皮肤的再生仍然是一个巨大的挑战。这种复杂性需要使用具有抗氧化、抗炎、抗微生物、促血管生成和促愈合特性的多功能药物。与传统方法相比，所提出的治疗策略的潜在优势包括降低成本、减少副作用、降低感染风险和提高患者依从性。I-Corps项目的核心技术是一种慢性伤口愈合产品，该产品由两种从植物源中分离出来的酚类化合物组成，具有抗炎、促血管生成和促再生活性。慢性伤口愈合是一个复杂的生理过程，由相互依存的生化和细胞事件精心策划的级联控制。提出的创新利用天然化合物的多靶向能力来调节慢性伤口中炎症、上皮化和血管形成之间的相互作用。该团队将开发一种基于酚类天然化合物专有配方的最小可行产品，以加速成纤维细胞和角质形成细胞的迁移，增强血管形成，并调节巨噬细胞反应。这个项目的范围并不一定局限于伤口修复领域。揭示调节免疫调节信号级联的细胞和分子作用模式是药物发现的重要一步，具有广泛的潜在应用。

The broader impact/commercial potential of this I-Corps project is providing affordable and effective method to treat chronic wounds based on the use of two natural compounds. Chronic wounds affect millions of people in US and account for a significant fraction of overall health care costs. Nevertheless, the regeneration of skin remains a huge challenge due to its multilayered structure and the presence of different cell types organized within the extracellular matrix. This complexity necessitates the use of multi-functional drugs with antioxidant, anti-inflammatory, anti-microbial, pro-angiogenesis and pro-healing properties. The potential advantages of the proposed treatment strategy over conventional approaches include reduced cost, decreased side-effects, lower risk of infection, and increased patient compliance.This I-Corps project core technology is a chronic wound healing product composed of two phenolic compounds isolated from a botanical source to yield an active source of anti-inflammatory, pro-angiogenic and pro-regeneration activities. Chronic wound healing is a complex physiological process controlled by a well-orchestrated cascade of interdependent biochemical and cellular events. The proposed innovation harnesses the multi-targeting ability of natural compounds to modulate the crosstalk between inflammation, epithelialization and vascular formation in chronic wounds. The team will potentially develop a minimum viable product based on a proprietary formulation of phenolic natural compounds to accelerate fibroblast and keratinocytes migration, enhance blood vessel formation, and modulate macrophage response. The scope of this project is not necessarily confined to the field of wound repair. Unraveling the cellular and molecular modes of action that regulate immunomodulatory signaling cascades is an important step in drug discovery with a wide array of potential applications.