MRI: Acquisition of a 400 MHz NMR Spectrometer at Fairfield University

该奖项由主要研究仪器项目和化学研究仪器项目支持。费尔菲尔德大学的John Miecznikowski教授和他的同事Matthew Kubasik、Aaron Van Dyke和Jillian Smith-Carpenter获得了一台配备自动采样器的400 MHz核磁共振光谱仪。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及允许研究与生物相关的物种。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该仪器对该机构和附近爱奥纳学院的学生产生了积极影响。研究团队正在与费尔菲尔德大学的向上绑定计划合作，为来自布里奇波特、康涅狄格州学校系统的9-12年级学生和大多数学生举办一系列为期一天的科学仪器研讨会。这些学生中的许多人认为自己是少数族裔和低收入者。他们还与费尔菲尔德大学面向来自布里奇波特学校的当地高中生的年度拓宽科学教育途径(基地)夏令营合作，这些学生与教师导师一起参与实践研究体验。该提案旨在加强各级的研究和教育。它特别有助于开发基于锌(II)钳形络合物的水溶性羰基还原预催化剂和螺旋肽构象动力学的研究。该光谱仪在表征捕获-标签-释放探针的合成产品以标记内源性酶，如组蛋白脱乙酰基酶，以及那些完全合成1，2-二硫杂环戊烷功能化自组装肽的产品方面至关重要。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor John Miecznikowski from Fairfield University and colleagues Matthew Kubasik, Aaron Van Dyke and Jillian Smith-Carpenter have acquired a 400 MHz NMR spectrometer equipped with an automatic sampler. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The instrument positively impacts students at this institution and at nearby Iona College. The research team is partnering with the Upward Bound Program at Fairfield University by hosting a series of one-day scientific instrumentation workshops for 9-12th graders from the Bridgeport, CT school system and most of the students. Many of these students identify themselves as minority and low-income. They also partner with the annual Broadening Access to Science Education (BASE) Camp at Fairfield University directed to local high school students from Bridgeport schools who participate in hands-on research experiences with faculty mentors. The proposal is aimed at enhancing research and education at all levels. It especially aids the development of water-soluble carbonyl reduction precatalysts based on zinc(II) pincer complexes and studies of helical peptide conformational dynamics. The spectrometer is essential in characterizing synthetic products of capture-tag-release probes to label endogenous enzymes, such as histone deacetylases, and those prepared thorough synthesis of 1,2-dithiolane functionalized self-assembling peptides.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.