CAREER: Determine the Roles of Material Heterogeneity and Thickness Variability on the Stability of Thin Membranes

职业：确定材料异质性和厚度变异性对薄膜稳定性的作用

• 批准号: 1847062
• 负责人: Shuodao Wang
• 金额: $ 50万
• 依托单位: Oklahoma State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1847062&HistoricalAwards=false
• 关键词: CAREER; Determine; Roles; Material; Heterogeneity

This Faculty Early Career Development Program (CAREER) award will support integrated research and educational efforts to generate new knowledge of how material and thickness non-uniformity (also referred to as heterogeneity) in thin, bio-compatible materials and bio-tissues affect their mechanical behaviors under various deformation conditions. Examples of such materials include ultra-thin wearable bio-sensors, the eardrum membrane, and the heart valves. The award supports fundamental research that will enable a currently unavailable, non-destructive material characterization protocol for obtaining the material property maps, which will allow the deformation and stability of these materials to be better understood. The innovative approach in this project is expected to promote scientific advancement in new mechanics knowledge that is important for a wide range of healthcare and biomedical applications, thereby impacting the national health and economy. The project will provide opportunities to train graduate and undergraduate students in the important interdisciplinary areas of mechanics, materials science, and biomedical devices. The educational outreach activities are designed to engage young children and under-represented minorities in STEM education, with the goal of enlarging the STEM talent pool for the nation.Many important natural and synthesized heterogeneous thin membranes wrinkle under very small loads. Stability of thin structures has long been a canonical problem in the mechanics community. Yet to date, huge discrepancies in buckling loads between theories and experiments are still usually accounted for by empirical corrections. There is a clear lag in understanding for predicting the buckling loads of thin heterogeneous membranes. The objective of this CAREER project is to test the hypothesis that a higher degree of heterogeneity in thin membranes reduces the critical buckling loads. The research approach is to experimentally measure and compare the buckling loads of a set of thin membranes of various degrees of heterogeneity ranging from highly heterogeneous to homogeneous. Fluorescence stereo microscopy and inverse finite element analysis will be combined to extract the material property distributions and thickness variability, and then a theory-guided numerical model will be developed to identify a quantitative degree of heterogeneity and elucidate how it is related to reduced buckling loads.This project is jointly funded by the Civil, Mechanical, and Manufacturing Innovation program (CMMI), and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该学院早期职业发展计划（CAREER）奖将支持综合研究和教育工作，以产生薄的生物相容性材料和生物组织中的材料和厚度不均匀性（也称为异质性）如何影响其在各种变形条件下的机械行为的新知识。 这种材料的例子包括超薄可穿戴生物传感器、鼓膜和心脏瓣膜。 该奖项支持基础研究，这将使目前不可用的，非破坏性的材料表征协议，以获得材料属性图，这将使这些材料的变形和稳定性得到更好的理解。该项目的创新方法有望促进新力学知识的科学进步，这对广泛的医疗保健和生物医学应用至关重要，从而影响国民健康和经济。 该项目将提供机会，培养研究生和本科生在力学，材料科学和生物医学设备的重要跨学科领域。 教育推广活动旨在让幼儿和代表性不足的少数民族参与STEM教育，目标是扩大国家的STEM人才库。许多重要的天然和合成异质薄膜在非常小的负载下就会起皱。薄壁结构的稳定性问题一直是力学界的经典问题。然而，迄今为止，理论和实验之间的屈曲载荷的巨大差异仍然通常由经验修正。对于非均匀薄膜的屈曲载荷的预测，人们的认识明显滞后。这个CAREER项目的目的是检验这样一个假设，即薄膜的高度不均匀性降低了临界屈曲载荷。研究方法是实验测量和比较的屈曲载荷的各种程度的异质性，从高度异质性均匀的一组薄膜。荧光体视显微镜和逆有限元分析相结合，提取材料的属性分布和厚度变化，然后将开发一个理论指导的数值模型，以确定定量的异质性程度，并阐明它是如何与减少屈曲载荷。该项目由土木，机械和制造创新计划（CMMI）联合资助，该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

An investigation of how specimen dimensions affect biaxial mechanical characterizations with CellScale BioTester and constitutive modeling of porcine tricuspid valve leaflets

使用 CellScale BioTester 和猪三尖瓣小叶的本构模型研究样本尺寸如何影响双轴机械特性

• DOI: 10.1016/j.jbiomech.2023.111829
• 发表时间: 2023
• 期刊: Journal of Biomechanics
• 影响因子: 2.4
• 作者: Laurence, Devin W.;Wang, Shuodao;Xiao, Rui;Qian, Jin;Mir, Arshid;Burkhart, Harold M.;Holzapfel, Gerhard A.;Lee, Chung-Hao
• 通讯作者: Lee, Chung-Hao

Machine learning based inverse modeling of full-field strain distribution for mechanical characterization of a linear elastic and heterogeneous membrane

基于机器学习的全场应变分布逆建模，用于线性弹性和异质膜的机械表征

• DOI: 10.1016/j.mechmat.2021.104134
• 发表时间: 2022
• 期刊: Mechanics of Materials
• 影响因子: 3.9
• 作者: Zhang, Yuan;Guo, Lin;Brousse, Clement J.A.;Lee, Chung-Hao;Azoug, Aurelie;Lu, Hongbing;Wang, Shuodao
• 通讯作者: Wang, Shuodao