SPP 1710: Dynamics of Thiol-Based Redox Switches in Cellular Physiology

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In recent years it has become evident that reactive oxygen and nitrogen species, despite their traditional reputation as components of radical chains and harbingers of damage, act as physiologically essential messengers in signal transduction. The signalling properties of particular oxidants are primarily sensed and mediated by "protein thiol switches", which are protein thiols that are specifically and reversibly modified by oxidation, thereby switching the protein between different conformational and functional states. In spite of the fundamental cell biological and medical importance of thiol switches we are only beginning to understand their principles of specificity, their mechanism of action and their role in the spatio-temporal operation of signal transduction.