SPP 1710: Dynamics of Thiol-Based Redox Switches in Cellular Physiology

SPP 1710：细胞生理学中基于硫醇的氧化还原开关的动力学

• 批准号: 237042534
• 金额: --
• 依托单位: Deutsches Krebsforschungszentrum (DKFZ)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/237042534?language=en
• 关键词: SPP; 1710; Dynamics; Thiol; Based

In recent years it has become evident that reactive oxygen and nitrogen species, despite their traditional reputation as components of radical chains and harbingers of damage, act as physiologically essential messengers in signal transduction. The signalling properties of particular oxidants are primarily sensed and mediated by "protein thiol switches", which are protein thiols that are specifically and reversibly modified by oxidation, thereby switching the protein between different conformational and functional states. In spite of the fundamental cell biological and medical importance of thiol switches we are only beginning to understand their principles of specificity, their mechanism of action and their role in the spatio-temporal operation of signal transduction.

近年来，它已经变得很明显，活性氧和氮的物种，尽管他们的传统声誉作为自由基链的组成部分和损害的预兆，作为生理上必不可少的信使信号转导。特定氧化剂的信号传导性质主要由“蛋白质硫醇开关”感测和介导，所述蛋白质硫醇开关是通过氧化特异性且可逆地修饰的蛋白质硫醇，从而在不同构象和功能状态之间切换蛋白质。尽管硫醇开关具有基本的细胞生物学和医学重要性，但我们才刚刚开始了解它们的特异性原理、它们的作用机制以及它们在信号转导的时空操作中的作用。