Collaborative Research: Fundamental Basis for General Molecular Weight Determination for Ionic Polymers

合作研究：离子聚合物通用分子量测定的基础

• 批准号: 1904746
• 负责人: Louis Madsen
• 金额: $ 12万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1904746&HistoricalAwards=false
• 关键词: Collaborative; Research; Fundamental; Basis; General

With this award, the Macromolecular, Supramolecular and Nanochemistry Program with partial co-funding from the Chemical Measurement and Imaging Program in the Division of Chemistry is funding Dr. Ralph H. Colby from Pennsylvania State University and Dr. Louis A. Madsen from Virginia Polytechnic Institute and State University. The team is developing new methods for measuring the molecular weight of polymers that have attached ions. Polymers are long-chain molecules consisting of many repeating units that are linked together through carbon-carbon bonds. While there are many firmly established techniques used to accurately determine the molecular weight of nonionic (uncharged) polymers, applying such methods to ionic polymers is usually difficult. Ionic polymers are a very important class of polymers used by industry as thickeners in water-based paints and coatings and in water purification technologies. A large fraction of biological molecules, including DNA, RNA, many polypeptides and polysaccharides are also examples of important ionic polymers. This project develops a novel set of robust techniques that determine molecular weights for both natural and synthetic ionic polymers. Development of these new methodologies benefits society by accelerating the development of ion-conducting energy materials and biodegradable materials. Such research activities train students in macromolecular sciences for future employment in polymer (plastics) industries. The development of both materials and workforce are central to keeping US industries globally competitive.This research is focused on developing four methods that utilize easily measured dynamic properties of semidilute unentangled solutions of ionic polymers to obtain the number-average molecular weight. Each method relies on specific combinations of calibrated measurements so that each one directly determines the number density of chains in solution and thus the number-average molecular weight of the polymers in that solution. These four methods each have the advantage that they are insensitive to salt concentration (since salt can be challenging or even impossible to remove) and have the transformative potential to enable routine molecular weight determinations for ionic polymers, while using very little sample. Quick adoption of these methods is anticipated, allowing rapid growth of the development of polyelectrolytes and ionomers to suit a myriad of applications. Development and validation of the theory and experimental methods in this project further impact the physical underpinnings of polymer science and enable new understanding of ionic polymer properties. While mainly being tested and developed using synthetic polymers, this research also promises to enable routine characterization of molecular weight for biopolymers such as hyaluronic acid, heparin, DNA and RNA.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

有了这个奖项，大分子，超分子和纳米化学计划与部分共同资助的化学测量和成像计划在化学部资助博士拉尔夫H。来自宾夕法尼亚州立大学的科尔比和路易斯A. Madsen来自弗吉尼亚理工学院和州立大学。 该团队正在开发测量附着离子的聚合物分子量的新方法。 聚合物是由许多通过碳-碳键连接在一起的重复单元组成的长链分子。 虽然有许多牢固建立的技术用于准确测定非离子（不带电）聚合物的分子量，但将这些方法应用于离子聚合物通常是困难的。 离子聚合物是一类非常重要的聚合物，在工业上用作水基油漆和涂料以及水净化技术中的增稠剂。 大部分生物分子，包括DNA、RNA、许多多肽和多糖也是重要的离子聚合物的实例。 该项目开发了一套新的稳健技术，用于确定天然和合成离子聚合物的分子量。 这些新方法的开发通过加速离子传导能源材料和生物可降解材料的开发而造福社会。 这些研究活动培养学生在高分子科学的未来就业的聚合物（塑料）行业。 材料和劳动力的发展是保持美国工业全球竞争力的核心，本研究的重点是开发四种方法，利用容易测量的离子聚合物的半稀释非缠结溶液的动态特性，以获得数均分子量。 每种方法都依赖于校准测量的特定组合，因此每种方法都直接确定溶液中链的数密度，从而确定该溶液中聚合物的数均分子量。 这四种方法各自具有对盐浓度不敏感的优点（因为盐可能具有挑战性，甚至不可能去除），并且具有变革潜力，能够在使用非常少的样品的同时进行离子聚合物的常规分子量测定。 预计这些方法将迅速采用，从而使聚电解质和离聚物的开发快速增长，以适应无数应用。 该项目中理论和实验方法的发展和验证进一步影响了聚合物科学的物理基础，并使人们对离子聚合物的性质有了新的认识。 虽然主要是使用合成聚合物进行测试和开发，但该研究也有望实现透明质酸、肝素、DNA和RNA等生物聚合物分子量的常规表征。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Quantifying Drug Cargo Partitioning in Block Copolymer Micelle Solutions

• DOI: 10.1021/acsapm.0c00694
• 发表时间: 2020-08
• 作者: Xiuli Li;V. Uppala;Tyler J. Cooksey;Megan L. Robertson;L. Madsen

Strong Variation of Micelle-Unimer Coexistence as a Function of Core Chain Mobility.

• DOI: 10.1021/acs.macromol.1c00635
• 发表时间: 2021-07
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: Ryan J Carrazzone;Xiuli Li;Jeffrey C. Foster;V. Uppala;Candace E. Wall;A. Esker;L. Madsen;John B. Matson