A Biomaterials Strategy to Maintain Functionality in Osteoarthritic Cartilage

维持骨关节炎软骨功能的生物材料策略

• 批准号: 1905673
• 负责人: Mark Grinstaff
• 金额: $ 50万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-15 至 2022-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1905673&HistoricalAwards=false
• 关键词: Biomaterials; Strategy; Maintain; Functionality; Osteoarthritic

Non-Technical sectionSynthetic biomaterials are of critical importance in developing innovative solutions for the repair of soft tissues, such as human cartilage, tendons, valves, and blood vessels. New polymer compositions and polymers with novel properties will precipitate rapid progress in medical device and tissue repair areas. Scientific advances, such as those described in this NSF sponsored research, will potentially lead to tangible improvement in the lives of millions of Americans suffering from osteoarthritis, and other diseases caused by soft tissue degradation. Furthermore, the outcomes will support US pharmaceutical device industries, which play an important role in medical polymers market. US companies have 45% share of a 300 B industry. NSF funding will be used to support undergraduate and graduate students, who will benefit from a cutting-edge interdisciplinary research and educational experience that encompasses training in biomaterials and polymer chemistry. Students will be encouraged to think independently and creatively while recognizing the importance of collaborating with other experts (e.g., materials scientists, pathologist, biomedical engineers, surgeons, entrepreneurs and patent lawyers). These activities will contribute to positive societal outcomes by fostering excitement for fundamental research while educating and training the next generation of academic research and biotechnology workforce.Technical section. Biomaterials are highly sought-after for the repair of soft tissues. However, there are limited solutions to the mechanical wear or failure of human cartilage, tendons, ligaments, sphincters, valves, and blood vessels, which can be caused by aging, disease, or injury. Consequently, there is significant need for new and innovative approaches to restore the material and functional properties of tissues using synthetic biomaterials. With NSF funding, the PI (Grinstaff) and his team will evaluate the performance of an interpenetrating polymer network (IPN) formed between a synthetic hydrophilic biocompatible polymer and osteoarthritic cartilage tissue, as a case study. The synthetic polymer reinforces the tissue and acts like rebar steel in concrete to strengthen the material. Key preliminary data support this new idea and the proposed studies, well-characterized materials and rigorous experimental designs are established, and essential cross-disciplinary collaborations and expertise (biomaterials, tissue culture, biomechanics, etc.) are in place to accomplish the studies. This highly interdisciplinary and cutting-edge research will also prepare educated and trained undergraduate and graduate students for employment in industry and academia.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术部分合成生物材料对于开发修复软组织（例如人体软骨、肌腱、瓣膜和血管）的创新解决方案至关重要。新型聚合物组合物和具有新特性的聚合物将促进医疗器械和组织修复领域的快速进步。科学进步，例如这项由国家科学基金会资助的研究中所描述的科学进步，将有可能使数百万患有骨关节炎和软组织退化引起的其他疾病的美国人的生活得到切实改善。此外，研究结果将支持在医用聚合物市场中发挥重要作用的美国制药器械行业。美国公司在300 B行业中占有45%的份额。美国国家科学基金会的资金将用于支持本科生和研究生，他们将受益于尖端的跨学科研究和教育经验，包括生物材料和高分子化学的培训。我们将鼓励学生独立和创造性地思考，同时认识到与其他专家（例如材料科学家、病理学家、生物医学工程师、外科医生、企业家和专利律师）合作的重要性。这些活动将激发人们对基础研究的兴趣，同时教育和培训下一代学术研究和生物技术劳动力，从而为积极的社会成果做出贡献。技术部分。 生物材料在软组织修复方面备受追捧。然而，对于由衰老、疾病或损伤引起的人体软骨、肌腱、韧带、括约肌、瓣膜和血管的机械磨损或失效，目前的解决方案有限。因此，非常需要新的创新方法来使用合成生物材料恢复组织的材料和功能特性。在 NSF 的资助下，PI (Grinstaff) 和他的团队将评估合成亲水性生物相容性聚合物和骨关节炎软骨组织之间形成的互穿聚合物网络 (IPN) 的性能，作为案例研究。合成聚合物可以增强组织，就像混凝土中的钢筋一样增强材料。关键的初步数据支持了这一新想法和拟议的研究，建立了特性良好的材料和严格的实验设计，并建立了必要的跨学科合作和专业知识（生物材料、组织培养、生物力学等）来完成研究。这项高度跨学科和前沿的研究还将为受过教育和训练的本科生和研究生做好在工业界和学术界就业的准备。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。