The role of gamma glutamyl cyclotransferase in glutathione homeostasis

γ-谷氨酰环转移酶在谷胱甘肽稳态中的作用

• 批准号: DP0880027
• 负责人: Prof Philip Board
• 金额: $ 9.36万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0880027
• 关键词: role; gamma; glutamyl; cyclotransferase; glutathione

The aim of this study is to understand the structure and function of gamma-glutamyl cyclotransferase (GGCT) and its role in glutathione synthesis and turnover. Glutathione is essential for life and serves multiple biological functions protecting against oxidative stress, and aiding in the detoxification and excretion of foreign chemicals. This study will explore a new approach to changing intracellular glutathione concentrations that has wide applications in the treatment of inherited enzyme deficiencies, cancer and the development of herbicide resistant crop plants. The study will also contribute to the training of scientists for the future development of the Australian biotechnology industry

本研究旨在了解γ-谷氨酰环转移酶(GGCT)的结构和功能及其在谷胱甘肽合成和周转中的作用。谷胱甘肽是生命所必需的，具有多种生物功能，可防止氧化应激，并有助于解毒和排泄外来化学物质。本研究将探索一种改变细胞内谷胱甘肽浓度的新方法，该方法在治疗遗传酶缺乏症、癌症和培育抗除草剂作物方面具有广泛的应用。这项研究还将有助于为澳大利亚生物技术产业的未来发展培养科学家