Pharmacogenetic investigations of glutathione transferases

谷胱甘肽转移酶的药物遗传学研究

• 批准号: nhmrc : 316955
• 负责人: Prof Philip Board
• 金额: $ 31.41万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pharmacogenetic-investigations-glutathione-transferases/98060
• 关键词: Pharmacogenetic; investigations; glutathione; transferases

Members of the family of enzymes known as glutathione transferases are known to be responsible for the metabolism and detoxification of a wide range of compounds including therapeutic drugs and cancer causing chemicals. Genetic variation in an individual's compliment of glutathione transferases can alter their response to drug treatment or their susceptibility to cancer. This study will investigate (1)the genetic mechanisms that alter the production of glutathione transferases, (2) the characteristics of a new class of glutathione transferases and (3) the role of glutathione transferase A4 in protecting against disorders such as atherosclerosis and Parkinson's disease.

已知称为谷胱甘肽转移酶的酶家族的成员负责包括治疗药物和致癌化学物质在内的广泛化合物的代谢和解毒。个体谷胱甘肽转移酶的遗传变异可以改变他们对药物治疗的反应或对癌症的易感性。本研究将调查（1）改变谷胱甘肽转移酶产生的遗传机制，（2）一类新的谷胱甘肽转移酶的特性，以及（3）谷胱甘肽转移酶A4在预防动脉粥样硬化和帕金森病等疾病中的作用。