Cellular uptake of glutathione transferases and their development as cell transfection agents

谷胱甘肽转移酶的细胞摄取及其作为细胞转染剂的开发

• 批准号: DP0558315
• 负责人: Prof Philip Board
• 金额: $ 20.1万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0558315
• 关键词: Cellular; uptake; glutathione; transferases; their

The function and survival of all cells requires the importation of a vast array of biochemical agents. In order for this to occur, these agents must be transported across the cell membrane wall. We are investigating a novel delivery system involving the enzyme glutathione transferase (GST). By investigating how GSTs cross membranes, we will be able to develop a new technology for the delivery of biologically active molecules into cells. This exciting new technique will have applications in research and in the delivery of therapeutic drugs for the treatment of a range of diseases.

所有细胞的功能和存活都需要输入大量的生化制剂。为了发生这种情况，这些药物必须通过细胞膜壁运输。我们正在研究一种涉及谷胱甘肽转移酶（GST）的新型递送系统。通过研究GSTs如何跨膜，我们将能够开发一种将生物活性分子输送到细胞中的新技术。这项令人兴奋的新技术将应用于研究和治疗药物的输送，以治疗一系列疾病。