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A genomic and phenomic investigation of a mitochondrial glutathione transferase

A genomic and phenomic investigation of a mitochondrial glutathione transferase
线粒体谷胱甘肽转移酶的基因组和表型组研究
批准号：
DP0343815
负责人：
Prof Philip Board
金额：
$16.75万
依托单位：
The Australian National University
依托单位国家：
澳大利亚
项目类别：
Discovery Projects
财政年份：
2003
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2003-01-01 至 2005-12-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DP0343815
关键词：
genomicphenomicinvestigationmitochondrialglutathione

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英文摘要
The aim of this study is to understand of the genomics, structure and function of glutathione transferase Kappa (GSTK), a novel GST found in mitochondria. The investigations will achieve several outcomes. (1)an understanding of the organisation of GSTK gene(s) in humans and mice; (2) determination of the role of GSTK in mitochondria, by investigating the phenotype of knockout mice; (3) determination of the crystal structure of human GSTK; (4) An understanding of GSTK's substrate specificity, reaction kinetics and structure/function relationships. Since GSTK is confined to mitochondria, and may not be related to other GSTs, we may also identify novel functions
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Glutathione transferase Zeta: A novel regulator of glucose and lipid metabolism
  • 批准号：
    nhmrc : 1052556
  • 项目类别：
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  • 资助金额：
    $40.28万
  • 财政年份：
    2013
  • 负责人：
    Prof Philip Board
  • 依托单位：
    Australian National University
The evaluation of gamma-glutamylcyclotransferase as a novel target for cancer therapy and diagnosis
  • 批准号：
    nhmrc : 525458
  • 项目类别：
    NHMRC Project Grants
  • 资助金额：
    $28.93万
  • 财政年份：
    2009
  • 负责人：
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  • 依托单位：
    Australian National University
The role of gamma glutamyl cyclotransferase in glutathione homeostasis
  • 批准号：
    DP0880027
  • 项目类别：
    Discovery Projects
  • 资助金额：
    $9.36万
  • 财政年份：
    2008
  • 负责人：
    Prof Philip Board
  • 依托单位：
    The Australian National University
Cellular uptake of glutathione transferases and their development as cell transfection agents
  • 批准号：
    DP0558315
  • 项目类别：
    Discovery Projects
  • 资助金额：
    $20.1万
  • 财政年份：
    2005
  • 负责人：
    Prof Philip Board
  • 依托单位：
    The Australian National University
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