The role of Zeta and Omega class glutathione transferases in endobitic and xenobiotc metabolism

谷胱甘肽转移酶在保护细胞免受环境中有害化学物质的侵害方面起着重要作用。虽然一些被谷胱甘肽转移酶解毒的化学物质会导致癌症和其他疾病，但这些酶也会消除化疗中使用的一些药物。细胞中谷胱甘肽转移酶的种类和数量的变化会使正常细胞容易受到致癌化学物质的影响，并使癌细胞对抗癌药物产生抗药性。我们发现了谷胱甘肽转移酶的两种新形式，分别是Zeta和Omega。在这里进行的新研究旨在了解这些新酶在抵御外来化学物质方面的作用以及这些酶在正常细胞代谢中的作用。由于Zeta类谷胱甘肽转移酶是消除过量氨基酸酪氨酸的途径的一部分，我们将确定其抑制是否会为遗传性酪氨酸血症患者提供新的治疗方法。我们还将研究决定细胞中产生的Zeta和Omega谷胱甘肽转移酶数量的遗传和环境因素

The glutathione transferases are enzymes that play a significant role in the protection of cells from harmful chemicals in the environment. While some of the chemicals that are detoxified by glutathione transferases cause cancer, and other diseases, these enzymes also eliminate some of the drugs that are used in chemotherapy. Variations in the type and amount of glutathione transferase in a cell can make a normal cell susceptible to cancer causing chemicals and make a cancer cell resistant to anti cancer drugs. We have discovered two new forms of glutathione transferase called Zeta and Omega. The new research to be undertaken here is aimed at understanding the role of these new enzymes in protection against foreign chemicals and the role these enzymes play in normal cellular metabolism. Because the Zeta class glutathione transferase is part of a pathway designed to eliminate excessive amounts of the amino acid tyrosine, we will determine if its inhibition will provide a new treatment for patients with a disease called hereditary tyrosinemia. We will also study the genetic and environmental factors that determine the amount of Zeta and Omega glutathione transferase produced in cells