MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer for a Cluster of Primarily Undergraduate Institutions in Rhode Island

该奖项由化学仪器(CRIF)计划、既定的激励竞争研究计划(EPSCoR)和重大研究仪器(MRI)计划共同资助。普罗维登斯学院的肖恩·马尔卡希教授和他的同事克里斯托弗·拉珀尔、克里斯托弗·里德(布莱恩特大学)、玛丽亚·卡罗尔和梁展欣(罗德岛学院)正在购买一台400 MHz核磁共振(核磁共振)光谱仪，以更换旧的。总体而言，核磁共振波谱是化学家用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。化学家的典型用途是分析反应产生的混合物以确定产物。这种乐器是普罗维登斯学院以及邻近的罗德岛学院和布莱恩特学院的本科生进行的教学和研究的一个组成部分。它也被用于讲课和实验室课程，为学生的职业生涯做准备。该奖项旨在加强各级的研究和教育。目前正在调查各种研究项目。其中一个项目涉及研究含氮杂环的有机合成和用于化学催化和药物化学应用的β-卡宾阿托品(由于单键旋转受阻而产生的立体异构体)的立体对称制备。对二氧化碳的电催化还原进行了研究，以期对这些化合物进行修复。另一个项目是研究典型的五酮基铁催化的光辅助反应中的溶剂化效应，以改进有机合成中的这一过程。可官能化和可降解的聚合物可能用于医药和环境应用的研究正在进行中。细菌N-乙酰氨基葡萄糖苷酶的小分子抑制剂正在被合成，以促进对细胞壁代谢的了解。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly funded by the Chemical Instrumentation (CRIF) program, the Established Program to Stimulate Competitive Research (EPSCoR), and the Major Research Instrumentation (MRI) program. Professor Seann Mulcahy from Providence College and colleagues Christopher Laperle, Christopher Reid (Bryant University), Maria Carroll and Chin Hin Leung (Rhode Island College) are acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer to replace an older one. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. A typical use by a chemist is to analyze the mixture from a reaction to determine the products. This instrument is an integral element of teaching as well as research performed by undergraduate students at Providence College and neighboring Rhode Island College and Bryant College. It is also used in lecture and laboratory courses to prepare students for their careers. The award is aimed at enhancing research and education at all levels. A variety of research projects are being investigated. One project involves studying the organic synthesis of nitrogen-containing heterocycles and the stereosymmetric preparation of beta-carboline atropisomers (stereoisomers arising because of hindered rotation about a single bond) for chemical catalysis and medicinal chemistry applications. Electrocatalytic reduction of carbon dioxide is studied for possible remediation of the compounds. Another project is investigating solvation effects on prototypical iron pentacarbonyl-catalyzed photoassisted reactions to improve this procedure in organic synthesis. Functionalizable and degradable polymers for possible medicinal use and environmental applications are being investigated. Small molecule inhibitors of bacterial N-acetylglucosaminidases are being synthesized to foster understanding of cell wall metabolism.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.