MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Support Undergraduate Research at High Point University

MRI：采购 400 MHz 核磁共振 (NMR) 波谱仪以支持海波因特大学的本科生研究

• 批准号: 1919685
• 负责人: Pamela Lundin
• 金额: $ 29.95万
• 依托单位: High Point University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919685&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; Nuclear

This award is supported by the Major Research Instrumentation and the Chemistry Instrumentation Programs. Professor Pamela Lundin from High Point University and colleagues Andrew Wommack, Melissa Srougi and Meghan Blackledge are acquiring a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer that replaced an older low-field spectrometer. In general, NMR spectroscopy is one of the most powerful tools available to chemists to determine of the structure of molecules. NMR spectroscopy is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The NMR studies improve understanding of synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate and graduate students and several early career faculty members at this growing institution. While using the instrument, students gain essential analytical skills that allow them to become more competitive candidates for industrial careers and graduate school programs. In addition, the NMR spectrometer is incorporated into the evolving portfolio of instrumentation utilized by this institution's Mobile Community Laboratory. NMR is used to illustrate the concepts of structural chemistry and kinetics to local middle and high school students and to expand participation in STEM (science, technology, engineering and mathematics) programs.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts the characterization of polymerization products such as those of poly(3-hexylthiophene) and poly(phenylene ethynylenes) and the use of thiol-ene coupling reactions to generate redox-inert disulfide bioisosteres. The instrumentation also serves researchers elucidating the mechanism of antidepresant-dibenzazepine inhibition of protein serine/threonine (Stk1) kinase, and those designing, synthesizing and characterizing quinone structures. These research projects benefit the National health and welfare as well as education and diversity efforts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项得到了主要研究仪器和化学仪器项目的​​支持。海波因特大学的 Pamela Lundin 教授及其同事 Andrew Wommack、Melissa Srougi 和 Meghan Blackledge 正在购买一台 400 MHz 核磁共振 (NMR) 光谱仪，以取代旧的低场光谱仪。一般来说，核磁共振波谱是化学家确定分子结构最强大的工具之一。核磁共振波谱用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。核磁共振研究提高了对合成有机/无机化学、材料化学和生物化学的理解。该仪器是这所不断发展的机构的本科生、研究生以及几位早期职业教员进行教学和研究的不可分割的一部分。在使用该仪器时，学生可以获得必要的分析技能，使他们能够成为工业职业和研究生院项目中更具竞争力的候选人。此外，核磁共振波谱仪已被纳入该机构移动社区实验室所使用的不断发展的仪器产品组合中。 NMR 用于向当地中学生阐释结构化学和动力学的概念，并扩大对 STEM（科学、技术、工程和数学）项目的参与。NMR 波谱仪的获奖旨在加强各个级别的研究和教育。它尤其影响聚合产物的表征，例如聚（3-己基噻吩）和聚（亚苯基乙炔）的聚合产物，以及使用硫醇-烯偶联反应生成氧化还原惰性二硫化物生物等排体。该仪器还可以帮助研究人员阐明抗抑郁药二苯并氮杂卓抑制蛋白丝氨酸/苏氨酸 (Stk1) 激酶的机制，以及设计、合成和表征醌结构。这些研究项目有利于国家健康和福利以及教育和多元化工作。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。