MRI: Acquisition of High-Resolution Mass Spectrometer for Research in Materials and Biological Chemistry

该奖项由主要研究仪器和化学仪器计划支持。来自新墨西哥州大学的Jeffrey Rack教授及其同事Martin Kirk和Yang Qin正在获得一种超高压四极杆飞行时间质谱仪（UPLC-QTof-MS）。一般来说，质谱（MS）是用于识别和表征复杂样品中嵌入的少量化学物质的关键分析方法之一。在一个典型的实验中，成分流入质谱仪，在那里它们被电离成离子，并测量离子的质量。这种高灵敏度的技术可以研究复杂混合物中的分子结构。带有液相色谱仪的仪器可以在化合物到达质谱仪之前将其分离。使用质谱的飞行时间方法，通过时间测量的方式确定离子的质荷比，其中离子被已知强度的电场加速。这种加速导致离子具有与具有相同电荷的任何其他离子相同的动能。此次收购加强了大学和地区的研究基础设施。该工具扩大了参与范围，让不同群体的学生参与使用这一现代分析技术的研究和研究培训，并为许多用户和代表性不足的学生提供支持。它还为本科生提供培训机会，其中许多是第一代学生。该仪器为学生提供了使用重要仪器的经验，他们随身携带到他们的职业生涯。该质谱仪的奖项旨在加强各级研究和教育。它对于开发光活性化合物和材料以及设计分子电子学的支撑磁性材料特别有用。该仪器还用于评估灵活的光电应用和开发平台筛选生物活性物质库的聚硫属亚乙烯基共轭聚合物。质谱仪还用于表征可能与尼曼-尼曼模型相关的通用结构。选择与肝脏和脾脏疾病相关的C1代谢途径，并破译一氧化氮合酶的构象控制以及用稳定同位素标记潜在药物该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准。

This award is supported by the Major Research Instrumentation and the Chemical Instrumentation Programs. Professor Jeffrey Rack from the University of New Mexico and colleagues Martin Kirk and Yang Qin are acquiring an ultra high-pressure, quadrupole, time-of-flight mass spectrometer (UPLC-QTof-MS). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are ionized into ions and the ions' masses are measured. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer. Using the time-of-flight method of mass spectrometry, the mass-to-charge ratio of an ion is determined by the way of a time measurement in which ions are accelerated by an electric field of known strength. This acceleration results in an ion having the same kinetic energy as any other ion that has the same charge. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse groups of students in research and research training using this modern analytical technique and supports many users and underrepresented students. It also provides training opportunities to undergraduate students, many of whom are first-generation students. The instrument gives students experience using vital instrumentation that they carry with them into their careers.The award of this mass spectrometer is aimed at enhancing research and education at all levels. It is especially useful for developing photoactive compounds and materials and for designing support magnetic materials for molecular electronics. The instrument is also employed in evaluating polychalcogenylene vinylene conjugated polymers for flexible optoelectronic applications and for developing platforms for screening libraries of bioactive species. The mass spectrometer is also utilized for the characterization of generic architectures that may be related to the Niemann-Pick C1 metabolic pathway associated with liver and spleen disorders and for deciphering the conformational control of nitric oxide synthases as well as labeling potential drugs with stable isotopesThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.