Symposium: Building Bridges from Genome to Phenome: Molecules, Methods and Models, Austin, TX; January 3-7, 2020

该奖项将支持一个研讨会，“从基因组到表型组的桥梁：分子，方法和模型”，在德克萨斯州奥斯汀举行的综合和比较生物学学会（SICB）年会上，2020年1月3日至7日。口头和海报介绍及相关活动将涵盖广泛的科学努力，以了解基因如何塑造物种特有的特征，同时也引起个体变异。理解基因引起表型稳定性和变异的机制基础是NSF提出的重大挑战之一。许多学科的科学家正在采取各种各样的方法来剖析基因引起表型的机制基础，称为基因组到表型组研究。本次研讨会的目标是在这些研究工作中最成功的研究工作之间建立联系，并确定关键差距和未来需求，以加速和促进这一关键研究领域。搭建桥梁专题讨论会的活动旨在鼓励和支持现有和新的研究人员以及代表性别和种族多样性的博士后、研究生和本科生研究人员的介绍和参与，并在SICB内所代表的广泛学科中具有专门知识。总的来说，研讨会的活动旨在促进快速和深刻的进展，了解恒定和变化的过程，使物种在不断变化的世界中具有弹性。研讨会的演讲，以及研讨会和相关活动的总结论文将通过在SICB杂志上发表而广泛传播。研讨会由NSF支持的动物基因组到表型组研究协调网络（AG 2 P RCN）的成员组织，该网络成立于五年前。AG 2 P RCN的第一次研讨会和政策研讨会在2016年SICB会议上举行。该讲习班产生的白色文件强调，需要对转录组数据的分析进行标准化和降低障碍，以便来自许多学科和研究环境的科学家能够为将基因组多样性与表型多样性联系起来的“出发点”制定协商一致的方法。自2016年以来，实验生物以及描述各种生物组织水平的大型复杂数据集大量增加，所有这些都旨在阐明基因组到表型组框架的各个方面。2020年搭建桥梁研讨会旨在确定和弥合这一框架中的差距，以及基因组到表型组研究最有前途的未来方向。除了口头和海报介绍外，专题讨论会还包括一次介绍性会议，以启动思想和联系信息的交流，（2）一个Twitter feed，以收集SICB成员关于跨学科、组织级别和模型整合数据的主要障碍的评论，（3）一个政策研讨会，以概述一份白色文件，确定主要差距，在基因组到表型组研究领域的主要障碍和领先优势。研讨会和相关活动将采用跨学科的合作模式，为参与者提供有意义的专业和科学发展机会，以及跨学科、性别、种族和专业级别相互交流的正式和非正式机会。研讨会上的所有演讲将发表在SICB杂志上，从而将被广泛传播，并对该领域产生更广泛的影响。本次会议由NSF-BIO内的综合生态生理学和生理机制以及生物力学计划共同资助。综合有机生物学。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值进行评估，被认为值得支持和更广泛的影响审查标准。

This award will support a symposium, "Building Bridges from Genome to Phenome: Molecules, Methods and Models," at the Annual Meeting of the Society for Integrative and Comparative Biology (SICB) meeting in Austin, Texas, Jan. 3-7, 2020. The oral and poster presentations and related activities will cover a broad range of scientific efforts to understand how genes can shape species-specific characteristics while also giving rise to individual variation. Understanding the mechanistic basis by which genes give rise to both stability and variation in phenotypes is one of the Grand Challenges articulated by NSF. Scientists in many disciplines are taking a wide variety of approaches to dissect the mechanistic bases by which genes give rise to phenotypes, called genome-to-phenome studies. The goal of this Symposium will be to build connections among the most successful of these research efforts, as well as to identify key gaps and future needs to accelerate and facilitate this critical area of research. Activities of the Building Bridges Symposium are designed to encourage and support presentations and participation by established and new investigators, as well as postdoctoral, graduate and undergraduate researchers representing diversity in gender and ethnicity, and with expertise in the wide range of disciplines represented within SICB. Taken together, the Symposium activities aim to facilitate rapid and insightful progress toward understanding the processes underlying constancy and variation, making it possible for species to be resilient in a changing world. Presentations from the Symposium, and a summary paper resulting from the Symposium and associated activities, will be widely disseminated via publication in the SICB journal.The Symposium is organized by members of the NSF-supported Animal Genome-to-Phenome Research Coordination Network (AG2P RCN), which was established five years ago. The AG2P RCN's first symposium and policy workshop were conducted at the 2016 SICB Meeting. The white paper resulting from that workshop emphasized the need to standardize and lower the barriers for analysis of transcriptomic data, so that scientists from many disciplines and research environments could develop consensus approaches for the "taking-off point" for linking genomic with phenotypic diversity. Since 2016, there has been a huge proliferation of experimental organisms as well as of large and complex datasets describing various levels of biological organization, all aiming to elucidate aspects of the genome-to-phenome framework. The 2020 Building Bridges Symposium aims to identify and bridge gaps in this framework and the most promising future directions for genome-to-phenome research. In addition to oral and poster presentations, the Symposium includes an introductory session to initiate exchange of ideas and contact information, (2) a Twitter feed to gather comments from SICB members regarding major barriers to integrating data across disciplines, levels of organization and models, and (3) a policy workshop to outline a white paper identifying major gaps, key barriers and leading edges in the field of genome-to-phenome research. The Symposium and related activities will use an interdisciplinary collaborative model that will provide meaningful professional and scientific development opportunities as well as formal and informal opportunities for participants to network with each other across disciplines, gender, ethnicity, and professional ranks. All presentations in the Symposium will be published in the SICB journal and thereby will be widely disseminated and have abroader impact on the field.This conference is being co-funded by the Integrative Ecological Physiology and Physiological Mechanisms and Biomechanics Programs within NSF-BIO-Integrative Organismal Biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.