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EAGER: Non-invasive monitoring of arterial parameters via model-based analysis of arterial pulse signals measured by a microfluidic-based tactile sensor

EAGER：通过基于微流体的触觉传感器测量的动脉脉搏信号进行基于模型的分析，对动脉参数进行无创监测

基本信息

批准号：
1936005
负责人：
Julie Zhili Hao
金额：
$ 19.99万
依托单位：
Old Dominion University Research Foundation
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1936005&HistoricalAwards=false
关键词：
EAGER Non invasive monitoring arterial

项目摘要

With cardiovascular diseases being the leading cause of death worldwide, there is an ever-increasing need for non-invasive monitoring of cardiovascular health and physiology. To be effective and widely used, monitoring methods must be relatively simple, affordable, and accurate. This EArly-concept Grant for Exploratory Research (EAGER) project seeks to develop a novel method for non-invasive monitoring of the cardiovascular system using a microfluidic-based tactile sensor and associated model-based analysis. This project will also reveal sensor-artery interaction physics that is critical for achieving accurate and repeatable measurements. If successful, this method will revolutionize cardiovascular health assessment and tracking by 1) allowing early detection and timely intervention and treatment assessment of cardiovascular diseases, thus reducing morbidity/mortality rates and lowering healthcare costs; and 2) offering a reliable, affordable, and convenient tool to the medical field to conduct extensive clinical studies and large epidemiological surveys to understand cardiovascular physiology and pathology. This project will also train students with fundamental scientific knowledge and experimental skills, and implement several outreach activities, including research open houses and summer-camps for local high school students.In this project, a microfluidic-based tactile sensor with location-insensitive configuration is used to measure the pulse signal in an artery at the skin surface. By treating the measured pulse signal as a vibration signal, the arterial wall is modeled as a second-order dynamic system. Consequently, the associated model-based analysis allows estimation of three arterial parameters (elasticity, viscosity and radius of the arterial wall) from only one measured pulse signal. The overall goal of this project is to gain fundamental understanding on how estimated arterial parameters and their concomitant changes depend on the sensor design under different subject-specificity (Body Mass Index and age) and to establish correlations of the estimated values with other CV system parameters. The technical objectives of the project are to: 1) experimentally investigate the dependence of estimated arterial parameters and their changes on the sensor design under different subject-specificity; 2) assess the measurement accuracy and repeatability by relevant medical readings; 3) based on the experimental results and relevant engineering principles, establish a theoretical framework on quantitative relations of the estimated values of arterial parameters to the sensor design under different subject-specificity; and 4) examine correlations of estimated arterial parameters and their changes with other CV parameters.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

随着心血管疾病成为全球死亡的主要原因，对心血管健康和生理的非侵入性监测的需求不断增加。为了有效并广泛使用，监测方法必须相对简单、经济实惠且准确。EARLY概念探索性研究资助（EAGER）项目旨在开发一种新的方法，使用基于微流体的触觉传感器和相关的基于模型的分析对心血管系统进行无创监测。该项目还将揭示传感器-动脉相互作用物理学，这对于实现准确和可重复的测量至关重要。如果成功，该方法将通过以下方式彻底改变心血管健康评估和跟踪：1）允许心血管疾病的早期检测和及时干预和治疗评估，从而降低发病率/死亡率并降低医疗保健成本;和2）提供可靠的，负担得起的，和方便的工具，医疗领域进行广泛的临床研究和大型流行病学调查，以了解心血管生理学，病理本项目还将培养学生的基础科学知识和实验技能，并为当地高中生开展研究开放日和夏令营等多项外展活动。在本项目中，使用具有位置不敏感配置的基于微流体的触觉传感器来测量皮肤表面动脉中的脉搏信号。通过将所测量的脉搏信号视为振动信号，动脉壁被建模为二阶动力学系统。因此，相关联的基于模型的分析允许仅根据一个测量的脉搏信号来估计三个动脉参数（动脉壁的弹性、粘度和半径）。本项目的总体目标是从根本上了解估计的动脉参数及其伴随变化如何取决于不同受试者特异性（体重指数和年龄）下的传感器设计，并建立估计值与其他CV系统参数的相关性。本项目的技术目标是：1）实验研究不同受试者特异性下估计的动脉参数及其变化对传感器设计的依赖性; 2）通过相关医学读数评估测量准确性和重复性; 3）根据实验结果和有关工程原理，建立不同受试者特异性下动脉参数估计值与传感器设计之间定量关系的理论框架;和4）检查估计的动脉参数及其变化与其他CV参数的相关性。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。