Planning Grant: Engineering Research Center for Innovative Materials and Processes for Antimicrobial Control Technologies (IMPACT)
规划资助:抗菌控制技术创新材料与工艺工程研究中心(IMPACT)
基本信息
- 批准号:1936926
- 负责人:
- 金额:$ 10万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Proposal Number: 1936926Planning Grant: Engineering Research Center for Innovative Materials and Processes for Antimicrobial Control Technologies (IMPACT) Abstract:Part 1: Planning activities are being pursued by this cross-institutional team to develop the Engineering Research Center for Innovative Materials and Processes for Antimicrobial Control Technologies (ERC-IMPACT). The mission of IMPACT is to advance antimicrobial control technologies through innovations in science, engineering, and education. It is motivated by the rapid increase in antimicrobial resistant infections, which have become a major challenge to human health. It is predicted that superbug infections will cause more deaths than all cancers combined by 2050 if no effective controls are found. Microbes can survive the attack of antimicrobials either through genetic elements (i.e. superbugs) or by forming surface-attached biofilms. Addressing the grand challenge of antimicrobial-resistant infection requires major collaborative efforts of convergent research to understand the mechanism of antimicrobial resistance, engineer more effective biomaterials and medical devices, and develop better regulatory guidelines to ensure the safety of medical implants. This multidisciplinary team will take the ERC planning opportunity to engage stakeholders and prioritize the activities in research, education, industrial collaboration, and outreach to build a solid foundation for a competitive ERC application. The planning grant will enable team-building and structuring of IMPACT that will subsequently lead to transformative broader impacts on healthcare and biosecurity through innovation in microbial control technologies and processes; development of cross-disciplinary expertise and workforce; building academia-industry partnerships with a culture that encourages diversity and inclusion; strategic engagement with national and global partners; and a sustainable innovation ecosystem that can attract funding and resources for a successful future.Part 2: The Engineering Research Center for Innovative Materials and Processes for Antimicrobial Control Technologies (ERC-IMPACT) will lead breakthroughs in science and technology to address the grand challenge of antimicrobial resistant infections. Such infections come both from mechanisms of natural selection and from biofilm formation. In particular, the design of medical devices and biomaterials has to this point focused almost exclusively on the main function of the device itself and safety to the host, i.e., healing. The competing microbial factors from both pathogens and the host microbiome are largely unexplored. Thus, the material properties that not only promote healing but also resist infection over time are not well understood. Similarly, there is a lack of effective biofilm control strategies. Currently available antimicrobials were discovered using drug screening platforms that only target the growth of planktonic (free-swimming) microbial cells. With the conventional antimicrobials being ineffective, new treatment methods are urgently needed, particularly in the context of tissue-contacting biomaterials/devices that are so critical to human health. ERC-IMPACT will bridge knowledge gaps and provide solutions based on rational design to address the grand challenge of antimicrobial resistance and its role in device-associated infections. ERC-IMPACT will: (1) forge convergent research to understand and control the complex interactions between different microbial species, host cells, and implanted biomaterials; (2) engineer new materials and devices to actively sense and respond to microbial infections; and (3) develop new control methods that do not require conventional antimicrobials or minimize the use through synergistic activities. To accelerate the evolution of the envisioned ERC, the team will engage with stakeholders in academia (university partners including minority-serving institutions), industry (small and large-scale companies, start-ups, research and development facilities), technology translation (patents, manufacturing, scalability, entrepreneurship), education (graduate, undergraduate, local schools, online learning), professionals (postdocs, veterans), and the broader community. The planning team will develop a strategic partnership that encompasses the four components central to the ERC program model - fundamental research, workforce development; diversity and inclusion; and innovation. The state-of-the-art ERC IMPACT center will build long-term engagement plans for stakeholders to fulfill its mission of innovation and to serve the community for better human health and a prosperous future.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
摘要:第一部分:这个跨机构团队正在进行规划活动,以发展抗菌控制技术创新材料和工艺工程研究中心(ERC-IMPACT)。IMPACT的使命是通过科学、工程和教育方面的创新来推进抗菌控制技术。它的动机是抗微生物药物耐药性感染的迅速增加,这已成为对人类健康的重大挑战。据预测,如果没有有效的控制措施,到2050年,超级细菌感染造成的死亡人数将超过所有癌症的总和。微生物可以通过遗传因素(即超级细菌)或通过形成表面附着的生物膜来抵抗抗菌剂的攻击。应对抗微生物药物耐药性感染的巨大挑战,需要开展大量的协同研究,以了解抗微生物药物耐药性的机制,设计更有效的生物材料和医疗设备,并制定更好的监管指南,以确保医疗植入物的安全性。这个多学科团队将利用ERC规划机会与利益相关者合作,并优先考虑研究、教育、工业合作和外展活动,为具有竞争力的ERC应用奠定坚实的基础。规划赠款将用于团队建设和构建IMPACT,随后通过微生物控制技术和流程的创新,对医疗保健和生物安全产生变革性的更广泛影响;发展跨学科的专业知识和人才队伍;以鼓励多元化和包容性的文化,建立学术界与产业界的合作伙伴关系;与国家和全球伙伴的战略接触;以及一个可持续的创新生态系统,为成功的未来吸引资金和资源。第二部分:抗菌素控制技术创新材料和工艺工程研究中心(ERC-IMPACT)将引领科技突破,解决抗菌素耐药性感染的巨大挑战。这种感染既来自自然选择机制,也来自生物膜的形成。特别是,医疗设备和生物材料的设计到目前为止几乎完全集中在设备本身的主要功能和对宿主的安全性上,即愈合。来自病原体和宿主微生物组的竞争微生物因素在很大程度上尚未被探索。因此,随着时间的推移,不仅促进愈合而且抵抗感染的材料特性还没有得到很好的理解。同样,缺乏有效的生物膜控制策略。目前可用的抗菌剂是通过药物筛选平台发现的,这些平台仅针对浮游(自由游动)微生物细胞的生长。由于常规抗菌剂无效,迫切需要新的治疗方法,特别是在对人类健康至关重要的组织接触生物材料/设备的背景下。ERC-IMPACT将弥合知识差距,并提供基于合理设计的解决方案,以应对抗菌素耐药性的巨大挑战及其在器械相关感染中的作用。ERC-IMPACT将:(1)形成融合研究,以理解和控制不同微生物物种、宿主细胞和植入生物材料之间复杂的相互作用;(2)设计新材料和新设备,积极感知和应对微生物感染;(3)开发不需要常规抗微生物药物或通过协同活动尽量减少使用的新控制方法。为了加速设想的ERC的发展,该团队将与学术界(包括少数族裔服务机构在内的大学合作伙伴)、行业(小型和大型公司、初创企业、研发机构)、技术翻译(专利、制造、可扩展性、创业)、教育(研究生、本科生、本地学校、在线学习)、专业人士(博士后、退伍军人)和更广泛的社区的利益相关者进行接触。计划团队将发展一种战略合作伙伴关系,包括ERC项目模型的四个核心组成部分:基础研究、劳动力发展;多样性和包容性;和创新。最先进的ERC IMPACT中心将为利益相关者建立长期参与计划,以实现其创新使命,并为更好的人类健康和繁荣的未来服务于社区。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dacheng Ren其他文献
Controlling persister cells of <em>Pseudomonas aeruginosa</em> PDO300 by (<em>Z</em>)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5<em>H</em>)-one
- DOI:
10.1016/j.bmcl.2013.06.011 - 发表时间:
2013-08-15 - 期刊:
- 影响因子:
- 作者:
Jiachuan Pan;Fangchao Song;Dacheng Ren - 通讯作者:
Dacheng Ren
Materials and surface engineering to control bacterial adhesion and biofilm formation: A review of recent advances
- DOI:
10.1007/s11705-014-1412-3 - 发表时间:
2014-01-30 - 期刊:
- 影响因子:4.500
- 作者:
Huan Gu;Dacheng Ren - 通讯作者:
Dacheng Ren
The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection: Summary from the in vitro section
2023年骨科研究会肌肉骨骼感染国际共识会议:体外部分总结
- DOI:
10.1002/jor.25774 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Noreen J. Hickok;Bingyun Li;Ebru Oral;S. Zaat;David A. Armbruster;Gerald J. Atkins;Antonia F. Chen;Débora C. Coraça‐Huber;Tianhong Dai;Edward M. Greenfield;Rajendra Kasinath;Matthew Libera;Cláudia N H Marques;T. Fintan Moriarty;K. Scott Phillips;Kapil Raghuraman;Dacheng Ren;Lia Rimondini;K. Saeed;Thomas P. Schaer;Edward M. Schwarz;Christopher Spiegel;P. Stoodley;Vi Khanh Truong;Shao‐Ting Jerry Tsang;B. Wildemann;A. R. Zelmer;A. Zinkernagel - 通讯作者:
A. Zinkernagel
Weak centers and local critical periods for a Z2- equivariant cubic system
Z2-等变立方系统的弱中心和局部临界期
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:5.6
- 作者:
Ting Chen;Wentao Huang;Dacheng Ren - 通讯作者:
Dacheng Ren
Dacheng Ren的其他文献
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{{ truncateString('Dacheng Ren', 18)}}的其他基金
Developing Rational Design Principles for Textured Medical Device Surfaces
制定纹理医疗器械表面的合理设计原则
- 批准号:
2037856 - 财政年份:2020
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
Rational Design of Dynamic Antifouling Material Topographies for Safer Medical Devices
合理设计动态防污材料形貌,提高医疗器械安全性
- 批准号:
1836723 - 财政年份:2018
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
EAGER: Collaborative Research: Integrating microtome sectioning with isotopic tracing to study biotransformation in synthetic Escherichia coli biofilms
EAGER:合作研究:将切片机切片与同位素示踪相结合,研究合成大肠杆菌生物膜的生物转化
- 批准号:
1700935 - 财政年份:2017
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
Integrating synthetic biology approaches with patterned biofilm formation to investigate bacterial persistence in heterogeneous structures
将合成生物学方法与图案化生物膜形成相结合,研究异质结构中的细菌持久性
- 批准号:
1706061 - 财政年份:2017
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
MRI: Acquisition of a fluorescence activated cell sorter
MRI:获取荧光激活细胞分选仪
- 批准号:
1337787 - 财政年份:2013
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
EFRI-MIKS: Deciphering and Controlling the Signaling Processes in Bacterial Multicellular Systems and Bacteria-Host Interactions
EFRI-MIKS:破译和控制细菌多细胞系统和细菌-宿主相互作用中的信号传导过程
- 批准号:
1137186 - 财政年份:2011
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
CAREER: Patterned Biofilm Formation by Surface Design: Linking Structure to Physiology and Genetics
职业:通过表面设计形成图案化生物膜:将结构与生理学和遗传学联系起来
- 批准号:
1055644 - 财政年份:2011
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
Collaborative Research: Investigating Bacteria-Surface Interactions by Surface Engineering and Mathematical Modeling
合作研究:通过表面工程和数学建模研究细菌与表面的相互作用
- 批准号:
0826288 - 财政年份:2008
- 资助金额:
$ 10万 - 项目类别:
Standard Grant
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