Mid-scale RI-2 Consortium: Network for Advanced NMR

核磁共振波谱（NMR）是研究分子结构和动力学的重要工具。该奖项将支持在美国建立地理分布的高级核磁共振（NAN）网络，以提供超高场核磁共振光谱仪，使用户能够解决重要和多样化的科学问题，并教育和培训下一代科学家和工程师。这些系统支持的科学研究领域涵盖了结构生物学、动力学和不同生物系统功能的广泛问题，从分子到整个细胞和组织、复杂混合物、代谢组学和天然产物。非生物应用包括但不限于非晶材料、电池组件、药物成分、纳米材料、表面涂层和催化剂。用户支持和培训将通过社区外展和广泛的在线教程、协议、核磁共振脉冲序列和其他技术材料的“知识库”提供。任何机构的远程用户都可以携带或发送他们的样本，以利用NAN资源。有针对性地向本科生和少数民族服务机构推广将促进NMR研究社区的广泛参与。综合起来，增强的网络基础设施和新仪器将有助于解决国家在高场核磁共振能力方面的不足。培训和支持更多的研究人员和新的变革性研究将服务于NSF的任务优先，以推进所有科学和工程领域。网络将采用轮辐式模式，动态适应不断变化的社区需求。康涅狄格大学的中心将促进美国研究人员获得最先进的核磁共振仪器、实验方案和专家。现有的网络基础设施将被利用和扩展，以满足大型研究人员社区的存储、分析和数据重用需求。该项目还包括计划购买两台1.1 GHz核磁共振光谱仪，用于安装在NAN辐条位置。其中一个系统将安装在威斯康星大学，用于固态核磁共振研究。第二个系统将安装在乔治亚大学，专门用于溶液核磁共振研究。随着美国现有仪器的加入，将增加更多的成员地点。重要的努力将指向核磁共振技术的进步，包括改进光谱灵敏度、分辨率、弛豫动力学、间接检测、采样、机器学习和其他方法。一旦建立，NAN将以分层支持水平运行，以支持美国研究人员寻求使用新的1.1 Ghz高场核磁共振系统或其他21个核磁共振300-900 MHz仪器中的一个。改进和分布式利用这些庞大的核磁共振系统是核磁共振系统的一个关键优势。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Nuclear magnetic resonance spectroscopy (NMR) is an essential tool for research into molecular structures and dynamics. This award will support the establishment of a geographically distributed Network for Advanced NMR (NAN) in the U.S. to provide ultra-high field NMR spectrometers to allow users to tackle important and diverse scientific problems and to educate and train the next generation of scientists and engineers. Scientific research areas enabled by these systems cover a wide range of problems in structural biology, dynamics and function of different biological systems from molecules to whole cells and tissues, complex mixtures, metabolomics, and natural products. Non-biological applications include, but are not limited to, amorphous materials, battery components, pharmaceutical ingredients, nanomaterials, surface coatings, and catalysts. User support and training will be provided through community outreach and an extensive “KnowledgeBase” of online tutorials, protocols, NMR pulse sequences, and additional technical materials. Remote users at any institution will be able to bring or send their samples to take advantage of NAN resources. Targeted outreach to undergraduate and minority serving institutions will promote broadening participation in the NMR research community. In combination, the enhanced cyberinfrastructure and new instruments will help to address a national deficit in high-field NMR capacity. Training and enabling more researchers and new transformative research will serve the NSF mission priority to advance all fields of science and engineering.The NAN will operate by a hub and spoke model that dynamically adapts to meet evolving community needs. The hub at the University of Connecticut will facilitate access to state-of-the-art NMR instrumentation, experimental protocols, and experts by US researchers. Existing cyberinfrastructure will be leveraged and expanded to serve the storage, analysis, and data-reuse needs for a large community of researchers. The project also includes plans to purchase two 1.1 GHz NMR spectrometers for installation at the NAN spoke locations. One system will be installed at University of Wisconsin for solid-state NMR research. The second system will be installed at the University of Georgia and be dedicated to solution NMR studies. Additional locations will be added as the NAN expands to incorporate more member locations with existing instrumentation in the U.S. Significant efforts will be directed toward the advancement of NMR technology, including improvements for spectral sensitivity, resolution, relaxation dynamics, indirect detection, sampling, machine learning and other methods. Once established, the NAN will operate with tiered support levels to both enable and support U.S. researchers seeking to use the new 1.1 Ghz high-field NMR systems or one of the 21 other NMR 300-900 MHz instruments available at other locations. Improved and distributed utilization of this large complement of NMR systems is a key benefit of the NAN.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.