Miniaturized mass spectrometry using lithographically patterned electrodes

使用光刻图案化电极的小型化质谱分析

• 批准号: 1404886
• 负责人: Daniel Austin
• 金额: $ 42万
• 依托单位: Brigham Young University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-15 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1404886&HistoricalAwards=false
• 关键词: Miniaturized; mass; spectrometry; using; lithographically

Professors Daniel E. Austin and Aaron R. Hawkins of Brigham Young University are supported by the Chemical Measurement and Imaging (CMI) Program in the Division of Chemistry to explore viable pathways to fabricate highly miniaturized linear-type ion trap mass spectrometers. The goal of this project is to develop a low cost, simple to manufacture, portable mass spectrometer and to demonstrate its applicability to fast on-site chemical measurement problems. One such application is the monitoring of atmospheric particulates. A wide range of scientific and technical areas, including industrial, environmental, clinical, and air quality monitoring, can benefit from on-site mass spectrometric chemical analysis. This is ultimately an instrument development project, and like all new and improved measurement tools it will facilitate advances in science and technology areas that rely on these measurements.The proposed research is focused on the development of a miniaturized linear ion trap (LIT) mass spectrometer (MS), using two parallel ceramic plates onto which all necessary electrodes are lithographically patterned. The proposed two-plate concept will allow precise alignment of the electrodes, a requirement for maintaining acceptable MS resolution, mass accuracy, and selectivity with miniaturized MS. With one plate fixed, only the position of the second plate will be varied using both mechanical as well as fine piezoelectric alignments. After the plates are aligned, they will be permanently affixed with epoxy to create a miniaturized MS analyzer. Once assembled, the analyzer will be interfaced to a commercial GC to demonstrate portable GC-MS operations. The instrument construction and testing tasks involve interdisciplinary education and training of graduate and undergraduate students in chemistry and electrical engineering, two areas that increasingly work together in instrument development and for which cross-training is particularly valuable.

丹尼尔教授E.奥斯汀和亚伦R.杨百翰大学的霍金斯得到了化学系化学测量和成像（CMI）项目的支持，以探索制造高度小型化线性离子阱质谱仪的可行途径。 本计画的目标是发展一种低成本、制造简单、可携式的质谱仪，并证明其适用于快速现场化学测量问题。 一种这样的应用是监测大气颗粒物。 广泛的科学和技术领域，包括工业，环境，临床和空气质量监测，可以从现场质谱化学分析中受益。 这最终是一个仪器开发项目，和所有新的和改进的测量工具一样，它将促进依赖这些测量的科学和技术领域的进步。拟议的研究重点是开发小型化线性离子阱（LIT）质谱仪（MS），使用两个平行的陶瓷板，所有必要的电极都被光刻图案化。 所提出的双板概念将允许电极的精确对准，这是维持可接受的MS分辨率、质量精度和小型化MS的选择性的要求。在一个板固定的情况下，仅第二板的位置将使用机械对准和精细压电对准两者来改变。 板对齐后，将用环氧树脂永久固定，以创建小型化MS分析仪。 组装完成后，分析仪将与商业GC连接，以演示便携式GC-MS操作。 仪器的建设和测试任务涉及跨学科的教育和培训的研究生和本科生在化学和电气工程，这两个领域越来越多地在仪器开发和交叉培训是特别有价值的合作。