MRI: Acquisition of a flow cytometer to enhance undergraduate research at Wellesley College

MRI：购买流式细胞仪以加强韦尔斯利学院的本科生研究

• 批准号: 2018337
• 负责人: Steven Biller
• 金额: $ 37.17万
• 依托单位: Wellesley College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018337&HistoricalAwards=false
• 关键词: MRI; Acquisition; flow; cytometer; enhance

An award is made to Wellesley College to support the purchase of a new flow cytometer. The system will allow students and faculty to make highly sensitive measurements of the properties of individual cells within large populations and at multiple fluorescence wavelengths. Students and faculty will use the flow cytometer to address questions in diverse areas of scientific research, examining systems ranging from aquatic bacteria to eukaryotic cells and working in both the lab and field. Providing students the opportunity to conduct cutting-edge science using modern instrumentation is an important part of undergraduate training. As such, the flow cytometer will also be used in Wellesley's laboratory courses, providing our students with opportunities to learn about current high-throughput analytical techniques through hands-on, student-directed research projects. The new flow cytometer will enable novel areas of scientific inquiry to be carried out across multiple departments at Wellesley. Researchers will use the cytometer to study a range of topics, including: extracellular vesicle-mediated interaction dynamics; the structure and abundance of microbial populations in lake ecosystems; compartment-specific redox dynamics; protein-protein interactions; mechanisms of anti-microbial peptide interactions with bacterial membranes; and ploidy discrimination studies in populations of invasive grasses. Results from the research performed with this instrumentation will be disseminated in peer-reviewed scientific journal publications and at scientific meetings.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

韦尔斯利学院获奖，以支持购买新的流式细胞仪。该系统将允许学生和教职员工在多个荧光波长下对大群体中单个细胞的属性进行高度敏感的测量。学生和教职员工将使用流式细胞仪解决不同科学研究领域的问题，检查从水生细菌到真核细胞的各种系统，并在实验室和现场工作。为学生提供使用现代仪器进行尖端科学的机会是本科培养的重要组成部分。因此，流式细胞仪也将用于卫尔斯理的实验室课程，为我们的学生提供机会，通过动手的、学生指导的研究项目学习当前的高通量分析技术。新的流式细胞仪将使韦尔斯利的多个部门能够进行新的科学研究领域。研究人员将使用细胞仪研究一系列主题，包括：细胞外囊泡介导的相互作用动力学；湖泊生态系统中微生物种群的结构和丰度；特定隔室的氧化还原动力学；蛋白质-蛋白质相互作用；抗菌肽与细菌膜相互作用的机制；以及入侵草类种群的倍性识别研究。使用该仪器进行的研究结果将在同行评议的科学期刊出版物和科学会议上传播。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。