MRI: The Acquisition of a Flow Cytometer to Enhance Research and Training at South Carolina Undergraduate Institutions in the Upstate

福曼大学获得了一个奖项，以支持购买流式细胞仪，以加强南卡罗来纳州北部的研究和培训。流式细胞术是同时分析细胞内或类似大小的物体内的多个生物和/或化学靶标的有力工具。它具有速度，灵敏度和鲁棒性，可以分析大型异质样本中的稀有群体，使其成为一种重要的分析工具，将用于Furman生物学，化学和神经科学课程中以教师为主导，以学生为中心的研究，这是一个研究活跃的Primitive本科院校（PUI）。此外，教师和学生的研究工作在其他区域PUI将受益于获得这种设备。购买流式细胞仪将使三个参与机构每年至少50名学生和教师的高影响力参与。通过多个活跃的NSF夏季研究计划，来自区域PUI，HBCU，两年制学院和第一代服务机构的其他教师和学生将直接受益于该仪器。学院领导的研究项目是弗曼为科学本科生提供参与式学习的愿景的基石。获得流式细胞仪将使各种研究成为可能，包括（1）淋巴细胞系细胞中活化诱导的染色质去凝聚;（2）聚二乙炔脂质体作为传感器和成像剂;（3）活性氧类真菌的影响;（4）新型PI 3 K抑制剂的开发;（5）高脂饮食影响的性别差异;（6）RNA结合蛋白;（7）干细胞生物学。该奖项反映了NSF的法定使命，并被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

An award is made to Furman University to support the acquisition of a flow cytometer to enhance research and training in the South Carolina Upstate. Flow cytometry is a powerful tool for the simultaneous analysis of multiple biological and/or chemical targets within cells or similarly sized objects. It possesses the speed, sensitivity, and robustness to analyze rare populations within large, heterogeneous samples, making it a critical analytical tool that will be used in faculty-led, student-centered research in the Biology, Chemistry, and Neuroscience programs at Furman, a research-active Primarily Undergraduate Institution (PUI). In addition, faculty and student research efforts at other regional PUIs will benefit from access to this equipment. Acquisition of the flow cytometer will enable the high-impact engagement of at least 50 students and faculty across the three participating institutions each year. Through multiple active NSF summer research programs, additional faculty and students from regional PUIs, HBCUs, two-year colleges, and first generation-serving institutions will directly benefit from access to the instrument. Faculty-led research programs serve as the cornerstone of Furman’s vision of engaged learning for undergraduates in the sciences. Acquisition of the flow cytometer will enable diverse research including (1) activation-induced chromatin decondensation in cells of the lymphocyte lineage; (2) polydiacetylene liposomes as sensors and imaging agents; (3) effects of reactive oxygen species fungi; (4) the development of novel PI3K inhibitors; (5) sex differences in the effects of high fat diet; (6) RNA binding proteins; and (7) stem cells biology. Faculty are committed to dissemination of their findings in presentations at national conferences and publications that include undergraduate co-authors in respected peer-reviewed journals.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.