MRI: The Acquisition of a Flow Cytometer to Enhance Research and Training at South Carolina Undergraduate Institutions in the Upstate

MRI：购买流式细胞仪以加强北部南卡罗来纳州本科机构的研究和培训

• 批准号: 2018510
• 负责人: Jason Rawlings
• 金额: $ 31.97万
• 依托单位: Furman University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018510&HistoricalAwards=false
• 关键词: MRI; Acquisition; Flow; Cytometer; Enhance

An award is made to Furman University to support the acquisition of a flow cytometer to enhance research and training in the South Carolina Upstate. Flow cytometry is a powerful tool for the simultaneous analysis of multiple biological and/or chemical targets within cells or similarly sized objects. It possesses the speed, sensitivity, and robustness to analyze rare populations within large, heterogeneous samples, making it a critical analytical tool that will be used in faculty-led, student-centered research in the Biology, Chemistry, and Neuroscience programs at Furman, a research-active Primarily Undergraduate Institution (PUI). In addition, faculty and student research efforts at other regional PUIs will benefit from access to this equipment. Acquisition of the flow cytometer will enable the high-impact engagement of at least 50 students and faculty across the three participating institutions each year. Through multiple active NSF summer research programs, additional faculty and students from regional PUIs, HBCUs, two-year colleges, and first generation-serving institutions will directly benefit from access to the instrument. Faculty-led research programs serve as the cornerstone of Furman’s vision of engaged learning for undergraduates in the sciences. Acquisition of the flow cytometer will enable diverse research including (1) activation-induced chromatin decondensation in cells of the lymphocyte lineage; (2) polydiacetylene liposomes as sensors and imaging agents; (3) effects of reactive oxygen species fungi; (4) the development of novel PI3K inhibitors; (5) sex differences in the effects of high fat diet; (6) RNA binding proteins; and (7) stem cells biology. Faculty are committed to dissemination of their findings in presentations at national conferences and publications that include undergraduate co-authors in respected peer-reviewed journals.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

福曼大学被授予一项支持购买流式细胞仪的奖项，以加强南卡罗来纳州北部的研究和培训。流式细胞术是同时分析细胞或类似大小物体内多个生物和/或化学目标的强大工具。它具有在大型、异质样本中分析稀有种群的速度、灵敏度和稳健性，使其成为一种关键的分析工具，将用于福尔曼生物、化学和神经科学项目中由教师领导、以学生为中心的研究，福尔曼是一个研究活跃的主要本科生机构(PUI)。此外，其他地区PUI的教职员工和学生的研究工作也将受益于使用这种设备。购买流式细胞仪将使三个参与机构每年至少有50名学生和教职员工参与到高影响力的活动中。通过多个活跃的NSF暑期研究项目，来自地区PUI、HBCU、两年制学院和第一代服务机构的更多教职员工和学生将直接受益于该仪器的使用。教师主导的研究项目是福曼为理科本科生提供参与式学习的愿景的基石。获得流式细胞仪将使多种研究成为可能，包括(1)激活诱导淋巴细胞系细胞染色质解缩；(2)作为传感器和成像剂的聚二乙炔脂质体；(3)活性氧对真菌的影响；(4)新型PI3K抑制剂的开发；(5)高脂饮食影响的性别差异；(6)RNA结合蛋白；(7)干细胞生物学。教师们致力于在国家会议和出版物上发表演讲来传播他们的发现，其中包括在受人尊敬的同行评议期刊上的本科生合著者。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。