MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Enhance Research and Training at Skidmore College

该奖项由主要研究仪器和化学研究仪器计划支持。斯基德莫尔学院正在购买一台配备自动换样器的400 MHz核磁共振（NMR）光谱仪，以支持Steven Frey教授及其同事Raymond Giguere、Juan Navea、奥雷利亚Ball和安娜Brezny。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及允许研究生物相关物种。一般来说，NMR光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器是该机构和附近的州立大学纽约阿迪朗达克社区学院化学和生物化学本科生教学、研究和研究培训的一个组成部分。授予NMR光谱仪的目的是加强各级的研究和教育。它特别影响合成锰（II）配合物用作超氧化物歧化酶的模拟物的表征。该仪器还用于表征和调节小蛋白同源性3（SH3）结构域结合途径生物物理学。此外，它有利于有机电化学机理研究方法的发展和探索有机合成的重点是分子内环加成。该光谱仪还用于研究pH值在大气相关光敏剂的水溶液光化学中的作用。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Skidmore College is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer equipped with an automatic sample changer to support Professor Steven Frey and colleagues Raymond Giguere, Juan Navea, Aurelia Ball and Anna Brezny. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution and at nearby State University of New York Adirondack Community College.The award of an NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts the characterization of synthesized manganese(II) complexes used as mimics for superoxide dismutase. The instrumentation is also used for characterizing and modulating the small protein homology 3 (SH3) domain binding pathway biophysics. In addition, it benefits the development of methodology for mechanistic studies in organic electrochemistry and for exploring organic synthesis focusing on intramolecular cycloadditions. The spectrometer is also used for studying the role of pH in the aqueous photochemistry of atmospherically-relevant photosensitizers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.