The resting state of B lymphocytes and their Transition into early and late activation stages (02)

02项目研究静息B淋巴细胞表面受体的纳米级组织。我们发现在这些细胞上，IgM类和IGD类的B细胞抗原受体定位于不同的受体纳米簇中，并且四跨膜蛋白CD20是IGD类纳米结构域的关键守门人。在新的资助期，我们想要更多地了解CD20的把关功能，B细胞如何退出静息状态，并研究调控没有CD20的Ramos B细胞从B细胞到浆细胞发育的关键调控电路。

The project 02 studies the nanoscale organization of receptors on the surface of resting B lymphocytes. We found that on these cells the B cell antigen receptors of class IgM and IgD are localized inside distinct receptor nanocluster and that the tetraspanning membrane protein CD20 is a critical gatekeeper for the IgD class nanodomain. In the new funding period, we want to learn more about the CD20 gatekeeper function, how B cells exit the resting state and study critical regulatory circuits that regulate the B-cell to plasma cell development of Ramos B cells without CD20.