RAPID: Plasmonically-enhanced Detection of Corona Virus Disease (COVID-19)

RAPID:冠状病毒病 (COVID-19) 的等离激元增强检测

基本信息

  • 批准号:
    2027145
  • 负责人:
  • 金额:
    $ 10万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-04-15 至 2021-09-30
  • 项目状态:
    已结题

项目摘要

Coronavirus Disease 2019 (COVID-19) is a highly contagious, pandemic disease that has rapidly spread to several hundred thousand people worldwide and caused many deaths. To facilitate the surveillance and control of the spread of the virus, Prof. Singamaneni of Washington University at St. Louis aims to develop a rapid and low-cost diagnostic method that can detect infection in individuals that are asymptomatic or exhibiting mild symptoms. The sensitive biosensing method is designed to rapidly assess the immune response to the coronavirus across a large population in a high-throughput manner and to enable understanding of the epidemiology of the highly contagious disease. The novel biosensor is suitable for point-of-care and resource-limited settings and can be easily adapted to a broad range of public health threats. This research project provides opportunities to graduate students to be trained in sensor design and the study of sensor performance. The aim of this project is to design and realize a dual-modal lateral flow assay for highly sensitive and specific detection of IgG and IgM antibodies to coronavirus (SARS-CoV-2) using plasmon-enhanced fluorescence. Specifically, the dual-modal lateral flow assay relies on plasmonic-fluor, an ultrabright fluorescent nanostructure, to achieve high sensitivity and low detection limit. In addition to ultrabright fluorescence signal, plasmonic-fluors exhibit large absorption and scattering cross-section, making them attractive labels that can be directly visualized by naked eye at high target concentrations. This dual-modal lateral flow assay enables simultaneous detection of relatively high concentrations of the antibodies as a simple colorimetric signal and low concentrations of the antibodies through highly sensitive fluorescence signal.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
2019冠状病毒病(COVID-19)是一种高度传染性的大流行疾病,已迅速蔓延至全球数十万人,并造成许多人死亡。为了促进对病毒传播的监测和控制,圣路易斯华盛顿大学的Singamaneni教授的目标是开发一种快速和低成本的诊断方法,可以在无症状或表现出轻微症状的个体中检测到感染。灵敏的生物传感方法旨在以高通量的方式快速评估大量人群对冠状病毒的免疫反应,并使人们能够了解这种高传染性疾病的流行病学。这种新型生物传感器适用于护理点和资源有限的环境,可以很容易地适应广泛的公共卫生威胁。本研究计画提供机会,让研究生在感测器设计及感测器性能的研究方面得到训练。本项目旨在设计并实现一种双模态横向流动检测方法,用于高灵敏度和特异性检测冠状病毒(SARS-CoV-2) IgG和IgM抗体。具体来说,双峰侧流分析依赖于等离子体荧光,一种超亮的荧光纳米结构,以实现高灵敏度和低检测限。除了超亮的荧光信号外,等离子体荧光还表现出大的吸收和散射截面,使它们成为有吸引力的标签,可以在高目标浓度下用肉眼直接观察到。这种双模态横向流动试验可以同时检测相对高浓度的抗体作为简单的比色信号和低浓度的抗体通过高度敏感的荧光信号。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Srikanth Singamaneni其他文献

Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cell–extracellular matrix mechanical feedback
张力各向异性通过自我强化的细胞-细胞外基质机械反馈驱动成纤维细胞表型转变
  • DOI:
    10.1038/s41563-025-02162-5
  • 发表时间:
    2025-03-24
  • 期刊:
  • 影响因子:
    38.500
  • 作者:
    Farid Alisafaei;Delaram Shakiba;Yuan Hong;Ghiska Ramahdita;Yuxuan Huang;Leanne E. Iannucci;Matthew D. Davidson;Mohammad Jafari;Jin Qian;Chengqing Qu;David Ju;Dashiell R. Flory;Yin-Yuan Huang;Prashant Gupta;Shumeng Jiang;Aliza Mujahid;Srikanth Singamaneni;Kenneth M. Pryse;Pen-hsiu Grace Chao;Jason A. Burdick;Spencer P. Lake;Elliot L. Elson;Nathaniel Huebsch;Vivek B. Shenoy;Guy M. Genin
  • 通讯作者:
    Guy M. Genin
Deposition of parallel arrays of palladium nanowires and electrical characterization using microelectrode contacts
钯纳米线平行阵列的沉积和使用微电极接触的电学表征
  • DOI:
    10.1088/0957-4484/15/3/025
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Massood Z Atashbar;Deep Banerji;Srikanth Singamaneni;Valery Bliznyuk
  • 通讯作者:
    Valery Bliznyuk

Srikanth Singamaneni的其他文献

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{{ truncateString('Srikanth Singamaneni', 18)}}的其他基金

Understanding Fundamental Mechanisms that Underlie Nano-Neuro Interactions
了解纳米神经相互作用的基本机制
  • 批准号:
    2331330
  • 财政年份:
    2024
  • 资助金额:
    $ 10万
  • 项目类别:
    Standard Grant
Plasmon-enhanced Expansion FluoroSpot for Imaging and Quantifying Single Cell Protein Secretion
用于单细胞蛋白质分泌成像和定量的等离激元增强扩增 FluoroSpot
  • 批准号:
    2316285
  • 财政年份:
    2023
  • 资助金额:
    $ 10万
  • 项目类别:
    Standard Grant
Plasmon-enhanced Lateral Flow Assay for Multiplexed Detection of SARS-CoV-2 RNA and Antigens in Point-of-Care Settings
等离激元增强侧流分析用于在护理点环境中多重检测 SARS-CoV-2 RNA 和抗原
  • 批准号:
    2224610
  • 财政年份:
    2022
  • 资助金额:
    $ 10万
  • 项目类别:
    Standard Grant
CAREER: Plasmonic Nanoclusters with Built-in Artificial Antibodies for Label-free Biosensing
职业:具有内置人工抗体的等离激元纳米簇,用于无标记生物传感
  • 批准号:
    1254399
  • 财政年份:
    2013
  • 资助金额:
    $ 10万
  • 项目类别:
    Continuing Grant

相似海外基金

Plasmonically Enhanced Point-of-care Detection of Cardiac Biomarkers by a Smart Phone
通过智能手机对心脏生物标志物进行等离子体增强即时检测
  • 批准号:
    10570910
  • 财政年份:
    2019
  • 资助金额:
    $ 10万
  • 项目类别:
Plasmonically Enhanced Point-of-care Detection of Cardiac Biomarkers by a Smart Phone
通过智能手机对心脏生物标志物进行等离子体增强即时检测
  • 批准号:
    10358496
  • 财政年份:
    2019
  • 资助金额:
    $ 10万
  • 项目类别:
Novel microcantilever sensor using plasmonically enhanced nonlinearity
利用等离子体增强非线性的新型微悬臂梁传感器
  • 批准号:
    1809891
  • 财政年份:
    2018
  • 资助金额:
    $ 10万
  • 项目类别:
    Standard Grant
Plasmonically Enhanced Light Harvesting in Quantum Dot Solar Cells
量子点太阳能电池中的等离子体增强光收集
  • 批准号:
    470561-2015
  • 财政年份:
    2018
  • 资助金额:
    $ 10万
  • 项目类别:
    Postdoctoral Fellowships
Plasmonically enhanced production and amplified emission of singlet oxygen
等离子体增强单线态氧的产生和放大发射
  • 批准号:
    510623-2017
  • 财政年份:
    2017
  • 资助金额:
    $ 10万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Master's
Plasmonically Enhanced Stimulated Coherent Spectroscopy
等离子体增强受激相干光谱
  • 批准号:
    1609952
  • 财政年份:
    2016
  • 资助金额:
    $ 10万
  • 项目类别:
    Standard Grant
Plasmonically Enhanced Light Harvesting in Quantum Dot Solar Cells
量子点太阳能电池中的等离子体增强光收集
  • 批准号:
    470561-2015
  • 财政年份:
    2015
  • 资助金额:
    $ 10万
  • 项目类别:
    Postdoctoral Fellowships
Plasmonically enhanced optical ring resonators for label-free single molecule detection
用于无标记单分子检测的等离子增强光学环形谐振器
  • 批准号:
    1303499
  • 财政年份:
    2013
  • 资助金额:
    $ 10万
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    Standard Grant
Theory of electro-optic and chiral coupling in plasmonically enhanced HIOS (B10)
等离子体增强 HIOS 中的电光和手性耦合理论 (B10)
  • 批准号:
    236821898
  • 财政年份:
    2013
  • 资助金额:
    $ 10万
  • 项目类别:
    Collaborative Research Centres
GOALI: Plasmonically Enhanced Bulk Heterojunction Organic Photovoltaics
目标:等离激元增强体异质结有机光伏
  • 批准号:
    1202465
  • 财政年份:
    2012
  • 资助金额:
    $ 10万
  • 项目类别:
    Continuing Grant
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