NSF Convergence Accelerator Track C: High-Throughput Proteomics Technology Based on Quantum Sensing

NSF融合加速器轨道C：基于量子传感的高通量蛋白质组学技术

• 批准号: 2040520
• 负责人: Peter Maurer
• 金额: $ 100万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2040520&HistoricalAwards=false
• 关键词: NSF; Convergence; Accelerator; Track; Throughput

The NSF Convergence Accelerator supports use-inspired, team-based, multidisciplinary efforts that address challenges of national importance and will produce deliverables of value to society in the near future. The research outcomes from this project will pave the way to establish quantum technology as a critical tool in biomedicine, and specifically for proteomic devices. Proteomic devices are used to map the protein profile of a given cell, tissue, and or/organism. The information can be used in turn to develop treatment for disease. This project will show how novel discoveries in quantum sensing can impact and alter diagnostics and biomedical research. This will be accomplished by simplifying the purification process and enabling high throughput screening at reduced cost. The core concept is focused on the discovery of exceptional sensitivity of nitrogen vacancy (NV) color centers in diamond.The project will bring together quantum physicists, engineers, and experts in life sciences to work on a real world application of quantum sensing. This project will demonstrate scaled up profiling of 7000+ proteins. There are three main thrusts, which include: i) the development of an aptamer binding assay on a diamond surface, ii) identification for optically stable reporter spins, and iii) site-specific conjugation of spin labels for sensing protein binding events. If successful, this will lead to a new generation of proteomic devices. Opportunities for training and workforce development include: industry and National Lab experience for PhD students, ii) workshops and certificate programs for industry researchers and engineers, and iii) outreach programs for K-12 students to learn about quantum technology and its potential impact on daily life.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

NSF融合加速器支持以使用为灵感，以团队为基础，多学科的努力，以应对国家重要性的挑战，并将在不久的将来为社会提供有价值的成果。 该项目的研究成果将为建立量子技术作为生物医学的关键工具铺平道路，特别是蛋白质组学设备。 蛋白质组学装置用于绘制给定细胞、组织和/或生物体的蛋白质图谱。 这些信息可以反过来用于开发疾病的治疗方法。 该项目将展示量子传感的新发现如何影响和改变诊断和生物医学研究。 这将通过简化纯化过程并以降低的成本实现高通量筛选来实现。核心概念集中在发现金刚石中氮空位（NV）色心的异常灵敏度。该项目将汇集量子物理学家、工程师和生命科学专家，致力于量子传感的真实的世界应用。 该项目将展示7000多个蛋白质的放大谱。有三个主要的推动力，包括：i）在金刚石表面上开发适体结合测定，ii）鉴定光学稳定的报告子自旋，以及iii）用于感测蛋白质结合事件的自旋标记的位点特异性缀合。 如果成功，这将导致新一代的蛋白质组学设备。 培训和劳动力发展的机会包括：博士生的行业和国家实验室经验，ii）行业研究人员和工程师的研讨会和证书课程，和iii）为K-12名学生了解量子技术及其对日常生活的潜在影响。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值进行评估，被认为值得支持和更广泛的影响审查标准。

项目成果

Preparation of metrological states in dipolar-interacting spin systems

• DOI: 10.1038/s41534-022-00667-4
• 发表时间: 2022-03
• 期刊: npj Quantum Information
• 影响因子: 7.6
• 作者: Tian-Xing Zheng;Anran Li;Jude Rosen;Sisi Zhou;M. Koppenhöfer;Ziqi Ma;F. Chong;A. Clerk

Ultrahigh nitrogen-vacancy center concentration in diamond

• DOI: 10.1016/j.carbon.2021.12.032
• 发表时间: 2021-10
• 期刊: Carbon
• 影响因子: 10.9
• 作者: S. Kollarics;F. Simon;A. Bojtor;K. Koltai;G. Klujber;M. Szieberth;B. G. M'arkus;D. Beke;K. Kamar'as;Á. Gali;D. Amirari;R. Berry;S. Boucher;D. Gavryushkin;G. Jeschke;J. P. Cleveland;S. Takahashi;P. Szirmai;L. Forr'o;E. Emmanouilidou;R. Singh;K. Holczer