I-Corps: Low-cost photothermal nanosensors for quantitative biomarker detection using a thermometer

I-Corps：使用温度计进行定量生物标志物检测的低成本光热纳米传感器

• 批准号: 2052347
• 负责人: XiuJun Li
• 金额: $ 5万
• 依托单位: University of Texas at El Paso
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2023-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2052347&HistoricalAwards=false
• 关键词: Corps; Low; cost; photothermal; nanosensors

The broader impact/commercial potential of this I-Corps project is the development of new, low-cost, portable biomarker detection methods in response to the growing market of biomolecular detectors for various applications such as disease diagnosis and cancer biomarker detection at the point of care. For example, prostate cancer is the second leading cause of cancer death in men in the United States. It is estimated that 191,930 new cases and 33,330 deaths from this disease will occur this year. However, the current technologies for prostate cancer diagnosis are invasive, and require expensive instrumentation, which significantly impairs their capacity for point-of-care (POC) detection in low-resource settings such as physician’s offices or at a patient’s bedside. The proposed photothermal nanobiosensor uses a thermometer for quantitative biosensing. The nanobiosensor is rapid, low-cost, minimally invasive, and does not require expensive equipment and trained personnel for data recording and processing; This may enable prostate-specific antigen (PSA, a prostate cancer biomarker) testing in small physician’s offices. The thermometer-based nanobiosensor also may be used to detect a variety of other disease biomarkers and biochemicals.This I-Corps project is based on the development of the thermometer-based nanosensor for point-of-care (POC) detection of biomarkers such as the prostate-specific antigen (PSA). The innovation is based on a biosensing method using a thermometer as the signal reader. The thermometer-based nanobiosensor is not only rapid, low-cost, and portable, but also minimizes instrumentation requirements. In addition, the nanobiosensor offers comparable detection sensitivity to conventional immunoassay methods. The proposed photothermal immunosensor may open up new opportunities for affordable detection of disease biomarkers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是开发新的、低成本的、便携式生物标志物检测方法，以响应用于各种应用的生物分子检测器的不断增长的市场，例如疾病诊断和癌症生物标志物检测。例如，前列腺癌是美国男性癌症死亡的第二大原因。据估计，今年将有191，930例新病例和33，330例死亡。然而，目前用于前列腺癌诊断的技术是侵入性的，并且需要昂贵的仪器，这显著损害了它们在诸如医生办公室或患者床边的低资源环境中进行即时（POC）检测的能力。所提出的光热纳米生物传感器使用温度计进行定量生物传感。 纳米生物传感器是快速的，低成本的，微创的，并且不需要昂贵的设备和训练有素的人员进行数据记录和处理;这可以使前列腺特异性抗原（PSA，前列腺癌生物标志物）测试在小医生的办公室。 基于温度计的纳米生物传感器也可用于检测各种其他疾病的生物标志物和生化物质。I-Corps项目基于基于温度计的纳米传感器的开发，用于护理点（POC）检测生物标志物，如前列腺特异性抗原（PSA）。该创新基于使用温度计作为信号读取器的生物传感方法。基于温度计的纳米生物传感器不仅快速，低成本和便携式，而且还最大限度地减少了仪器要求。此外，纳米生物传感器提供了与传统免疫测定方法相当的检测灵敏度。该奖项反映了NSF的法定使命，并已被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

项目成果

Facile Synthesis and Integration of Poly(vinyl alcohol) Sponge-Supported Metal Nanocatalysts on a Microfluidic Chip Enable a New Continuous Flow Multireactor Nanocatalysis Platform for High Efficiency and Reusability Catalysis

• DOI: 10.1021/acssuschemeng.2c02060
• 发表时间: 2022-07-29
• 期刊: ACS SUSTAINABLE CHEMISTRY & ENGINEERING
• 影响因子: 8.4
• 作者: Hu, Kaiqiang;Ma, Lei;Li, XiuJun
• 通讯作者: Li, XiuJun

Detector-Free Photothermal Bar-Chart Microfluidic Chips (PT-Chips) for Visual Quantitative Detection of Biomarkers

用于生物标志物视觉定量检测的无探测器光热条形图微流控芯片 (PT-Chips)

• DOI: 10.1021/acs.analchem.1c01323
• 发表时间: 2021
• 期刊: Analytical Chemistry
• 影响因子: 7.4
• 作者: Zhou, Wan;Fu, Guanglei;Li, Xiujun
• 通讯作者: Li, Xiujun