I-Corps: Ultra-Fast COVID-19 Sensor

I-Corps：超快速 COVID-19 传感器

• 批准号: 2052574
• 负责人: Gerardine Botte
• 金额: $ 5万
• 依托单位: Texas Tech University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2052574&HistoricalAwards=false
• 关键词: Corps; Ultra; Fast; COVID; 19

The broader impact/commercial potential of this I-Corps project include the deployment of a diagnostic sensor at the COVID-19 pandemic frontlines such as hospitals, clinical laboratories, authorized drive-in labs, airports, and public spaces like supermarkets, schools, and universities, work spaces. The sensor will be used for ultra-fast (less than 1 minute) non-invasive screening of samples to ensure safety. The ultimate goal is a home-based test that minimizes the exposure and transmission of virus to clinical technicians and others at testing locations. This testing ability will identify and isolate carriers of the virus and thereby control the spread of virus. This technology is timely to counter COVID-19; However, it can be extended towards detecting other bacteria and viruses and has shown promise for detecting HIV as well. The versatility of the sensor will be investigated. In general, the innovation may lead to ensuring the healthcare of the population by monitoring the condition of individuals rapidly without causing discomfort. This I-Corps project focuses on a new technology for COVID-19 diagnosis. The ultra-fast COVID-19 (UFC-19) detection sensor is a fast, portable, small size instrument that operates directly with saliva (it does not require special swabs or collection devices) for COVID-19 diagnosis with the ability to sense the presence/absence of the virus SARS-CoV-2 in a sample in less than 1 second. The portability and the speed of results makes this sensor a potentially important diagnostic tool for fast initial screening of samples and continuous monitoring of an individual. The UFC-19 technology is based on the electron transfer reaction between the proteins present in the SARS-CoV-2 virus at the electrode/electrolyte interface. This innovation advances the current understanding of electrochemical sensors for point-of-care applications by utilizing multidisciplinary contributions from electrochemical engineering, virology, and physiology, among others. Through this I-Corps program, the team intends to learn about the proposed market to pave the path for commercializing the sensor.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目的更广泛影响/商业潜力包括在 COVID-19 大流行前线部署诊断传感器，例如医院、临床实验室、授权的汽车实验室、机场以及超市、学校和大学等公共场所、工作场所。 该传感器将用于对样本进行超快速（小于1分钟）无创筛查，以确保安全。最终目标是进行家庭测试，最大限度地减少病毒对临床技术人员和测试地点其他人员的接触和传播。这种检测能力将识别和隔离病毒携带者，从而控制病毒的传播。这项技术对于对抗 COVID-19 来说是及时的；然而，它可以扩展到检测其他细菌和病毒，并且也显示出检测艾滋病毒的前景。将研究传感器的多功能性。总的来说，这项创新可以通过快速监测个人状况而不会造成不适，从而确保民众的医疗保健。该 I-Corps 项目重点关注用于 COVID-19 诊断的新技术。超快速 COVID-19 (UFC-19) 检测传感器是一种快速、便携式、小型仪器，可直接使用唾液（不需要特殊的拭子或采集设备）进行 COVID-19 诊断，能够在不到 1 秒的时间内感测样本中是否存在病毒 SARS-CoV-2。 便携性和结果速度使该传感器成为潜在的重要诊断工具，可用于快速初步筛选样本和持续监测个体。 UFC-19技术基于SARS-CoV-2病毒中存在于电极/电解质界面的蛋白质之间的电子转移反应。这项创新利用电化学工程、病毒学和生理学等多学科的贡献，增进了目前对用于即时护理应用的电化学传感器的理解。通过这个 I-Corps 计划，该团队打算了解拟议的市场，为传感器的商业化铺平道路。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。