Development of High-performing Nanoplasmonic Biosensors with Novel Thin Films and Metasurfaces

开发具有新型薄膜和超表面的高性能纳米等离子体生物传感器

• 批准号: 2109042
• 负责人: Quan Cheng
• 金额: $ 45.6万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2109042&HistoricalAwards=false
• 关键词: Development; performing; Nanoplasmonic; Biosensors; Novel

With the support of the Chemical Measurement and Imaging (CMI) Program in the Division of Chemistry, Professor Quan Cheng and his group at the University of California-Riverside are working to develop new optical biosensors to improve molecular sensing of proteins and small molecules via methods that do not require chemical changes to the targets being sensed. These new approaches are based on use of metals structured in a way at the nanometer scale so that light of a given energy generates waves of electrons on the surface of the metals, with the energy being impacted by the presence of molecules near the surface of the sensor. These nanoplasmonic sensors are anticipated to offer new avenues for detection of small molecules that could not be achieved previously, potentially leading to significantly improved detection of biological molecules in the longer term. Such sensing methods are needed for a wide range of applications, including for medical diagnostics, for food/water safety monitoring, and for drug discovery. The Cheng group will focus their research efforts on generating plasmonic substrates with aluminum instead of traditional metals such as gold or silver. This approach has a number of potential advantages, including better performance, lower cost, high sustainability, and long-term environmental benefit. The highly interdisciplinary nature of the project offers opportunities for students to gain broad experience in surface chemistry, materials science, biology, and bioanalytical chemistry. In this work, Professor Cheng and his group are working with emerging plasmonic materials in thin film and nanostructured, meta-surface formats. Methodologies are designed to achieve high detection sensitivity with aluminum films in the Kretschmann configuration and build new surface chemistry allowing convenient functionalization of the interface. The core technical innovation of this project is in developing aluminum plasmonic applications, with the intrinsic plasmonic properties leveraged into improvements in the capacity of several analytical techniques including surface plasmon resonance (SPR), SPR imaging (SPRi), and terahertz (THz) sensing. New strategies will be developed to eliminate technical barriers that have limited application of aluminum, and THz sensing with aluminum metasurfaces will be demonstrated for the characterization of inter- and intra-molecular, weak bonding networks. Finally, a novel biosensor with indium plasmonic arrays and SPR imaging is being developed. The exploration of indium thin films could offer new substrates for label-free detection and provide a tactic to mitigate against limitations associated with oxide coatings.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学测量和成像（CMI）项目的支持下，加州大学河滨分校的Quan Cheng教授和他的团队正在努力开发新的光学生物传感器，以通过不需要化学变化的方法来改善蛋白质和小分子的分子传感。 这些新方法基于使用以纳米尺度的方式构造的金属，使得给定能量的光在金属表面上产生电子波，其中能量受到传感器表面附近分子的存在的影响。 这些纳米等离子体传感器预计将为检测以前无法实现的小分子提供新的途径，从长远来看，可能会显着改善对生物分子的检测。 这样的传感方法是广泛的应用所需要的，包括用于医学诊断、用于食品/水安全监测以及用于药物发现。 Cheng小组将把研究重点放在用铝代替金或银等传统金属来产生等离子体基片上。 这种方法具有许多潜在的优势，包括更好的性能，更低的成本，高可持续性和长期的环境效益。 该项目的高度跨学科性质为学生提供了在表面化学，材料科学，生物学和生物分析化学方面获得广泛经验的机会。在这项工作中，Cheng教授和他的团队正在研究薄膜和纳米结构的元表面形式的新兴等离子体材料。 方法的设计，以实现高检测灵敏度与铝膜的Kretschmann配置和建立新的表面化学允许方便的功能化的接口。 该项目的核心技术创新是开发铝等离子体应用，利用固有的等离子体特性来提高几种分析技术的能力，包括表面等离子体共振（SPR），SPR成像（SPRi）和太赫兹（THz）传感。 将开发新的策略来消除限制铝应用的技术障碍，并将展示铝超颖表面的THz传感，用于表征分子间和分子内的弱键合网络。 最后，一种新型的生物传感器与铟等离子体阵列和SPR成像正在开发中。 对铟薄膜的探索可以为无标签检测提供新的基底，并提供一种策略，以减轻与氧化物涂层相关的限制。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Surface plasmon resonance imaging (SPRi) in combination with machine learning for microarray analysis of multiple sclerosis biomarkers in whole serum

• DOI: 10.1016/j.biosx.2022.100127
• 发表时间: 2022-05
• 期刊: Biosensors and Bioelectronics: X
• 作者: Alexander S. Malinick;Daniel D. Stuart;Alexander S. Lambert;Q. Cheng

Biosensing empowered by molecular identification: Advances in surface plasmon resonance techniques coupled with mass spectrometry and Raman spectroscopy

• DOI: 10.1016/j.snr.2022.100129
• 发表时间: 2022-11-20
• 期刊: SENSORS AND ACTUATORS REPORTS
• 影响因子: 5.9
• 作者: Stuart，Daniel D.;Ebel，Cole P.;Cheng，Quan
• 通讯作者: Cheng，Quan

Plasmon-Enhanced Fluorescence in Electrospun Nanofibers of Polydiacetylenes Infused with Silver Nanoparticles

• DOI: 10.1021/acs.langmuir.1c02805
• 发表时间: 2021-12-14
• 期刊: LANGMUIR
• 影响因子: 3.9
• 作者: Burris, Andrew J.;Cheng, Quan
• 通讯作者: Cheng, Quan