SENSORS: Developing Waveguide Surface Plasmon Resonance Imaging Spectroscopy for Membrane Proteins

传感器：开发膜蛋白波导表面等离子共振成像光谱

• 批准号: 0428908
• 负责人: Quan Cheng
• 金额: $ 36.55万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0428908&HistoricalAwards=false
• 关键词: SENSORS; Developing; Waveguide; Surface; Plasmon

0428908ChengThis project will specifically develop a new imaging SPR technique for microarray analysis of membrane proteins without radioactive or fluorescent labels. The proposed waveguide surface plasmon resonance imaging spectroscopy will retain the intrinsic high detection sensitivity and label-free detection already available in the current SPR technique. The new technique allows characterization of anisotropic properties of the sensing interface, giving insight into structural changes of biological membranes and membrane bound proteins upon activation.

这个项目将专门开发一种新的成像SPR技术，用于无放射性或荧光标记的膜蛋白微阵列分析。所提出的波导表面等离子体共振成像光谱学将保留现有SPR技术中固有的高检测灵敏度和无标记检测。这项新技术允许表征传感界面的各向异性属性，从而深入了解生物膜和膜结合蛋白在激活时的结构变化。