MRI: Acquisition of an NMR console and probe to support research and education

MRI：购买 NMR 控制台和探头以支持研究和教育

• 批准号: 2116395
• 负责人: Robert Williamson
• 金额: $ 50万
• 依托单位: University of North Carolina at Wilmington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2116395&HistoricalAwards=false
• 关键词: MRI; Acquisition; NMR; console; probe

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of North Carolina at Wilmington (UNCW) is upgrading the electronics of a console for a 500 MHz nuclear magnetic resonance (NMR) spectrometer and is equipping it with a modern probe to support chemistry research at UNCW. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of chemically and biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution as well as collaborators from regional colleges such as those from the University of North Carolina at Pembroke that serves a distinctly diverse student body. Students from the Pembroke’s Research Initiative for Scientific Enhancement (RISE) Program whose goal is to create a more diverse research workforce are users of this instrumentation.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts the development of methodologies to facilitate the structure elucidation of small and medium-sized molecules. The instrumentation is also used to study the chemical ecology and for structurally determining natural products from cultured microbes and harmful algal blooms. The instrument also serves researchers evaluating medicinal plant extracts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。北卡罗来纳州威尔明顿大学（UNCW）正在升级500 MHz核磁共振（NMR）光谱仪控制台的电子设备，并为其配备现代探针，以支持UNCW的化学研究。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及允许研究化学和生物学相关物种。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器是教学的一个组成部分，以及研究和本科生在化学和生物化学在这个机构的研究培训，以及从区域学院的合作者，如那些来自彭布罗克的北卡罗来纳州大学，服务于一个明显多样化的学生团体。来自彭布罗克科学增强研究倡议（RISE）计划的学生是该仪器的用户，该计划的目标是创建一个更加多样化的研究队伍。NMR光谱仪的获奖旨在加强各级的研究和教育。它特别影响了方法学的发展，以促进中小分子的结构解析。该仪器还用于研究化学生态学，并从结构上确定培养微生物和有害藻华的天然产物。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Cannabicitran: Its unexpected racemic nature and potential origins

大麻素：其意想不到的外消旋性质和潜在起源

• DOI: 10.1002/chir.23571
• 发表时间: 2023
• 期刊: Chirality
• 影响因子: 2
• 作者: Wood, Jared S.;Gordon, William H.;Morgan, Jeremy B.;Williamson, R. Thomas
• 通讯作者: Williamson, R. Thomas

Structural revision of a Wnt/β-catenin modulator and confirmation of cannabielsoin constitution and configuration

Wnt/β-连环蛋白调节剂的结构修订和大麻素组成和配置的确认

• DOI: 10.1039/d1cc01971f
• 发表时间: 2021
• 期刊: Chemical Communications
• 影响因子: 4.9
• 作者: Monroe, Angelina Z.;Gordon, William H.;Wood, Jared S.;Martin, Gary E.;Morgan, Jeremy B.;Williamson, R. Thomas
• 通讯作者: Williamson, R. Thomas

Myrica cerifera, a Medicinal Plant of the Lumbee Tribe, has Antibacterial and Nematicidal Properties.

• DOI: 10.33697/ajur.2022.054
• 发表时间: 2022-06
• 期刊: American journal of undergraduate research
• 作者: Edwards, Ashley;Deberry, Kazhmiri;Mariani, Hannah;Taylor, Darian H;Cochran, Nicholas J;Barrios Sosa, Ana C;Scott, Andrea Regan;Williamson, R Thomas;Tirla, Cornelia;Sandefur, Conner;Alexander, Courtney Carroll
• 通讯作者: Alexander, Courtney Carroll

Prediction of anisotropic NMR data without knowledge of alignment medium structure by surface decomposition

在不了解排列介质结构的情况下通过表面分解预测各向异性 NMR 数据

• DOI: 10.1039/d2cp02621j
• 发表时间: 2022
• 期刊: Physical Chemistry Chemical Physics
• 影响因子: 3.3
• 作者: Liu, Yizhou;Ndukwe, Ikenna E.;Reibarkh, Mikhail;Martin, Gary E.;Williamson, R. Thomas
• 通讯作者: Williamson, R. Thomas

Calculated and experimental 1 H and 13 C NMR assignments for cannabicitran

大麻素的计算和实验 1 H 和 13 C NMR 归属

• DOI: 10.1002/mrc.5224
• 发表时间: 2021
• 期刊: Magnetic Resonance in Chemistry
• 影响因子: 2
• 作者: Wood, Jared S.;Gordon, William H.;Morgan, Jeremy B.;Williamson, R. Thomas
• 通讯作者: Williamson, R. Thomas