Developing Modern Spatial and Shape Analysis for New Heterogeneous High-dimensional Geospatial Data

为新的异构高维地理空间数据开发现代空间和形状分析

• 批准号: 2210912
• 负责人: Qiwei Li
• 金额: $ 20万
• 依托单位: University of Texas at Dallas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2210912&HistoricalAwards=false
• 关键词: Developing; Modern; Spatial; Shape; Analysis

Modern data science involves more and more heterogeneous geospatial data where the features of objects are measured as discrete variables. The quantification of spatial correlation of qualitative marks has been a longstanding focus in spatial statistics. It is a key aspect of population forestry and ecology theory but receives little attention in biomedicine. Recent developments in deep learning and biotechnology have greatly facilitated generating massive high-dimensional genome sequence count data with spatial information. This creates an urgent need for innovation to analyze such complex data, driving the methodological modernization and theoretical developments in spatial statistics. In this project, the investigator will develop a series of computationally efficient spatial and shape methods that are theoretically sound and practically useful for addressing the heterogeneity issue commonly seen in the new geospatial data (e.g., spatial transcriptomics data). The investigator also plans to develop user-friendly and open-source software. The project will expose undergraduate and graduate students to advanced science, technology, engineering, and mathematical skillsets.The investigator will develop three modeling frameworks to analyze heterogeneous geospatial data at different spatial resolutions. First, an energy-based framework that characterizes heterogeneous spatial patterns for both grided and point data will be developed. Compared with the traditional kernel-based methods, the new method is more robust to noise and computationally more efficient. Towards the goal, the investigator will incorporate a novel feature selection mechanism into the framework to jointly identify multiple spatial patterns for the high-dimensional geospatial data. Then, the study will explore how to construct an interpretable low-dimensional representation of the geospatial data. In particular, the investigator will focus on integrating multi-modal geospatial data to improve the accuracy and resolution of spatial domain partition. Once the spatial domains have been segmented, an immediate task is to characterize their complex shapes. Finally, a landmark-based framework that quantifies a spatial domain’s boundary will be studied to account for heterogeneous boundary roughness. The developed methodologies will contribute to much-needed theories and applications in Bayesian spatial and shape analysis. The investigator will also study the potential benefits and shortcomings of parametric and nonparametric Bayesian methods in this context from both theoretical and computational aspects. Results will be disseminated through workshops, publications, and new courses.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

现代数据科学涉及越来越多的异构地理空间数据，其中对象的特征被测量为离散变量。定性标记空间相关性的量化一直是空间统计学的研究热点。它是种群林业和生态学理论的一个重要方面，但在生物医学中很少受到关注。深度学习和生物技术的最新发展极大地促进了利用空间信息生成大量高维基因组序列计数数据。这就迫切需要创新来分析如此复杂的数据，推动空间统计的方法现代化和理论发展。在这个项目中，研究人员将开发一系列计算效率高的空间和形状方法，这些方法在理论上是合理的，在解决新的地理空间数据中常见的异质性问题（例如，空间转录组学数据）。调查员还计划开发方便用户的开放源码软件。该项目将使本科生和研究生接触到先进的科学，技术，工程和数学技能。研究人员将开发三个建模框架，以分析不同空间分辨率的异构地理空间数据。首先，将开发一个以能量为基础的框架，该框架描述网格数据和点数据的异构空间模式。与传统的基于核的方法相比，新方法对噪声具有更好的鲁棒性，计算效率更高。为了实现这一目标，研究人员将把一个新的特征选择机制纳入框架，以联合识别高维地理空间数据的多种空间模式。然后，研究将探讨如何构建一个可解释的低维表示的地理空间数据。特别是，调查员将侧重于整合多模式地理空间数据，以提高空间域划分的准确性和分辨率。一旦空间域被分割，一个直接的任务是表征其复杂的形状。最后，将研究一个基于地标的框架，量化空间域的边界，以考虑异质边界粗糙度。所开发的方法将有助于急需的理论和应用贝叶斯空间和形状分析。研究者还将从理论和计算方面研究参数和非参数贝叶斯方法在此背景下的潜在优点和缺点。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

A Bayesian modified Ising model for identifying spatially variable genes from spatial transcriptomics data

• DOI: 10.1002/sim.9530
• 发表时间: 2022-07-24
• 期刊: STATISTICS IN MEDICINE
• 影响因子: 2
• 作者: Jiang, Xi;Xiao, Guanghua;Li, Qiwei
• 通讯作者: Li, Qiwei