MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

该奖项由主要研究仪器项目和化学研究仪器项目支持。为支持肯尼斯·米勒教授及其同事：威廉·柯林斯、凯莉·科尔、艾米·莫里斯和埃里克·米勒(来自圣胡安社区学院)，刘易斯堡学院正在购置一台配备自动换样器的400 MHz核磁共振(核磁共振)光谱仪。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及对生物相关物种的研究。总体而言，核磁共振波谱是化学家研究分子结构的最强大的工具之一。核磁共振波谱被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中的运动和相互作用。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该仪器是该机构和附近的新墨西哥州圣胡安社区学院化学和生物化学本科生教学、研究和研究培训的组成部分。授予核磁共振光谱仪的目的是加强各级的研究和教育。这一仪器的获得影响了为不对称催化开发手性配体而准备的双芳醚环番构象受限产品的表征。该仪器还被用来建立一个二芳基甲烷天然产物和类似物的图书馆，可用于获得关于利什曼病的知识。此外，核磁共振谱仪还用于表征用于抗瓦楞病毒的水溶性单萜类化合物和植物树脂。最后，核磁共振光谱仪还用于表征具有潜在前药物特性和潜在碳氢活化活性的合成钴(III)配合物。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Fort Lewis College is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer equipped with an automatic sample changer to support Professor Kenneth Miller and colleagues: William Collins, Callie Cole, Aimee Morris and Eric Miller (from San Juan Community College). This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically-relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the study of the structure of molecules. NMR spectroscopy is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the motions and interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution and the nearby San Juan Community College in New Mexico. The award of an NMR spectrometer is aimed at enhancing research and education at all levels. This instrument acquisition impacts the characterization of conformationally-constrained products of diarylether cyclophanes prepared to develop chiral ligands for asymmetric catalysis. The instrumentation is also used to establish a library of diarylmethane natural products and analogues that may be used to gain knowledge on Leishmaniasis. In addition, the NMR spectrometer is used in the characterization of water solubilized monoterpenoids and plant resins used against the varroa destructor virus. Finally, the NMR spectrometer is also used to characterize synthetic cobalt(III) coordination complexes having potential prodrug properties and potential carbon-hydrogen activation activity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.