MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

该奖项由主要研究仪器和化学研究仪器计划支持。刘易斯堡学院正在购买一台配备自动换样器的400 MHz核磁共振（NMR）光谱仪，以支持肯尼斯米勒教授及其同事：威廉柯林斯、凯丽科尔、艾米莫里斯和埃里克米勒（来自圣胡安社区学院）。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及生物相关物种的研究。一般来说，NMR光谱是化学家研究分子结构的最有力的工具之一。核磁共振光谱用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间的运动和相互作用。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器是该机构和附近新墨西哥州圣胡安社区学院化学和生物化学本科生教学、研究和研究培训的一个组成部分。授予核磁共振光谱仪的目的是加强各级的研究和教育。该仪器的获得影响了制备用于开发不对称催化的手性配体的二芳基醚环番的构象受限产物的表征。该仪器还用于建立二芳基甲烷天然产物和类似物的库，可用于获得有关利什曼病的知识。此外，NMR光谱仪还用于表征水溶性单萜类化合物和植物树脂，用于对抗瓦螨病毒。最后，NMR光谱仪还用于表征具有潜在前药性质和潜在碳氢活化活性的合成钴（III）配位络合物。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Fort Lewis College is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer equipped with an automatic sample changer to support Professor Kenneth Miller and colleagues: William Collins, Callie Cole, Aimee Morris and Eric Miller (from San Juan Community College). This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically-relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the study of the structure of molecules. NMR spectroscopy is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the motions and interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution and the nearby San Juan Community College in New Mexico. The award of an NMR spectrometer is aimed at enhancing research and education at all levels. This instrument acquisition impacts the characterization of conformationally-constrained products of diarylether cyclophanes prepared to develop chiral ligands for asymmetric catalysis. The instrumentation is also used to establish a library of diarylmethane natural products and analogues that may be used to gain knowledge on Leishmaniasis. In addition, the NMR spectrometer is used in the characterization of water solubilized monoterpenoids and plant resins used against the varroa destructor virus. Finally, the NMR spectrometer is also used to characterize synthetic cobalt(III) coordination complexes having potential prodrug properties and potential carbon-hydrogen activation activity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.