NSF-DFG Confine: Building functional supraparticles through directed assembly of nonspherical nanoparticles under confinement

NSF-DFG Confine：通过在限制下定向组装非球形纳米粒子来构建功能性超粒子

• 批准号: 2223453
• 负责人: Xingchen Ye
• 金额: $ 38.21万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2223453&HistoricalAwards=false
• 关键词: NSF; DFG; Confine; Building; functional

Nanoparticles are finding use in almost all sectors of our economy from personal care to drug delivery. Their utility arises from the ability to access new properties that depend on their size, shape, and precise arrangement – called self-assembly. Self-assembly of nanoparticles in confined geometries hold the promise to build functional materials and devices with important properties that are otherwise not available. This award is a collaboration between Indiana University in the United States and Friedrich-Alexander-Universität Erlangen-Nürnberg in Germany to create well-defined supraparticles consisting of tens to thousands of nonspherical nanoparticles through directed self-assembly within liquid droplets and small channels. This award will expand the toolbox of supraparticle-by-design and will lay the groundwork for future computational studies of nanoparticle assembly by incorporating realistic interactions. Broader impacts of this project emphasize collaboration between experimentalists and computational scientists to enhance graduate and undergraduate education through multidisciplinary research. Summer research opportunities will be provided to students from underrepresented groups. Interactive modules to illustrate basic concepts of self-assembly will be designed and presented at local science museums and festivals. The overall objective of this award is to advance the design and synthesis of supraparticles by leveraging confined geometries to control nanoparticle assembly. Three aims will be undertaken. First, experimental, and computational approaches for the assembly of nonspherical nanoparticles into discrete supraparticles using emulsion droplets as templates will be established. Second, emulsion droplets generated using conventional emulsification methods and microfluidics to achieve precision synthesis of supraparticles composed of non-centrosymmetric nanoparticles will be leveraged. Third, one-dimensional supraparticles with emergent chiral optical properties via crystallization under cylindrical confinement will be fabricated. The interplay between experiment, establishing improved synthesis and characterization protocols, and theory, advancing coarse-grained modeling and simulation algorithms, will improve the fundamental understanding of self-assembly pathways in spherical and cylindrical confinement. The findings obtained and insights gained will also have applications in other systems that are affected by geometric constraints, such as crystallization of water in pores, virus capsid formation, biomineralization, macromolecular organization, and molecular packing in cells.This project was awarded through the “Chemistry and Transport in Confined Spaces (NSF-DFG Confine)" opportunity, a collaborative solicitation that involves the National Science Foundation and Deutsche Forschungsgemeinschaft (DFG).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

纳米颗粒正在发现从个人护理到药物提供的几乎所有经济领域的用途。它们的效用源于访问取决于其大小，形状和精确布置的新属性的能力 - 称为自组装。狭窄几何形状中纳米颗粒的自组装有望建立具有重要特性的功能材料和设备，而这些属性否则就不可用。该奖项是美国印第安纳大学与德国德国弗里德里希 - 亚历山大·纳弗尼特·恩伯格（Friedrich-Alexander-Universität）之间的合作，旨在通过液体液滴和小型频道中的定向自组件，创建由数千个非球纳米颗粒组成的定义明确的上皮。该奖项将扩大逐个设计的工具箱，并通过结合现实的相互作用来为纳米颗粒组件的未来计算研究奠定基础。该项目的更广泛的影响强调了实验者与计算科学家之间的合作，以通过多学科研究来增强研究生和本科教育。夏季研究机会将向来自代表性不足的团体的学生提供。互动模块以说明自组装基本概念的互动模块将在当地科学博物馆和节日中设计和介绍。该奖项的总体目的是通过利用限制几何形状来控制纳米颗粒组件来推进上颗粒的设计和合成。将实现三个目标。首先，将建立将非中心对称纳米颗粒组装到离散层上的实验和计算方法，将乳液液滴作为模板建立。其次，将利用使用常规乳化方法和微流体产生的乳液液滴来实现由非中粒对称纳米颗粒组成的上皮粒子的精确合成。第三，将在圆柱限制下通过结晶具有紧急手性光学特性的一维座位。实验之间的相互作用，建立改进的合成和表征方案以及理论，推进粗粒的建模和仿真算法，将改善对球形和圆柱限制中自组装途径的基本理解。获得的发现和获得的见解也将在受几何限制影响的其他系统中应用，例如毛孔中的水结晶，病毒capsid形成，生物矿化，大分子分子组织和分子包装在细胞中的分子包装，这些项目是通过“限制的机构”（NSFG-DFG DFG）授予的。以及德意志福尚斯格林（Deutsche Forschungsgemeinschaft）（DFG）。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，被视为通过评估而被视为珍贵的支持。

项目成果

Controlled Self-Assembly of Gold Nanotetrahedra into Quasicrystals and Complex Periodic Supracrystals

金纳米四面体受控自组装成准晶和复杂周期超晶

• DOI: 10.1021/jacs.3c05299
• 发表时间: 2023
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Wang, Yi;Chen, Jun;Li, Ruipeng;Götz, Alexander;Drobek, Dominik;Przybilla, Thomas;Hübner, Sabine;Pelz, Philipp;Yang, Lin;Apeleo Zubiri, Benjamin
• 通讯作者: Apeleo Zubiri, Benjamin